Method for preparing nanoemulsion
Provided is a method for preparing a nanoemulsion, including mixing an oil phase part (A) containing a ceramide or derivative thereof, cholesterol, non-ionic surfactant, phospholipid and a polyol, a perfume part (B) containing a perfume ingredient, non-ionic surfactant and an alcohol, and an aqueous phase part (C) containing the other water-soluble active ingredients. When a nanoemulsion is obtained by the method, it is possible to reduce processing time and cost since a non-ionic surfactant is used without a high-pressure emulsification process, and the obtained nanoemulsion is more stable against a change in temperature than the other solubilized formulations.
1. A method for preparing a nanoemulsion, comprising the steps of:
a) mixing, warming and dissolving a ceramide or derivative thereof, cholesterol, first non-ionic surfactant, and a polyol to obtain an oil phase part (A);
b) dissolving a perfume ingredient and second non-ionic surfactant into an alcohol to obtain a perfume part (B);
c) dispersing or dissolving a polyol and water-soluble active ingredient into water to obtain an aqueous phase part (C);
d) adding the oil phase part (A) to the aqueous phase part (C) and further adding the perfume part (B) to the aqueous phase part (C), followed by agitation, to obtain a reaction mixture; and
e) filtering the reaction mixture of step d) through a filtering paper or a filtering cloth,
wherein the first non-ionic surfactant or the second non-ionic surfactant is a mixture of phospholipid with hydrogenated castor oil, octyldodeceth, or Choleth.
2. The method for preparing a nanoemulsion according to claim 1 , wherein the polyol used in step a) and the polyol used in step c) is at least one selected from the group consisting of propylene glycol, dipropylene glycol, 1,3-butylene glycol, pentylene glycol, and 1,2-hexanediol.
3. The method for preparing a nanoemulsion according to claim 1 , wherein the first non-ionic surfactant is identical to the second non-ionic surfactant.
4. The method for preparing a nanoemulsion according to claim 1 , wherein the perfume ingredient is oil used as perfume, perfume or a combination mixture thereof.