IP Library › Granted Patent US 12,251,473
Granted Patent B2
US 12,251,473 · App. 18/243,299 · Granted Mar 18, 2025

Non-surfactant type oil-water dispersion composition, non-surfactant type water-oil dispersion composition, and manufacturing methods for both compositions

Inventor: Chul Hwan Kim (Daejeon, KR)
Assignees: SCAI THERAPEUTICS CO., LTD.; Chul Hwan Kim
A61K9/1611A61K8/04A61K9/10A61K31/196A61K31/337A61K31/352A61K31/37A61K31/415A61K31/496A61K31/5415A61K31/704A61K31/7068A61K38/13
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,251,473
App. No.
18/243,299
Granted
Mar 18, 2025
Kind
B2
Abstract

A non-surfactant type oil-water (O/W) dispersion composition containing non-polar solvent droplets in a polar solvent, of which transparency is 90-100%, and a non-surfactant type water-oil (W/O) dispersion composition containing polar solvent droplets in a non-polar solvent, of which transparency is 90-100% are disclosed. Also disclosed are methods for manufacturing methods for both of the compositions.

Claims (10)

1. A water-oil (W/O) dispersion composition consisting of polar solvent droplets and a non-polar solvent in which the polar solvent droplets are dispersed,

wherein a transparency of the water-oil (W/O) dispersion composition is 90 to 100%,

wherein the water-oil (W/O) dispersion composition does not comprise a surfactant,

wherein the water-oil (W/O) dispersion composition does not comprise silica,

wherein an average particle diameter of the polar solvent droplets is 20 nm or less,

wherein the polar solvent droplets optionally comprise an active ingredient,

wherein the polar solvent droplets are contained in an amount of 0.01 wt. % (W/W) to 30.0 wt. % (W/W) based on a total weight of the water-oil (W/O) dispersion composition,

wherein polar solvent of the polar solvent droplets is water, and

wherein the non-polar solvent is an oil, hexane, or a mixture thereof.

2. The water-oil (W/O) dispersion composition according to claim 1 , wherein the active ingredient is one or more selected from the group consisting of adenosine, arbutin, vitamin C, vitamin B3, vitamin B5, vitamin H, acetylglucosamine, peptide, and derivatives thereof.

Assignments (2)
MERGER Recorded Jan 22, 2025
From: ASTIN CO., LTD.
To: SCAI THERAPEUTICS CO., LTD.
Reel/Frame 069969/0622 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 7, 2023
From: KIM, CHUL HWAN
To: ASTIN CO., LTD.; KIM, CHUL HWAN
Reel/Frame 066001/0277 →
Priority Claims (1)
KR 10-2018-0044547 · Apr 17, 2018 · national
Continuity (2)
Division 17046242
Related Publication 20230414513A1 · Dec 28, 2023
References Cited (74)
US 5968549A · New et al. · 1999 [cited by applicant]
US 6709662B1 · Gers-Barlag · 2004 [cited by examiner]
US 8181941B2 · Von Wimmersperg · 2012 [cited by applicant]
US 8470873B2 · Chen · 2013 [cited by applicant]
US 20070207173A1 · Chen · 2007 [cited by applicant]
US 20080262103A1 · Stork et al. · 2008 [cited by applicant]
US 20100016200A1 · Nagare et al. · 2010 [cited by applicant]
US 20100136207A1 · Kim et al. · 2010 [cited by applicant]
US 20150196481A1 · Mitra et al. · 2015 [cited by applicant]
US 20150231070A1 · Huang · 2015 [cited by applicant]
US 20160199269A1 · Lee · 2016 [cited by applicant]
US 20160271023A1 · Bekemeier et al. · 2016 [cited by applicant]
US 20170112764A1 · Wu · 2017 [cited by applicant]
US 20170319458A1 · Matsufuji et al. · 2017 [cited by applicant]
US 20170360661A1 · Cassin et al. · 2017 [cited by applicant]
JP 10510256A · 1998 [cited by applicant]
JP 2000095635A · 2000 [cited by applicant]
JP 2006281038A · 2006 [cited by applicant]
JP 2009525342A · 2009 [cited by applicant]
JP 2015124168A · 2015 [cited by applicant]
JP 2018501242A · 2018 [cited by applicant]
KR 1020040035320A · 2004 [cited by applicant]
KR 100452165B1 · 2004 [cited by applicant]
KR 100482355B1 · 2005 [cited by applicant]
KR 1020050078683A · 2005 [cited by applicant]
KR 1020060004918A · 2006 [cited by applicant]
KR 100823345B1 · 2008 [cited by applicant]
KR 100836035B1 · 2008 [cited by applicant]
KR 1020080091286A · 2008 [cited by applicant]
KR 100878026B1 · 2009 [cited by applicant]
KR 1020090051745A · 2009 [cited by applicant]
KR 100951706B1 · 2010 [cited by applicant]
KR 1020100092594A · 2010 [cited by applicant]
KR 100991675B1 · 2010 [cited by applicant]
KR 101002433B1 · 2010 [cited by applicant]
KR 101015384B1 · 2011 [cited by applicant]
KR 101038589B1 · 2011 [cited by applicant]
KR 101043355B1 · 2011 [cited by applicant]
KR 1020120042396A · 2012 [cited by applicant]
KR 101157144B1 · 2012 [cited by applicant]
KR 101192161B1 · 2012 [cited by applicant]
KR 101199966B1 · 2012 [cited by applicant]
KR 1020130025988A · 2013 [cited by applicant]
KR 101259452B1 · 2013 [cited by applicant]
KR 101270300B1 · 2013 [cited by applicant]
KR 101315440B1 · 2013 [cited by applicant]
KR 101199580B1 · 2013 [cited by applicant]
KR 101332064B1 · 2013 [cited by applicant]
KR 101399706B1 · 2014 [cited by applicant]
KR 101472304B1 · 2014 [cited by applicant]
KR 101529480B1 · 2015 [cited by applicant]
KR 1020150086284A · 2015 [cited by applicant]
KR 1020160095089A · 2016 [cited by applicant]
KR 1020160101913A · 2016 [cited by applicant]
KR 101654576B1 · 2016 [cited by applicant]
KR 101659653B1 · 2016 [cited by applicant]
KR 101674014B1 · 2016 [cited by applicant]
KR 1020160146669A · 2016 [cited by applicant]
KR 1020170002989A · 2017 [cited by applicant]
KR 1020170048190A · 2017 [cited by applicant]
KR 1020170094345A · 2017 [cited by applicant]
KR 1020170097709A · 2017 [cited by applicant]
KR 1020190121055A · 2019 [cited by applicant]
WO WO2015099198A1 · 2015 [cited by examiner]
Younjin Min et al., “The role of interparticle and external forces in nanoparticle assembly”, Macmillan Publishers Limited, vol. 7, pp. 527-538, Jul. 2008. [cited by applicant]
Hai Ming Lu et al., “Size-Dependent Surface Tension and Tolman's Length of Droplets”, Langmuir 2005, 21, pp. 779-781. [cited by applicant]
Øivind Wilhelmsen et al., “Communication: Tolman length and rigidity constants of water and their role in nucleation”, The Journal of Chemical Physics, vol. 142, pp. 171103-1-171103-5, 2015. [cited by applicant]
Mohammad Hassan Shahavi et al., “Evaluation of critical parameters for preparation of stable clove oil nanoemulsion”, Arabian Journal of Chemistry, 2015, pp. 1-6. [cited by applicant]
Yeon-Ji Jo et al., “Preparation of Nanoemulsions Containing Curcumin by High Pressure Homogenization”, vol. 18, No. 4. pp. 341-347, 2014. [cited by applicant]
In-Sang Yoo “Formation and Stability of Nanoemulsion Containing CoQ10 by Mechanical Emulsification”, Appl. Chem. Eng., vol. 23, No. 5, Oct. 2012, pp. 467-473. [cited by applicant]
Myoung Sun Lim et al., “Preparation of Nano-emulsion Containing Polygonum aviculare Extract for Enhanced Transdermal Delivery”, Appl. Chem. Eng., vol. 23, No. 2, Apr. 2012, pp. 222-227. [cited by applicant]
International Search Report issued Jul. 19, 2019 in International Application No. PCT/KR2019/004593. [cited by applicant]
Susanne Sihler et al., “Highly Transparent w/o Pickering Emulsions without Adjusting the Refractive Index of the Stabilizing Particles”, Langmuir, 2017, vol. 33, No. 39, pp. 10302-10310 (9 pages total). [cited by applicant]
Koji Nakabayashi et al., “Highly clear and transparent nanoemulsion preparation under surfactant-free conditions using tandem acoustic emulsification”, ChemComm, 2011, vol. 47, No. 20, pp. 5765-5767 (3 pages total). [cited by applicant]