Gluconic acid derivatives for use in the treatment and/or prevention of microbial infections
Pharmaceutical compositions and methods of using said pharmaceutical compositions are provided herein. A method of preventing preterm birth in a pregnant individual is also provided, said method comprising administering to said individual a pharmaceutical composition comprising a compound of Formula XX or a lactone thereof of formula XIX or XXI and preventing said preterm birth by said administration.
1. A method for preventing preterm birth in a pregnant individual with bacterial vaginosis, said method consisting of administering to said individual a pharmaceutical composition comprising a compound of Formula XX,
or a lactone thereof of formula XIX or XXI,
and
preventing said preterm birth by said administration;
wherein said pharmaceutical composition comprises at least 5 wt % of the compound of Formula XX, XIX, XXI or combination thereof, and wherein said compound of Formula XX, XIX, XXI or combination thereof are the sole antimicrobial agent in said pharmaceutical composition.
2. The method according to claim 1 , wherein the compound is of Formula XIX or Formula XX.
3. The method according to claim 1 , wherein the compound is of Formula XIX.
4. The method according to claim 1 , wherein the pharmaceutical composition comprises the compound of Formula XIX and the compound of Formula XX.
5. The method according to claim 1 , wherein the pharmaceutical composition comprises no more than 10 wt % water.
6. The method according to claim 1 , wherein the pharmaceutical composition consists of the compound of Formula XIX alone or in combination with the compound of Formula XX or the compound of Formula XXI, or both, and one or more pharmaceutically acceptable excipients.
7. The method according to claim 1 , wherein the individual is a mammal.
8. The method according to claim 7 , wherein the mammal is a human.
9. The method of claim 1 , wherein said individual has an elevated risk for preterm birth.
10. The method according to claim 1 , wherein the pharmaceutical composition is administered vaginally.
11. The method according to claim 1 , wherein said pharmaceutical composition is formulated as a tampon, vagitorium, vaginal aerosol, vaginal cup, vaginal gel, vaginal insert, vaginal patch, vaginal ring, vaginal sponge, vaginal suppository, vaginal cream, vaginal emulsion, vaginal foam, vaginal lotion, vaginal ointment, vaginal powder, vaginal shampoo, vaginal solution, vaginal spray, vaginal suspension, vaginal tablet, vaginal rod, vaginal disc, vaginal device, and any combination thereof, or wherein the pharmaceutical composition is present on a sanitary napkin, an incontinence pad or diaper, or a panty liner.
12. The method according to claim 1 , wherein said compound is administered as an oligomer or polymer.
13. The method according to claim 12 , wherein the oligomer or polymer comprises one or more compounds selected from the group consisting of gluconic acid and δ-gluconolactone.