IP Library Granted Patent US 12,648,930
Granted Patent B2
US 12,648,930 · App. 18/331,688 · Granted Jun 9, 2026

Compositions and methods for treating ocular disorders

Inventors: Tina deVries (Longmont, CO); David Jacobs (Bernardsville, NJ)
Assignee: RVL Pharmaceuticals, Inc.
A61K31/4164A61F9/0008A61K9/0048A61K47/02A61K47/12A61K47/38A61P27/02
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Quick Facts
Patent No.
US 12,648,930
App. No.
18/331,688
Granted
Jun 9, 2026
Kind
B2
Abstract

The present disclosure is directed to compositions comprising oxymetazoline and methods of treating various eye disorders related to drooping eyelids, such as ptosis, in a subject comprising administering to the subject compositions comprising oxymetazoline.

Claims (66)

1 . A method of increasing the vertical separation of the upper eyelid and lower eyelid of at least one eye in a subject, comprising administering to at least one eye of the subject an aqueous ophthalmic, sterile, preservative-free stable formulation consisting of:

a) about 0.1 wt % oxymetazoline hydrochloride;

b) about 0.64 wt % sodium chloride;

c) about 0.075 wt % potassium chloride;

d) about 0.048 wt % calcium chloride;

e) about 0.03 wt % magnesium chloride;

f) one or more suitable buffers;

g) about 0.5 wt % hypromellose;

h) hydrochloric acid; and

i) water;

wherein the formulation has a pH range from about 5.8 to about 6.8, and

wherein the formulation maintains the pH range from about 5.8 to about 6.8 for a period of 24 months.

2 . The method of claim 1 , wherein the formulation comprises from about 0.05 wt % to about 1.0 wt % one or more suitable buffers.

3 . The method of claim 2 , wherein the one or more suitable buffers comprise sodium acetate and sodium citrate.

4 . The method of claim 3 , wherein the one or more suitable buffers comprise about 0.39 wt % sodium acetate and about 0.17 wt % sodium citrate.

5 . The method of claim 4 , wherein the sodium acetate is sodium acetate trihydrate and the sodium citrate is sodium citrate dihydrate.

6 . The method of claim 1 , wherein the calcium chloride is calcium chloride dihydrate and the magnesium chloride is magnesium chloride hexahydrate.

7 . The method of claim 1 , wherein the formulation has a pH range from about 6.3 to about 6.5.

8 . The method of claim 1 , wherein the formulation has a viscosity of from about 15 cPs to about 35 cPs.

9 . The method of claim 1 , wherein the formulation has an osmolality of from about 290 mOsm/kg to about 365 mOsm/kg.

10 . The method of claim 1 , wherein the formulation maintains a pH range from about 5.8 to about 6.8, a viscosity from about 15 cPs to about 35 cPs, and an osmolality from about 290 to about 365 mOsm/kg for a period of 24 months.

11 . The method of claim 1 , wherein the formulation is administered to the subject on one or more consecutive days at a dose of one drop in a single eye for a total daily dose of about 0.035 mg oxymetazoline hydrochloride.

12 . The method of claim 1 , wherein the formulation is administered to the subject on one or more consecutive days at a dose of one drop in each eye for a total daily dose of about 0.07 mg oxymetazoline hydrochloride.

13 . A method of increasing the vertical separation of the upper eyelid and lower eyelid of at least one eye in a subject, comprising administering to at least one eye of the subject an aqueous ophthalmic, sterile, preservative-free stable formulation consisting of:

a) about 0.1 wt % oxymetazoline hydrochloride;

b) about 0.64 wt % sodium chloride;

c) about 0.075 wt % potassium chloride;

d) about 0.048 wt % calcium chloride;

e) about 0.03 wt % magnesium chloride;

f) about 0.39 wt % sodium acetate;

g) about 0.17 wt % sodium citrate;

h) a viscosity modifier;

i) hydrochloric acid; and

j) water;

wherein the formulation has a viscosity of from about 15 cPs to about 35 cPs, and

wherein the formulation maintains the viscosity from about 15 cPs to about 35 cPs for a period of 24 months.

14 . The method of claim 13 , wherein the viscosity modifier comprises hypromellose.

15 . The method of claim 14 , wherein the formulation comprises about 0.5 wt % hypromellose.

16 . The method of claim 13 , wherein the sodium acetate is sodium acetate trihydrate and the sodium citrate is sodium citrate dihydrate.

17 . The method of claim 13 , wherein the calcium chloride is calcium chloride dihydrate and the magnesium chloride is magnesium chloride hexahydrate.

18 . The method of claim 13 , wherein the formulation has a pH range from about 5.8 to about 6.8.

19 . The method of claim 13 , wherein the formulation has a pH range from about 6.3 to about 6.5.

20 . The method of claim 13 , wherein the formulation has an osmolality of from about 290 mOsm/kg to about 365 mOsm/kg.

21 . The method of claim 13 , wherein the formulation maintains a pH range from about 5.8 to about 6.8, a viscosity from about 15 cPs to about 35 cPs, and an osmolality from about 290 to about 365 mOsm/kg for a period of 24 months.

22 . The method of claim 13 , wherein the formulation is administered to the subject on one or more consecutive days at a dose of one drop in a single eye for a total daily dose of about 0.035 mg oxymetazoline hydrochloride.

23 . The method of claim 13 , wherein the formulation is administered to the subject on one or more consecutive days at a dose of one drop in each eye for a total daily dose of about 0.07 mg oxymetazoline hydrochloride.

24 . A method of increasing the vertical separation of the upper eyelid and lower eyelid of at least one eye in a subject, comprising administering to at least one eye of the subject an aqueous ophthalmic, sterile, preservative-free stable formulation consisting of:

a) about 0.1 wt % oxymetazoline hydrochloride;

b) one or more tonicity modifiers;

c) about 0.39 wt % sodium acetate;

d) about 0.17 wt % sodium citrate;

e) about 0.5 wt % hypromellose;

f) hydrochloric acid; and

g) water;

wherein the formulation has an osmolality of from about 290 mOsm/kg to about 365 mOsm/kg, and

wherein the formulation maintains the osmolality from about 290 mOsm/kg to about 365 mOsm/kg for a period of 24 months.

25 . The method of claim 24 , wherein the one or more tonicity modifiers comprise sodium chloride, potassium chloride, calcium chloride, and/or magnesium chloride.

26 . The method of claim 24 , wherein the one or more the tonicity modifiers comprise about 0.64 wt % of sodium chloride, about 0.075 wt % of potassium chloride, about 0.048 wt % of calcium chloride, and about 0.03 wt % of magnesium chloride.

27 . The method of claim 25 , wherein the calcium chloride is calcium chloride dihydrate and the magnesium chloride is magnesium chloride hexahydrate.

28 . The method of claim 24 , wherein the sodium acetate is sodium acetate trihydrate and the sodium citrate is sodium citrate dihydrate.

29 . The method of claim 24 , wherein the formulation has a pH range from about 5.8 to about 6.8.

30 . The method of claim 24 , wherein the formulation has a pH range from about 6.3 to about 6.5.

31 . The method of claim 24 , wherein the formulation has a viscosity of from about 15 cPs to about 35 cPs.

32 . The method of claim 24 , wherein the formulation maintains a pH range from about 5.8 to about 6.8, a viscosity from about 15 cPs to about 35 cPs, and an osmolality from about 290 to about 365 mOsm/kg for a period of 24 months.

33 . The method of claim 24 , wherein the formulation is administered to the subject on one or more consecutive days at a dose of one drop in a single eye for a total daily dose of about 0.035 mg oxymetazoline hydrochloride.

34 . The method of claim 24 , wherein the formulation is administered to the subject on one or more consecutive days at a dose of one drop in each eye for a total daily dose of about 0.07 mg oxymetazoline hydrochloride.

Assignments (3)
CHANGE OF NAME Recorded May 21, 2025
From: REVITALID, INC.
To: RVL PHARMACEUTICALS, INC.
Reel/Frame 071344/0448 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 21, 2025
From: DEVRIES, TINA; JACOBS, DAVID
To: REVITALID, INC.
Reel/Frame 071351/0026 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Nov 27, 2023
From: RVL PHARMACEUTICALS, INC.
To: ATHYRIUM OPPORTUNITIES IV ACQUISITION LP, AS ADMINISTRATIVE AGENT
Reel/Frame 065676/0617 →
Continuity (7)
Continuation 17662494 · May 9, 2022
Continuation 17194559 · Mar 8, 2021
Continuation 17063416 · Oct 5, 2020
Continuation 16716014 · Dec 16, 2019
Provisional Application 62843819 · May 6, 2019
Provisional Application 62844069 · May 6, 2019
Related Publication 20240033250A1 · Feb 1, 2024
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