System for treating embolism and associated devices and methods
Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.
1. A method for the intravascular treatment of clot material from within a blood vessel of a human patient, the method comprising:
positioning a first catheter within a second catheter such that a distal portion of the first catheter is at a treatment site proximate to the clot material within the blood vessel;
coupling a first pressure source to the first catheter via a fluid control device, wherein (a) opening of the fluid control device fluidly connects the first pressure source to the first catheter and (b) closing of the fluid control device fluidly disconnects the first pressure source from the first catheter;
activating the first pressure source to generate a vacuum while the fluid control device is closed;
opening the fluid control device to apply the vacuum to the first catheter to thereby aspirate at least a portion of the clot material into the first catheter;
coupling a second pressure source to the second catheter; and
activating the second pressure source to generate suction at the distal portion of the second catheter.
2. The method of claim 1 wherein positioning the first catheter within the second catheter includes advancing the first catheter through the second catheter after positioning the second catheter within the blood vessel.
3. The method of claim 1 wherein positioning the first catheter within the second catheter includes advancing the second catheter over the first catheter after positioning the first catheter within the blood vessel.
4. The method of claim 1 wherein the first catheter has a size of 16 French, and wherein the second catheter has a size of 24 French.
5. The method of claim 1 wherein the first catheter has a first length, and wherein the second catheter has a second length shorter than the first length.
6. The method of claim 1 wherein the first pressure source is the same as the second pressure source.
7. The method of claim 1 wherein the first pressure source and the second pressure source comprise an electric pump.
8. The method of claim 1 wherein activating the second pressure source includes activating the second pressure source after opening the fluid control device to apply the vacuum to the first catheter.
9. The method of claim 1 wherein activating the second pressure source includes activating the second pressure source before opening the fluid control device to apply the vacuum to the first catheter.
10. The method of claim 1 wherein positioning the first catheter within the second catheter includes inserting the first catheter through a hemostasis valve coupled to a proximal portion of the second catheter.
11. The method of claim 10 wherein the method further comprises depressing a button of the hemostasis valve to unseal a lumen of the hemostasis valve while inserting the first catheter through the hemostasis valve.
12. The method of claim 1 wherein positioning the first catheter within the second catheter includes positioning the distal portion of the first catheter distal of a distal end portion of the second catheter.
13. The method of claim 1 wherein the first pressure source is a first syringe, and wherein the second pressure source is a second syringe.
14. The method of claim 1 wherein the clot material comprises a pulmonary embolism.
15. The method of claim 1 wherein the clot material comprises a deep vein thrombus.
16. The method of claim 1 wherein—
the fluid control device is a first fluid control device,
coupling the second pressure source to the second catheter includes coupling the second pressure source to the second catheter via a second fluid control device,
opening of the second fluid control device fluidly connects the second pressure source to the second catheter, and
closing of the second fluid control device fluidly disconnects the second pressure source from the second catheter.
17. The method of claim 16 wherein activating the second pressure source to generate suction at the distal portion of the second catheter comprises:
activating the second pressure source to generate a vacuum while the second fluid control device is closed; and
opening the second fluid control device to apply the vacuum to the second catheter to thereby generate the suction at the distal portion of the second catheter.
18. A method for the intravascular treatment of clot material from within a blood vessel of a human patient, the method comprising:
positioning a first catheter within a second catheter within the blood vessel;
coupling a first pressure source to the first catheter via a first fluid control device, wherein (a) opening of the first fluid control device fluidly connects the first pressure source to the first catheter and (b) closing of the first fluid control device fluidly disconnects the first pressure source from the first catheter;
coupling a second pressure source to the second catheter via a second fluid control device, wherein (a) opening of the second fluid control device fluidly connects the second pressure source to the second catheter and (b) closing of the second fluid control device fluidly disconnects the second pressure source from the second catheter;
activating the first pressure source to generate a first vacuum while the first fluid control device is closed;
activating the second pressure source to generate a second vacuum while the second fluid control device is closed;
opening the first fluid control device to apply the first vacuum to the first catheter to thereby aspirate at least a first portion of the clot material into the first catheter; and
opening the second fluid control device to apply the second vacuum to the second catheter to thereby aspirate at least a second portion of the clot material into the second catheter.
19. The method of claim 18 wherein positioning the first catheter within the second catheter includes advancing the first catheter through the second catheter after positioning the second catheter within the blood vessel, and wherein opening the first fluid control device includes opening the first fluid control device to apply the first vacuum to the first catheter after opening the second fluid control device to apply the second vacuum to the second catheter.
20. The method of claim 18 wherein the first pressure source and the second pressure source comprise an electric pump, and wherein positioning the first catheter within the second catheter includes inserting the first catheter through a hemostasis valve coupled to a proximal portion of the second catheter.
21. The method of claim 1 wherein positioning the first catheter within the second catheter includes positioning the distal portion of the first catheter distal of a distal end portion of the second catheter.