IP Library Granted Patent US 12,582,989
Granted Patent B2
US 12,582,989 · App. 18/337,140 · Granted Mar 24, 2026

Production of chemical reactors

Inventors: Jeff Op De Beeck (Mariakerke, BE); Paul Jacobs (Lokeren, BE); Wim De Malsche (Berchem, BE)
Assignee: PharmaFluidics NV
B01L3/502753B01D15/22B01D53/025B01L3/502707B01L3/502746B01L2300/0816B01L2300/0864B01L2400/086G01N30/6095
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Quick Facts
Patent No.
US 12,582,989
App. No.
18/337,140
Granted
Mar 24, 2026
Kind
B2
Abstract

A method for producing a chemical reactor. The chemical reactor comprises one or more effective channels which comprise pillar structures, an input connected to one of the effective channels to allow fluid/gas into the effective channels and an output connected to one of the effective channels to remove at least one component of the liquid/gas. The method comprises obtaining an initial design of the reactor, further introducing into the initial design at least a structured area positioned adjacent to an effective channel of the one or more effective channels located at the edge of the initial design, the structured area not being fluidly connected to one of the effective channels, to obtain a further design and the production of the reactor according to the further design.

Claims (14)

1 . A chemical reactor implemented on a substrate, the chemical reactor comprising:

one or more effective channels for transporting a liquid and/or gas during use of the chemical reactor, the effective channels comprising pillar structures;

an input connected to one of the one or more effective channels to allow the liquid and/or gas into the effective channels;

an output connected to one of the one or more effective channels to remove at least one component of the liquid and/or gas from the effective channels; and

a structured area positioned adjacent to an effective channel of the one or more effective channels located at an edge of the chemical reactor, the structured area not being fluidly connected to the one or more effective channels, and the structured area including a dummy channel, the dummy channel being a channel that has no connection to the one or more effective channels and that has no input or output.

2 . The chemical reactor according to claim 1 , the dummy channel being positioned at less than 150 μm from the effective channel of the one or more effective channels.

3 . The chemical reactor according to claim 1 , the one or more effective channels comprising a plurality of substantially parallel effective channels, the plurality of effective channels being fluidly interconnected in a meandering structure.

4 . The chemical reactor according to claim 1 , the dummy channel having a depth equal to the depth of the effective channels or a depth smaller or greater than the depth of the effective channels.

5 . The chemical reactor according to claim 1 , wherein the dummy channel is implemented next to a first effective channel of the one or more effective channels, the dummy channel having the same design as a second effective channel of the one or more effective channels that is positioned on the other side of the first effective channel.

6 . The chemical reactor according to claim 1 , the dummy channel comprising pillar structures.

7 . The chemical reactor according to claim 1 , wherein the production of the chemical reactor comprises one or more chip manufacturing steps.

8 . The chemical reactor according to claim 6 , wherein the pillar structures comprise porous pillar structures.

9 . The chemical reactor of claim 1 , wherein the chemical reactor is a chromatographic column.

10 . The chemical reactor of claim 1 , wherein the dummy channel is implemented next to a first effective channel of the one or more effective channels, the dummy channel having a same width as a second effective channel of the one or more effective channels that is positioned on the other side of the first effective channel.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 31, 2023
From: OP DE BEECK, JEFF; JACOBS, PAUL; DE MALSCHE, WIM
To: PHARMAFLUIDICS NV
Reel/Frame 064765/0137 →
MERGER Recorded Aug 31, 2023
From: PHARMAFLUIDICS NV
To: THERMO FISHER SCIENTIFIC BV
Reel/Frame 064789/0604 →
Priority Claims (1)
BE 2016/5556 · Jul 4, 2016 · national
Continuity (2)
Division 16315217
Related Publication 20230330674A1 · Oct 19, 2023
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