Functional beverage containing 1,3 butanediol
View Patent ↗A beverage can include D ethyl 3-hydroxybutyrate, D 1,3-butanediol, D Beta hydroxybutyrate salts, D Beta hydroxybutyrate/D 1,3-butanediol monoester, D ethyl hydroxybutyrate, hydroxybutyrate, and/or D hydroxybutyric acid of at least 0.5 percent by volume. The percentage of D ethyl 3-hydroxybutyrate, D 1,3-butanediol, D Beta hydroxybutyrate salts, D Beta hydroxybutyrate/D 1,3-butanediol monoester, D ethyl hydroxybutyrate, hydroxybutyrate, and D hydroxybutyric acid can be between 5 and 19 percent, or can be higher than 19 percent. The beverage can be improved by the incorporation of flavor from hops and/or from other ingredients.
1. A method of increasing ketone bodies exposure in a subject, the method comprising administering a beverage comprising water and at least 0.5 percent by volume D-1,3-butanediol and no, or substantially no, L-1,3-butanediol;
the beverage further optionally comprising one or more additives selected from the group consisting of D ethyl 3-hydroxybutyrate; D beta hydroxybutyrate salts; D beta hydroxybutyrate, D 1,3-butanediol monoester; 3-hydroxy-, 3-ethoxy-1-methyl-3-oxopropyl ester; D hydroxybutyric acid; ethanol; and combinations thereof;
and
wherein the blood levels of ketone bodies is increased above 0.5 mmol/L.
2. The method of claim 1 , wherein the beverage further comprises a substrate.
3. The method of claim 2 , wherein the beverage wherein the substrate comprises one or more flavoring agents.
4. The method of claim 1 , wherein the D-1,3-butanediol is present at a concentration of greater than 5 percent by volume.
5. The method of claim 1 , wherein the D-1,3-butanediol is present at a concentration of greater than 19 percent by volume.
6. The method of claim 1 , wherein the one or more additives are each partially or fully racemic.
7. The method of claim 1 , wherein the beverage is fermented.
8. The method of claim 1 , wherein the ethanol is not optional and is present at a concentration of less than 0.5 percent by volume.
9. The method of claim 1 , wherein the beverage is carbonated.
10. The method of claim 1 , wherein the beverage comprises less than 10 g of carbohydrates per serving.
11. A method of maintaining ketone bodies exposure in a subject, the method comprising administering a beverage comprising water and at least 0.5 percent by volume D-1,3-butanediol and no, or substantially no, L-1,3-butanediol;
the beverage further optionally comprising one or more additives selected from the group consisting of D ethyl 3-hydroxybutyrate; D beta hydroxybutyrate salts; D beta hydroxybutyrate, D 1,3-butanediol monoester; 3-hydroxy-, 3-ethoxy-1-methyl-3-oxopropyl ester; D hydroxybutyric acid; ethanol; and combinations thereof;
and
wherein the blood levels of ketone bodies is maintained above 0.5 mmol/L.
12. The method of claim 11 , wherein the beverage further comprises a substrate.
13. The method of claim 12 , wherein the substrate comprises one or more flavoring agents.
14. The method of claim 11 , wherein the D-1,3-butanediol is present at a concentration of greater than 5 percent by volume.
15. The method of claim 11 , wherein the D-1,3-butanediol is present at a concentration of greater than 19 percent by volume.
16. The method of claim 11 , wherein the one or more additives are each partially or fully racemic.
17. The method of claim 11 , wherein the beverage is carbonated.
18. The method of claim 11 , wherein the beverage comprises less than 10 g of carbohydrates per serving.