Granted Patent B2

US 12,202,800 · App. 18/243,409 · Granted Jan 21, 2025

Inventors: Masato Murai (Tokyo, JP); Jun Takehara (Tokyo, JP); Daiki Okado (Tokyo, JP)

Assignee: API CORPORATION

C07D211/60

Abstract

Claims (24)

1. A method for producing a compound represented by the formula (1):

wherein LG is a leaving group, PG 1 is an amino-protecting group, and R is a hydrocarbon group having 1-8 carbon atoms and optionally having substituent(s),

comprising

reacting a compound represented by the formula (6):

with an amino group protecting agent to obtain a compound represented by the formula (7):

wherein each symbol is as defined above, or a salt thereof;

reacting the aforementioned compound represented by the formula (7) with a lactonization agent to obtain a compound represented by the formula (8):

wherein each symbol is as defined above;

reacting the aforementioned compound represented by the formula (8) with an esterification agent to obtain a compound represented by the formula (9):

wherein each symbol is as defined above; and

reacting the aforementioned compound represented by the formula (9) with a leaving group introduction agent.

2. A method for producing a compound represented by the formula (1):

wherein LG is a leaving group, PG 1 is an amino-protecting group, and R is a hydrocarbon group having 1-8 carbon atoms and optionally having substituent(s),

comprising

reacting a compound represented by the formula (8):

wherein PG 1 is as defined above,

with an esterification agent to give a compound represented by the formula (9):

wherein each symbol is as defined above; and

reacting the aforementioned compound represented by the formula (9) with a leaving group introduction agent.

3. A compound represented by the following formula (1a) or (1b):

wherein

Boc is a tert-butoxycarbonyl group,

Ac is an acetyl group, and

Ns is a p-nitrobenzenesulfonyl group.

Assignments (2)

Priority Claims (1)

Continuity (2)

References Cited (48)