Granted Patent B2

US 12,383,336 · App. 18/194,788 · Granted Aug 12, 2025

Inventors: Clara Jaquet (Paris, FR); Michiel Schaap (Oegstgeest, NL); Ying Bai (Belmont, CA); Leo J. Grady (Darien, CT); Charles A. Taylor (Atherton, CA)

Assignee: Heartflow, Inc.

A61B34/10A61B34/25G06F3/048G16H50/50A61B2034/105

Abstract

Claims (51)

1. A computer-implemented method for displaying information of a functional relationship between a vasculature and a perfused tissue, the method comprising:

receiving a current patient-specific physiological state and a current patient-specific vascular model of a patient's anatomy while in the current patient-specific physiological state, the current patient-specific physiological state being one of an exercise state, a resting state, or a hyperemic state;

generating a user interface comprising a display of the current patient-specific vascular model;

receiving, via the user interface, a selection indicating a changed patient-specific physiological state, the changed patient-specific physiological state being one of an exercise state, a resting state, or a hyperemic state different from the current patient-specific physiological state;

upon receiving the selection, generating an updated patient-specific vascular model based on the changed patient-specific physiological state;

displaying, in the user interface, the updated patient-specific vascular model;

receiving a patient-specific tissue model including patient tissue; and

determining a blood supply estimate distribution in the current patient-specific vascular model based on the current patient-specific physiological state and the received patient-specific tissue model.

2. The computer-implemented method of claim 1 , further comprising:

receiving at least one boundary condition of the current patient-specific vascular model,

wherein the blood supply estimate distribution is further determined based on the at least one boundary condition.

3. The computer-implemented method of claim 1 , wherein the displaying displays the blood supply estimate distribution.

4. The computer-implemented method of claim 1 , further comprising:

receiving at least one boundary condition of the current patient-specific vascular model,

wherein the at least one boundary condition defines a boundary of the current patient-specific vascular model.

5. The computer-implemented method of claim 1 , wherein upon receiving the selection further includes updating the patient-specific tissue model, and the displaying further includes displaying in the user interface an updated version of the patient-specific tissue model based on the changed patient-specific physiological state.

6. The computer-implemented method of claim 1 , further comprising:

determining a blood supply estimate distribution in the current patient-specific vascular model based on the current patient-specific physiological state; and

updating at least one boundary condition of the current patient-specific vascular model based on the blood supply estimate distribution.

7. A system for displaying information of a functional relationship between a vasculature and a perfused tissue, the system comprising:

at least one data storage device storing instructions for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue; and

at least one processor configured to execute the instructions to perform operations including:

receiving a current patient-specific physiological state and a current patient-specific vascular model of a patient's anatomy while in the current patient-specific physiological state, the current patient-specific physiological state being one of an exercise state, a resting state, or a hyperemic state;

generating a user interface comprising a display of the current patient-specific vascular model;

receiving, via the user interface, a selection indicating a changed patient-specific physiological state, the changed patient-specific physiological state being one of an exercise state, a resting state, or a hyperemic state different from the current patient-specific physiological state;

upon receiving the selection, generating an updated patient-specific vascular model based on the changed patient-specific physiological state;

displaying, in the user interface, the updated patient-specific vascular model;

receiving a patient-specific tissue model including patient tissue; and

determining a blood supply estimate distribution in the current patient-specific vascular model based on the current patient-specific physiological state and the received patient-specific tissue model.

8. The system of claim 7 , the operations further comprising:

receiving at least one boundary condition of the current patient-specific vascular model,

wherein the blood supply estimate distribution is further determined based on the at least one boundary condition.

9. The system of claim 7 , wherein the displaying displays the blood supply estimate distribution.

10. The system of claim 7 , the operations further comprising:

receiving at least one boundary condition of the current patient-specific vascular model,

wherein the at least one boundary condition defines a boundary of the current patient-specific vascular model.

11. A non-transitory computer-readable medium storing operations for displaying information of a functional relationship between a vasculature and a perfused tissue, the operations comprising:

receiving a current patient-specific physiological state and a current patient-specific vascular model of a patient's anatomy while in the current patient-specific physiological state, the current patient-specific physiological state being one of an exercise state, a resting state, or a hyperemic state;

generating a user interface comprising a display of the current patient-specific vascular model;

receiving, via the user interface, a selection indicating a changed patient-specific physiological state, the changed patient-specific physiological state being one of an exercise state, a resting state, or a hyperemic state different from the current patient-specific physiological state;

upon receiving the selection, generating an updated patient-specific vascular model based on the changed patient-specific physiological state;

displaying, in the user interface, the updated patient-specific vascular model;

receiving a patient-specific tissue model including patient tissue; and

determining a blood supply estimate distribution in the current patient-specific vascular model based on the current patient-specific physiological state and the received patient-specific tissue model.

12. The non-transitory computer-readable medium of claim 11 , the operations further comprising:

receiving at least one boundary condition of the current patient-specific vascular model,

wherein the blood supply estimate distribution is further determined based on the at least one boundary condition.

13. The non-transitory computer-readable medium of claim 11 , wherein the displaying displays the blood supply estimate distribution.

14. The non-transitory computer-readable medium of claim 11 , the operations further comprising:

receiving at least one boundary condition of the current patient-specific vascular model,

wherein the at least one boundary condition defines a boundary of the current patient-specific vascular model.

Assignments (3)

Continuity (5)

References Cited (49)

Cited By (7)

US 12,440,180 US 12,499,539 US 12,555,228 US 12,558,048 US 12,599,352 US 12,635,965 US 12,714,382