IP Library › Granted Patent US 12,350,443
Granted Patent B2
US 12,350,443 · App. 18/236,195 · Granted Jul 8, 2025

Enhanced flexibility neurovascular catheter

Inventors: Brandon Yee (Oakland, CA); Ashoor Shahbazi Yourgenlow (San Jose, CA); Yi Yang (San Francisco, CA); Farhad Khosravi (Los Altos Hills, CA); Joseph Rimsa (Palo Alto, CA)
Assignee: Incept, LLC
A61M25/0012A61M25/0013A61B17/22031A61B2217/005A61M25/0147A61M2205/0266
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Quick Facts
Patent No.
US 12,350,443
App. No.
18/236,195
Filed
Aug 21, 2023
Granted
Jul 8, 2025
Kind
B2
Art Unit
3726
USPC
264/129
Abstract

A catheter is provided comprising localized regions of modified flexibility. The regions of modified flexibility may comprise a softened inner liner, for example softened via stretching the inner liner or disposing a plurality of holes in the inner liner, to modify the bending stiffness and/or tensile stiffness of the catheter. The catheter may further include an axially extending filament that at least partially overlaps the softened portion of the inner liner. The axially extending filament may include an anchoring section to anchor the at least one axially extending filament in a section of the catheter that includes the helical coil.

Claims (20)

1. A method of making a flexible distal zone on a neurovascular catheter, having an elongate tubular body with a distal end, comprising:

forming a tubular inner liner on a mandrel;

softening at least a portion of the tubular inner liner on the mandrel, wherein softening comprises applying tension axially to the portion of the tubular inner liner such that the tubular inner liner comprises a stretched portion and an unstretched portion after softening the portion of the tubular inner liner;

applying a helical coil to an outside of the tubular inner liner;

positioning a plurality of tubular segments over the helical coil, the plurality of tubular segments having durometers that decrease in a distal direction;

heating the plurality of tubular segments to form the flexible distal zone on the neurovascular catheter; and

removing the mandrel.

2. The method of claim 1 , wherein the softened portion of the tubular inner liner comprises a distal 15 mm to 20 mm of the tubular inner liner.

3. The method of claim 1 , further comprising achieving a thickness of the softened portion of the tubular inner liner of 0.00025 inches to 0.00075 inches.

4. The method of claim 1 , further comprising aligning one or more polymer chains of the stretched portion of the tubular inner liner relative to one another in a similar or substantially similar direction as the applied tension.

5. The method of claim 1 , further comprising coating the tubular inner liner with a tie layer.

6. The method of claim 5 , wherein the tie layer has a wall thickness of no more than 0.005 inches.

7. The method of claim 5 , wherein the tie layer extends along at least a most distal 20 cm of the neurovascular catheter.

8. The method of claim 5 , further comprising positioning at least one axially extending tensile strength enhancing filament over the tie layer.

9. The method of claim 8 , further comprising overlapping the softened portion of the tubular inner liner with the at least one axially extending tensile strength enhancing filament.

10. The method of claim 8 , wherein the at least one axially extending tensile strength enhancing filament extends along at least a most distal 15 cm of a length of the neurovascular catheter.

11. The method of claim 8 , wherein the at least one axially extending tensile strength enhancing filament comprises multiple fibers.

12. The method of claim 1 , wherein the stretched portion is on a distal portion of the tubular inner liner.

13. The method of claim 1 , wherein softening the portion of the tubular inner liner comprises stretching the portion of the tubular inner liner 100% to 150% of a pre-stretch length.

14. The method of claim 1 , wherein positioning the plurality of tubular segments over the helical coil comprises positioning at least seven tubular segments over the helical coil.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2023
From: YEE, BRANDON; YOURGENLOW, ASHOOR SHAHBAZI; YANG, YI; KHOSRAVI, FARHAD; RIMSA, JOSEPH
To: IMPERATIVE CARE, INC.
Reel/Frame 064668/0306 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2023
From: IMPERATIVE CARE, INC.
To: INCEPT, LLC
Reel/Frame 064668/0337 →
Continuity (3)
Continuation 16833585 · Mar 28, 2020
Provisional Application 62826203 · Mar 29, 2019
Related Publication 20240082536A1 · Mar 14, 2024
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