IP Library › Granted Patent US 12,551,421
Granted Patent B2
US 12,551,421 · App. 18/257,865 · Granted Feb 17, 2026

N-heptyl-glyceryl ether and synergistically active preservatives

Inventors: Kathrin Daniela Brandt (Duesseldorf, DE); Jan Jänichen (Hamburg, DE); Michael Kinder (Neuenkirchen, DE); Alexander Thiemann (Hasloh, DE); Ellen Schmitt (Hamburg, DE); Jessica Scholze (Stelle, DE); Sabine Steinmetzer (Wiesbaden, DE)
Assignee: Evonik Operations GmbH
A61K8/33A61K8/0291A61K8/34A61K8/345A61K8/36A61K8/365A61K8/368A61K8/498A61K8/678A61Q15/00A61K2800/524
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,551,421
App. No.
18/257,865
Granted
Feb 17, 2026
Kind
B2
Abstract

A composition contains n-heptyl-glyceryl ether and at least one further carefully chosen and synergistically active preservative.

Claims (39)

1 . A composition, comprising:

A) n-heptyl-glyceryl ether, and

B) at least one selected from the group consisting of

p-anisic acid, benzoic acid, sorbic acid, lactic acid, and salts of any of the before mentioned acids,

and phenylpropanol,

and

wherein the composition has a pH in the range of 4.0 to 8.5.

2 . The composition according to claim 1 , wherein component A) and component B) are comprised in a weight ratio of from 99:1 to 1:99.

3 . The composition according to claim 1 , wherein component A) is comprised in an amount of from of from 0.005 wt.-% to 99.0 wt.-%, wherein the weight percentages refer to a total composition.

4 . The composition according to claim 1 , wherein component B) is comprised in an amount of from 0.005 wt.-% to 99.0 wt.-%, wherein the weight percentages refer to a total composition.

5 . The composition according to claim 1 , wherein the composition comprises

C) at least one selected from the group consisting of deodorant and antiperspirant active ingredients.

6 . The composition according to claim 1 , wherein the composition comprises

D) at least one antioxidant.

7 . A formulation, comprising the composition according to claim 1 , wherein the formulation is selected from the group consisting of cleaning formulations, defoamers, coating formulations, and cosmetic formulations.

8 . The formulation according to claim 7 , wherein

component A) is comprised in an amount of from of from 0.005 wt.-% to 10.0 wt.-%, and

component B) is comprised in an amount of from 0.005 wt.-% to 30.0 wt.-%, and

optionally, component C), which is at least one selected from the group consisting of deodorant and antiperspirant active ingredients, is comprised in an amount of from 0.005 wt.-% to 25.0 wt.-%,

wherein the weight percentages refer to a total formulation.

9 . A method for preserving a formulation, the method comprising:

adding the following components to the formulation

A) n-heptyl-glyceryl ether, and

B) at least one selected from the group consisting of

p-anisic acid, benzoic acid, sorbic acid, lactic acid and salts of any of the before mentioned acids,

and phenylpropanol.

10 . The method according to claim 9 , wherein the preserving comprises growth reduction of a micro-organism.

11 . A preservative, comprising the composition according to claim 1 .

12 . A method for increasing critical micelle concentration of n-heptyl-glyceryl ether in water, the method comprising:

adding to the water and the n-heptyl-glyceryl ether, at least one selected from the group consisting of

B) p-anisic acid and salts thereof.

13 . The composition according to claim 6 , wherein the at least one antioxidant is tocopherol or naringenin.

14 . The method according to claim 9 , wherein the formulation is selected from the group consisting of cleaning formulations, defoamers, coating formulations, and cosmetic formulations.

15 . The method according to claim 10 , wherein the micro-organism is selected from the group consisting of yeast, mould, and bacteria.

16 . The method according to claim 10 , wherein the micro-organism is A. brasiliensis, S. aureus , or C. albicans.

17 . The preservative according to claim 11 , wherein the preservative is a preservative against a micro-organism selected from the group consisting of yeast, mould, and bacteria.

18 . The preservative according to claim 17 , wherein the preservative is a preservative against bacteria comprising A. brasiliensis, S. aureus , or C. albicans.

19 . The composition according to claim 1 , which has synergistic efficiency in antimicrobial activity.

20 . The composition according to claim 19 , wherein the antimicrobial activity is against is A. brasiliensis, S. aureus , or C. albicans.

Assignments (1)
MERGER Recorded Sep 15, 2025
From: EVONIK DR. STRAETMANS GMBH
To: EVONIK OPERATIONS GMBH
Reel/Frame 072259/0959 →
Priority Claims (1)
EP 20214820 · Dec 17, 2020 · regional
Continuity (1)
Related Publication 20240082123A1 · Mar 14, 2024
References Cited (19)
US 5736574A · Burnier et al. · 1998 [cited by applicant]
US 7416722B2 · Straetmans et al. · 2008 [cited by applicant]
US 7728168B2 · Jänichen et al. · 2010 [cited by applicant]
US 20060229291A1 · Straetmans et al. · 2006 [cited by applicant]
US 20090131712A1 · Janichen et al. · 2009 [cited by applicant]
US 20190254942A1 · Jänichen et al. · 2019 [cited by applicant]
EP 0747047 · 1996 [cited by applicant]
EP 1369471 · 2003 [cited by applicant]
EP 2807925 · 2014 [cited by examiner]
EP 2774481 · 2018 [cited by examiner]
WO 2014191258 · 2014 [cited by applicant]
WO WO2018033406 · 2018 [cited by examiner]
U.S. Pat. No. 7,416,722, filed Aug. 26, 2008, 2006/0229291, Straetmans et al. [cited by applicant]
U.S. Pat. No. 7,728,168, filed Jun. 1, 2010, 2009/0131712, Janichen et al. [cited by applicant]
U.S. Appl. No. 16/301,484, filed Nov. 14, 2018, 2019/0254942, Jänichen et al. [cited by applicant]
Extended European Search Report issued Jun. 22, 2021, received in European Patent Application No. 20214820.1, 7 pages. [cited by applicant]
International Search Report Issued Apr. 7, 2022, in PCT/EP2021/085425, 5 pages. [cited by applicant]
Karlheinz Schrader, “Grundlagen und Rezepturen der Kosmetika [Cosmetics—fundamentals and formulations]”, 2nd edition, 1989, pp. 329 to 341, Hüthig Buch Verlag Heidelberg. [cited by applicant]
Written Opinion issued Apr. 7, 2022, in PCT/EP2021/085425, 8 pages. [cited by applicant]