Membrane-based purge gas and sample transfer for laser ablation sample processing
Systems and methods are described for transferring gas from an ablation cell to an inductively coupled plasma analysis system via a gas exchange membrane transfer line to exchange gas introduced to the ablation cell with a sweep gas. A system embodiment includes, but is not limited to, a laser ablation cell configured to generate a sample transfer stream through laser ablation of a sample and introduction of a carrier gas to flow the ablated sample from the laser ablation cell; an inductively-coupled plasma analysis device configured to measure one or more analytes in the sample transfer stream; and a gas exchange membrane transfer line fluidically coupled between the laser ablation cell and the inductively-coupled plasma analysis device, the gas exchange membrane transfer line configured to replace gas in the sample transfer stream with sweep gas via gas exchange across a membrane of the gas exchange membrane transfer line.
1. A system for controlling flow of gas from a laser ablation cell, comprising:
a laser ablation cell configured to generate a sample transfer stream through laser ablation of a sample and introduction of a carrier gas to flow the ablated sample from the laser ablation cell;
an inductively-coupled plasma analysis device configured to measure one or more analytes in the sample transfer stream; and
a gas exchange membrane transfer line fluidically coupled between the laser ablation cell and the inductively-coupled plasma analysis device, the gas exchange membrane transfer line configured to replace gas in the sample transfer stream with sweep gas via gas exchange across a membrane of the gas exchange membrane transfer line, wherein the gas exchange membrane transfer line has a length of at least six feet to replace substantially all the gas in the sample transfer stream with sweep gas prior to receipt by the inductively-coupled plasma analysis device.
2. The system of claim 1 , further comprising:
a mass flow controller fluidically coupled with a source of the sweep gas, the mass flow controller configured to introduce the sweep gas to an inlet of the gas exchange membrane transfer line at a controlled flow rate.
3. The system of claim 1 , wherein the gas exchange membrane transfer line includes an inner tube surrounded by an outer tube, wherein at least a portion of the inner tube includes the gas exchange membrane.
4. The system of claim 3 , wherein the outer tube defines an inlet configured to receive the sweep gas into a region defined between the inner tube and the outer tube.
5. The system of claim 4 , wherein the region defined between the inner tube and the outer tube is an annular region.
6. The system of claim 4 , wherein the inlet is positioned adjacent an end of the gas exchange membrane transfer line coupled with the inductively-coupled plasma analysis device such that the sweep gas and the sample transfer stream at least partially flow through the gas exchange membrane transfer line in an opposite flow path arrangement.
7. The system of claim 1 , further comprising a sample carousel configured to hold a plurality of samples for serial introduction to the laser ablation cell for generation of an individual sample transfer stream from each respective sample.
8. A method for controlling flow of gas from a laser ablation cell, comprising:
transferring a sample transfer stream containing a plurality of sample particles and at least one gas from a laser ablation system to a gas exchange membrane transfer line having a length of at least six feet;
introducing a sweep gas to the gas exchange membrane transfer line;
separating substantially all of the at least one gas from the plurality of sample particles via exchange with at least a portion of the sweep gas within the gas exchange membrane transfer line; and
transferring the sample transfer stream through the gas exchange membrane transfer line to an inductively-coupled plasma analysis device.
9. The method of claim 8 , wherein introducing a sweep gas to the gas exchange membrane transfer line includes introducing the sweep gas, via a mass flow controller, to the gas exchange membrane transfer line at a controlled flow rate.
10. The method of claim 8 , wherein the gas exchange membrane transfer line includes an inner tube surrounded by an outer tube, wherein at least a portion of the inner tube includes a membrane permeable by the sweep gas and the at least one gas, the membrane substantially impermeable to the plurality of sample particles.
11. The method of claim 10 , wherein introducing a sweep gas to the gas exchange membrane transfer line includes introducing the sweep gas to a region between the inner tube and the outer tube, and wherein transferring a sample transfer stream containing a plurality of sample particles and at least one gas from a laser ablation system to a gas exchange membrane transfer line includes transferring the sample transfer stream through the inner tube.
12. The method of claim 11 , wherein at least a portion of the sweep gas and the sample transfer stream flow travel in opposite directions through the gas exchange membrane transfer line.
13. The method of claim 8 , wherein separating at least a portion of the at least one gas from the plurality of sample particles via exchange with at least a portion of the sweep gas includes separating at least 99 % of the at least one gas from the plurality of sample particles via exchange with at least a portion of the sweep gas.
14. A system for controlling flow of gas from a laser ablation system, comprising:
a laser ablation system configured to generate a sample transfer stream through laser ablation of a sample and introduction of a carrier gas to flow the ablated sample from the laser ablation system;
an inductively-coupled plasma analysis device configured to measure one or more analytes in the sample transfer stream; and
a gas exchange membrane transfer line fluidically coupled between the laser ablation system and the inductively-coupled plasma analysis device, the gas exchange membrane transfer line configured to replace gas in the sample transfer stream with sweep gas via gas exchange across a membrane of the gas exchange membrane transfer line, wherein the gas exchange membrane transfer line has a length of at least six feet to replace substantially all the gas in the sample transfer stream with sweep gas prior to receipt by the inductively-coupled plasma analysis device.
15. The system of claim 14 , further comprising:
a mass flow controller fluidically coupled with a source of the sweep gas, the mass flow controller configured to introduce the sweep gas to an inlet of the gas exchange membrane transfer line at a controlled flow rate.
16. The system of claim 14 , wherein the gas exchange membrane transfer line includes an inner tube surrounded by an outer tube, wherein at least a portion of the inner tube includes the gas exchange membrane.
17. The system of claim 16 , wherein the inner outer tube defines an inlet configured to receive the sweep gas into a region defined between the inner tube and the outer tube.
18. The system of claim 17 , wherein the region defined between the inner tube and the outer tube is an annular region.
19. The system of claim 18 , wherein the inlet is positioned adjacent an end of the gas exchange membrane transfer line coupled with the inductively-coupled plasma analysis device such that the sweep gas and the sample transfer stream at least partially flow through the gas exchange membrane transfer line in an opposite flow path arrangement.
20. The system of claim 14 , further comprising a sample carousel configured to hold a plurality of samples for serial introduction to the laser ablation system for generation of an individual sample transfer stream from each respective sample.