Medical device with tunable hydrophobicity and method of manufacture
A medical device include a polyurethane layer and a hydro-specific layer that is covalently bonded to the polyurethane layer. The polyurethane layer may include a plurality of monomer residues, at least some of which include pendent alkene groups. The hydro-specific layer may be a hydrophilic layer or a hydrophobic layer depending on the specific molecules used to form the hydro-specific layer. As an example, the hydro-specific layer may be covalently bonded to the polyurethane layer via a thiol-ene or alkene hydrothiolation reaction between the plurality of pendent alkene groups and a plurality of thiol-terminated hydro-specific molecules forming the hydro-specific layer.
1 . A medical device, comprising:
a polyurethane layer comprising a plurality of monomer residues;
wherein at least some of the plurality of monomer residues include a chain extender molecule with a pendent alkene group;
wherein the chain extender molecule comprises a residue of one or more of:
a hydro-specific layer covalently bonded to the polyurethane layer via a thiol-ene reaction between the plurality of pendent alkene groups and a plurality of thiol-terminated hydro-specific molecules forming the hydro-specific layer.
2 . The medical device of claim 1 , wherein the hydro-specific layer comprises a hydrophilic layer.
3 . The medical device of claim 2 , wherein the hydrophilic layer is formed from a plurality of thiol-terminated hydro-specific molecules comprising one or more of:
4 . The medical device of claim 1 , wherein the hydro-specific layer comprises a hydrophobic layer.
5 . The medical device of claim 4 , wherein the hydrophobic layer is formed from a plurality of thiol-terminated hydro-specific molecules comprising one or more of:
6 . The medical device of claim 1 , comprising a first region and a second region, with the polyurethane layer extending through the first region and the second region, and the hydro-specific layer comprises a first hydro-specific layer within the first region covalently bonded to the polyurethane layer and a second hydro-specific layer, different from the first hydro-specific layer, disposed within the second region covalently bonded to the polyurethane layer.
7 . The medical device of claim 6 , wherein the first hydro-specific layer comprises a hydrophilic layer and the second hydro-specific layer comprises a hydrophobic layer.
8 . A medical device having a first region and a second region, the medical device comprising:
a polyurethane layer comprising a plurality of monomer residues, the polyurethane layer extending through the first region and the second region;
wherein at least some of the plurality of monomer residues include a chain extender molecule with a pendent alkene group;
wherein the chain extender molecule comprises a residue of one or more of:
a first hydro-specific layer covalently bonded to the polyurethane layer within the first region; and
a second hydro-specific layer covalently bonded to the polyurethane layer within the second region.
9 . The medical device of claim 8 , wherein the first hydro-specific layer provides a first contact angle and the second hydro-specific contact angle provides a second contact angle different from the first contact angle.
10 . The medical device of claim 9 , wherein the first hydro-specific layer provides a contact angle of less than or equal to 90 degrees.
11 . The medical device of claim 9 , wherein the second hydro-specific layer provides a contact angle of greater than 90 degrees.
12 . The medical device of claim 8 , wherein the first hydro-specific layer is covalently bonded to the polyurethane layer via a thiol-ene reaction between the plurality of pendent alkene groups and a plurality of thiol-terminated hydro-specific molecules forming the first hydro-specific layer.
13 . The medical device of claim 8 , wherein the second hydro-specific layer is covalently bonded to the polyurethane layer via a thiol-ene reaction between the plurality of pendent alkene groups and a plurality of thiol-terminated hydro-specific molecules forming the second hydro-specific layer.
14 . A medical device, comprising:
a polyurethane layer formed to include a plurality of pendent functional chemical handles;
wherein the polyurethane layer include a chain extender molecule having the plurality of pendent functional chemical handles;
wherein the chain extender molecule comprises a residue of one or more of:
a hydro-specific layer covalently bonded to the polyurethane layer, the hydro-specific layer including a plurality of hydro-specific molecules covalently bonded to the plurality of pendent functional chemical handles.
15 . The medical device of claim 14 , wherein the plurality of pendent functional chemical handles comprise a plurality of pendant alkene groups.
16 . The medical device of claim 15 , wherein the plurality of hydro-specific molecules comprise thiol-terminated hydro-specific molecules.
17 . The medical device of claim 16 , wherein the hydro-specific layer is covalently bonded to the polyurethane layer via an alkene hydrothiolation reaction between the plurality of pendant alkene groups and the thiol-terminated hydro-specific molecules.