Methods of treating ovarian cancer with hemp extract

1. A method of treatment of ovarian cancer comprising:

a. forming an organoid from an ovarian cancer cell from a patient;

b. determining whether the organoid is sensitive to one or more chemotherapeutic agents by applying a test amount of at least one chemotherapeutic agent to the organoid; and

c. administering to the patient via an oral mucosal formulation, an effective amount of the at least one chemotherapeutic agent and concomitantly administering to the patient an effective amount of a composition comprising a cannabis extract (CE) wherein said cannabis extract comprises between 50% and 99% by weight of Cannabidiol (CBD).

2. The method of claim 1 wherein the CE is a broad spectrum hemp extract (BSHE) or a full spectrum hemp extract (FSHE) and wherein each of the BSHE or FSHE comprises 50% to 99% by weight of CBD and at least one other cannabinoid at a concentration of 0.1% to 10% wherein the at least one other cannabinoid is selected from the group consisting of:

Δ-9-tetrahydrocannabinol (Δ 9 -THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), Δ-8-tetrahydrocannabinol (Δ 8 -THC), cannabichromene (CBC), cannabichromene acid (CBCA), cannabigerol (CBG), cannabigerol acid (CBGA), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabicyclol (CBL), and combinations thereof.

3. The method of claim 2 wherein the CE comprises CBD at a concentration of between 60% and 99% and at least one other cannabinoid at a concentration of 0.1% to 10% wherein the at least one other cannabinoid is selected from the group consisting of: Δ-9-tetrahydrocannabinol (Δ 9 -THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), Δ-8-tetrahydrocannabinol (Δ 8 -THC), cannabichromene (CBC), cannabichromene acid (CBCA), cannabigerol (CBG), cannabigerol acid (CBGA), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabicyclol (CBL), and combinations thereof; and wherein the CE comprises a total concentration of cannabinoids of between 65% and 99%.

4. The method of claim 1 wherein the composition comprises at least one additional compound selected from the group consisting of: a terpene, a polyphenol, an essential fatty acid, a phytonutrient, and combinations thereof; and wherein the at least one additional compound makes up between 0.1% and 50% of the total weight of the composition.

5. The method of claim 1 wherein the composition comprises an oil or a fat as a carrier.

6. The method of claim 1 wherein the composition is administered at a pH of between 3.5 and 6.

7. The method of claim 1 wherein the chemotherapeutic agent and the CE are administered as one composition or as two different compositions.

8. The method of claim 1 wherein the chemotherapeutic agent is selected from the group consisting of: paclitaxel, altretamine, capecitabine, cyclosphosphamide, etoposide, gemcitabine, ifosfamide, itinotecan, doxorubicin, melphalan, pemetrexed, topotecan, binorelbine, carboplatin, cisplatin, docetaxel, fluorouracil, methotrexate, cetuximab, and combinations thereof.

9. The method of claim 1 wherein the ovarian cancer is a chemoresistant cancer.

10. The method of claim 1 wherein the effective amount of a chemotherapeutic agent is at least 50% less than an indicated individual dose and wherein the CE is administered at between 20 mg and 4,250 mg per day.

11. The method of claim 4 wherein the composition further comprises at least one terpene selected from the group consisting of: β-myrcene, β-caryophyllene, linalool, α-pinene, citral, D -limonene, eucalyptol, and combinations thereof.

12. The method of claim 4 wherein the composition further comprises at least one polyphenol selected from the group consisting of: a catechin, quercetin, cannflavin A/B/C, rutin, chlorogenic acid, and combinations thereof.

13. The method of claim 4 wherein the composition further comprises at least one fatty acid selected from the group consisting of: an omega 3 acid, an omega 6 acid, an omega 9 acid, and combinations thereof.

14. The method of claim 4 wherein the composition further comprises at least one phytonutrient wherein the phytonutrient is selected from the group consisting of: a tocopherol, a sterol, carotene, an aliphatic alcohol, a mineral, and combinations thereof.

15. The method of claim 1 further comprising:

i. at least one terpene selected from the group consisting of: β-myrcene, β-caryophyllene, linalool, α-pinene, citral, D -limonene, eucalyptol, and combinations thereof;

ii. at least one polyphenol selected from the group consisting of: catechins, quercetin, cannflavin A/B/C, rutin, chlorogenic acid, and combinations thereof;

iii. at least one essential fatty acid selected from the group consisting of: an omega 3, an omega 6, an omega 9, and combinations thereof; and

iv. at least one phytonutrient selected from the group consisting of: a tocopherol, a sterol, carotene, an aliphatic alcohol, a mineral, and combinations thereof.

16. A method of treatment of ovarian cancer comprising:

a. forming an organoid from an ovarian cancer cell from a patient;

b. determining whether the organoid is sensitive to one or more chemotherapeutic agents by applying a test amount of at least one chemotherapeutic agent to the organoid; and

c. administering to the patient via an intravaginal formulation, an effective amount of the at least one chemotherapeutic agent and concomitantly administering to the patient an effective amount of a composition comprising a cannabis extract (CE) wherein said cannabis extract comprises between 50% and 99% by weight of CBD.