IP Library Granted Patent US 9,181,250
Granted Patent B2
US 9,181,250 · App. 14/404,288 · Granted Nov 10, 2015

Beta-lactamase inhibitor and process for preparing the same

Inventors: Takao Abe (Kanagawa, JP); Takeshi Furuuchi (Kanagawa, JP); Yoshiaki Sakamaki (Kanagawa, JP)
Assignee: MEIJI SEIKA PHARMA CO., LTD.
C07D471/08A61K31/43A61K31/437A61K31/439A61K31/444A61K31/4545A61K31/5377A61K31/545A61K31/546A61K45/06C07D211/60
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Quick Facts
Patent No.
US 9,181,250
App. No.
14/404,288
Granted
Nov 10, 2015
Kind
B2
Abstract

A diazabicyclooctane compound, which is a beta-lactame inhibitor, represented by the following formula (I): wherein A represents Ra(Rb)N— or RcO—; B represents NH or NC 1-6 alkyl; C represents benzyl, H or SO 3 M, wherein M represents H, an inorganic or an organic cation; Ra and Rb represent H, C 1-6 alkyl or acyl; Rc represents C 1-6 alkyl or a heterocyclyl; A is unsubstituted or substituted with 0 to 4 substituents Fn1, wherein Fn1 represents C 1-6 alkyl, O═, or Rg-(CH 2 ) 0-3 —, wherein Rg represents a heterocyclyl, phenyl, heteroaryl, acyl, RdO 2 S—, Re(Rf)N—, Re(Rf)NCO—, ReO—, ReOCO— or a protective group, wherein Rd represents C 1-6 alkyl or MO—; Re and Rf represent H or C 1-6 alkyl, and a heterocycle having at least one nitrogen atom may be formed between Ra and Rb, between Rc and B, or between Re and Rf.

Claims (1)

1. A process for preparing (2S,5R)-methyl 5-(benzyloxyamino)piperidine-2-carboxylate or a hydrochloride thereof, comprising methyl esterifying (2S,5S)-5-hydroxypiperidine-2-carboxylic acid or a hydrochloride thereof, trifluoroacetylizing, benzyloxyaminating the hydroxyl group at the 5-position, and removing the trifluoroacetyl.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 18, 2015
From: ABE, TAKAO; FURUUCHI, TAKESHI; SAKAMAKI, YOSHIAKI; INAMURA, SEIICHI; MORINAKA, AKIHIRO
To: MEIJI SEIKA PHARMA CO., LTD.
Reel/Frame 035036/0331 →
Priority Claims (1)
JP 2012-122603 · May 30, 2012 · national
Continuity (1)
Related Publication 20150141401A1 · May 21, 2015