IP Library Granted Patent US 12,460,731
Granted Patent B2
US 12,460,731 · App. 18/405,525 · Granted Nov 4, 2025

Valve assembly with directional flow path

Inventors: Michael C. Gagne (Carson City, NV); Steven V. Cates (Lakewood, CA); Dean C. Richards (Simi Valley, CA); Scott Bendon (Wales, GB)
Assignee: Repligen Corporation
F16K11/22B29C45/14614B29C66/01F16K7/06F16K7/07F16K27/003F16K27/0236F16B13/00
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Quick Facts
Patent No.
US 12,460,731
App. No.
18/405,525
Granted
Nov 4, 2025
Kind
B2
Abstract

A valve assembly with a multidirectional flow path includes a valve body that includes respective hinged portions defining respective passageways extending through the valve body when in a closed state. A flexible conduit or tubing having a loop portion and a plurality of branches extending from the loop portion is at least partially positioned within the valve body. Portions of the loop that extend beyond the valve body are encapsulated by respective rigid jackets. Multiple valves are situated on the valve body and are used to selectively pinch the loop portion in different pinching configurations to direct fluid to or from the particular branches. The valve assembly may be integrated into a manufacturing or other production process with optional additional jackets used to encapsulate the flexible conduit branches.

Claims (29)

1 . A valve assembly with a multidirectional flow path comprising:

a valve body comprising a first body portion and a second body portion connected to one another at one or more hinges, the first body portion and the second body portion defining passageways extending through the valve body when in a closed state;

a flexible conduit having at least a portion thereof extending through the passageways of the valve body, the flexible conduit comprising:

a first branch comprising a first tee segment;

a second branch;

a third branch comprising a second tee segment;

a fourth branch; and

a connector segment between the second branch and the fourth branch;

wherein a loop portion is connected to the first tee segment of the first branch via first and second overmolded connectors, and is connected to the second tee segment of the third branch via third and fourth overmolded connectors;

a plurality of valves disposed on the valve body, each of the plurality of valves including an associated pinching element; and

a plurality of actuators associated with the plurality of valves, the plurality of actuators configured to actuate the pinching element associated with each of the plurality of valves to move the pinching element through a respective aperture in the first or second body portion and into one of the passageways;

wherein:

the plurality of valves includes a first valve including a first actuator associated with a first pinching element, a second valve including a second actuator associated with a second pinching element, a third valve including a third actuator associated with a third pinching element, a fourth valve including a fourth actuator associated with a fourth pinching element, and a fifth valve including a fifth actuator associated with a fifth pinching element;

the first pinching element configured to pinch the flexible conduit loop between the first branch and the second branch at a location in the flexible conduit positioned between the first overmolded connector and the third overmolded connector;

the second pinching element configured to pinch the flexible conduit loop between the second branch and the third branch at a location in the flexible conduit positioned between the first overmolded connector and the third overmolded connector;

the third pinching element configured to pinch the flexible conduit loop between the third branch and the fourth branch at a location in the flexible conduit positioned between the second overmolded connector and the fourth overmolded connector;

the fourth pinching element configured to pinch the flexible conduit loop between the fourth branch and the first branch at a location in the flexible conduit positioned between the second overmolded connector and the fourth overmolded connector; and

the fifth pinching element configured to pinch the flexible conduit in the connector segment.

2 . The valve assembly of claim 1 , wherein the plurality of valves are disposed on the first body portion.

3 . The valve assembly of claim 1 , wherein at least one of the plurality of valves is disposed on the first body portion and at least one of the plurality of valves is disposed on the second body portion.

4 . The valve assembly of claim 1 , wherein the actuators are manually actuatable.

5 . The valve assembly of claim 1 , wherein the actuators are automatically actuatable.

6 . The valve assembly of claim 1 , wherein a first portion of the loop extends outside the valve body and is contained in a first rigid jacket and a second portion of the loop extends outside the valve body and is contained in a second rigid jacket, the first and second rigid jackets configured to receive the flexible conduit.

7 . The valve assembly of claim 6 , wherein the valve body comprises a metal material and the first and second rigid jackets comprise a polymer material.

8 . The valve assembly of claim 6 , wherein the first and second rigid jackets comprise hinged jackets.

9 . The valve assembly of claim 6 , wherein the first rigid jacket and the second rigid jacket each comprise respective halves secured to one another via a fastener.

10 . The valve assembly of claim 6 , wherein the first rigid jacket and the second rigid jacket are secured within respective recesses formed in the first body portion and a second body portion of the valve body.

11 . The valve assembly of claim 6 , wherein the first and second rigid jackets each comprise respective posts that extend into respective apertures or holes formed in at least one of the first and second body portions of the valve body.

12 . The valve assembly of claim 1 , wherein the first valve, the second valve, the third valve, and the fourth valve are positioned less than 1 centimeter from an adjacent intersecting or adjacent flow path or fluid pathway to minimize any hold up volume of fluid within the loop.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2024
From: ALPHINITY, LLC
To: REPLIGEN CORPORATION
Reel/Frame 068636/0413 →
Continuity (4)
Continuation 16930300 · Jul 15, 2020
Continuation 15763057
Provisional Application 62236007 · Oct 1, 2015
Related Publication 20240133472A1 · Apr 25, 2024
References Cited (88)
US 2825524A · Fox · 1958 [cited by applicant]
US 2931387A · Fleming · 1960 [cited by applicant]
US 3468342A · Craft · 1969 [cited by applicant]
US 3559683A · Maguire · 1971 [cited by applicant]
US 4254797A · Mayeaux · 1981 [cited by examiner]
US 4274452A · Schmitt · 1981 [cited by applicant]
US 4337791A · Tech · 1982 [cited by examiner]
US 4457339A · Juan · 1984 [cited by applicant]
US 4559045A · Danby · 1985 [cited by examiner]
US 4618114A · McFarland · 1986 [cited by applicant]
US 4895341A · Brown · 1990 [cited by applicant]
US 4993456A · Sule · 1991 [cited by applicant]
US 5098060A · Mogler · 1992 [cited by examiner]
US 5197708A · Campau · 1993 [cited by applicant]
US 5350290A · Honings · 1994 [cited by applicant]
US 5402823A · Cole · 1995 [cited by applicant]
US 5549134A · Browne · 1996 [cited by applicant]
US 5901745A · Buchtel · 1999 [cited by applicant]
US 5906223A · Pinkham · 1999 [cited by applicant]
US 6016839A · Raftis · 2000 [cited by examiner]
US 6036166A · Olson · 2000 [cited by applicant]
US 6068751A · Neukermans · 2000 [cited by applicant]
US 6543483B2 · Johnson · 2003 [cited by applicant]
US 6554589B2 · Grapes · 2003 [cited by applicant]
US 6631736B2 · Seitz · 2003 [cited by applicant]
US 6644353B1 · Eidsmore · 2003 [cited by applicant]
US 6976664B2 · Welch · 2005 [cited by examiner]
US 7104275B2 · Dille · 2006 [cited by applicant]
US 7367363B2 · Friedline · 2008 [cited by applicant]
US 7383853B2 · Welch · 2008 [cited by applicant]
US 8235067B2 · Gagne · 2012 [cited by applicant]
US 8376046B2 · Broussard, II · 2013 [cited by examiner]
US 8656951B2 · Gagne · 2014 [cited by applicant]
US 9447888B2 · Gagne · 2016 [cited by applicant]
US 9546747B2 · Hofmann · 2017 [cited by applicant]
US 20040163711A1 · Varone · 2004 [cited by applicant]
US 20060048818A1 · Welch · 2006 [cited by examiner]
US 20070278155A1 · Lo · 2007 [cited by applicant]
US 20070295867A1 · Hennon · 2007 [cited by applicant]
US 20080035227A1 · Woods · 2008 [cited by applicant]
US 20080237509A1 · Yamamoto · 2008 [cited by applicant]
US 20080277015A1 · Tanaka · 2008 [cited by examiner]
US 20090120503A1 · Donahue · 2009 [cited by applicant]
US 20090188113A1 · McKeeth · 2009 [cited by applicant]
US 20090243284A1 · Klingel, Jr. · 2009 [cited by applicant]
US 20100288385A1 · Gagne · 2010 [cited by examiner]
US 20120017733A1 · Gay · 2012 [cited by applicant]
US 20120018654A1 · Wennberg · 2012 [cited by examiner]
US 20120325859A1 · Malin · 2012 [cited by examiner]
US 20140224335A1 · Hofmann · 2014 [cited by applicant]
CN 102317054A · 2012 [cited by applicant]
CN 202778069U · 2013 [cited by applicant]
DE 102004006889B3 · 2005 [cited by applicant]
GB 1055426A · 1967 [cited by applicant]
JP 2004293769A · 2004 [cited by applicant]
JP 2013008570A · 2013 [cited by applicant]
WO 9711296A1 · 1997 [cited by applicant]
WO 2010132435A1 · 2010 [cited by applicant]
WO 2015109209A2 · 2015 [cited by applicant]
Response to extended European Search Report dated Dec. 19, 2019 for European Application No. 16852791.9, (4 pages). [cited by applicant]
Communication pursuant to Article 94(3) EPC dated Jun. 29, 2020 for European Application No. 16852791.9, (6 pages). [cited by applicant]
Reply to communication pursuant to Article 94(3) EPC dated Oct. 29, 2020 for European Application No. 16852791.9, (43 pages). [cited by applicant]
Notification of Second Office Action dated Jan. 3, 2020 for Chinese Application No. 2016800573087, (17 pages). [cited by applicant]
Response to Second Office Action dated May 15, 2020 for Chinese Application No. 2016800573087, (10 pages). [cited by applicant]
Notification of Third Office Action dated Jun. 1, 2020 for Chinese Application No. 2016800573087, (9 pages). [cited by applicant]
Response to Third Office Action dated Oct. 16, 2020 for Chinese Application No. 2016800573087, (4 pages). [cited by applicant]
First Office Action dated Aug. 4, 2020 for Japanese Patent Application No. 2018-516160, (12 pages). [cited by applicant]
Response to First Office Action dated Nov. 2, 2020 for Japanese Patent Application No. 2018-516160, (9 pages). [cited by applicant]
PCT International Search Report for PCT/US2016/055016, Applicant: Alphinity, LLC, Form PCT/ISA/210 and 220, dated Feb. 9, 2017 (7pages). [cited by applicant]
PCT Written Opinion of the International Search Authority for PCT/US2016/055016, Applicant: Alphinity, LLC, Form PCT/ISA/237, dated Feb. 9, 2017 (7pages). [cited by applicant]
PCT International Search Report for PCT/US2016/051714, Applicant: Alphinity, LLC, Form PCT/ISA/210 and 220, dated Dec. 7, 2016 (4pages). [cited by applicant]
PCT Written Opinion of the International Search Authority for PCT/US2016/051714, Applicant: Alphinity LLC, Form PCT/ISA/237, dated Dec. 7, 2016 (9pages). [cited by applicant]
The extended European search report dated Nov. 29, 2016 in European Application No. 10775392.3-1751, Applicant: Alphinity, LLC, (10pages). [cited by applicant]
Notice of Preliminary Rejection dated Dec. 14, 2016 in Korean Patent Application No. 10-2011-7027072, (11pages). [cited by applicant]
Communication from European Patent Office dated Nov. 6, 2017 in European Patent Application No. 10775392.3-1751, (7pages). [cited by applicant]
PCT International Preliminary Report on Patentability (Chapter I of the Patent Cooperation Treaty) for PCT/US2016/055016, Applicant: Alphinity, LLC., Form PCT/IB/326 and 373, dated Apr. 12, 2018 (9pages). [cited by applicant]
Notification of First Office Action dated Apr. 1, 2019 in Chinese Application No. 2016800573087, (10 pages). [cited by applicant]
Response to First Office Action dated Aug. 15, 2019 in Chinese Application No. 2016800573087, including English translation of claims only (35 pages). [cited by applicant]
The extended European Search Report dated May 31, 2019 in European Application No. 16852791.9, (6 pages). [cited by applicant]
Communication pursuant to Rules 70(2) and 70a(2) EPC dated Jun. 18, 2019 in European Application No. 16852791.9, (1 page). [cited by applicant]
Invitation to Respond to Written Opinion dated May 30, 2019 in Singapore Application No. 11201802254R, (11 pages). [cited by applicant]
Invitation to Respond to Written Opinion dated Oct. 8, 2019 in Singapore Application No. 11201802254R, (18 pages). [cited by applicant]
BioWorks LLC Product Brochure (date: unknown), BSC: Bio Sample Cup, Safe, Sanitary Material Storage, Easton, PA 18042, www.BioWorksLLC.com (6 pages). [cited by applicant]
Parker Mitos Product Brochure, Mitos Free Flow Valve, Apr. 29, 2009, http://www.mitostech.com/freelow.html (2 pages). [cited by applicant]
PCT International Search Report for PCT/US10/34371, Applicant: AlphaBio, Inc., Form PCT/ISA/210 and 220, dated Jul. 1, 2010 (4 pages). [cited by applicant]
PCT Written Opinion of the International Search Authority for PCT/US10/34371, Applicant: AlphaBio, Inc., Form PCT/ISA/237, dated Jul. 1, 2010 (7 pages). [cited by applicant]
PCT International Preliminary Report on Patentability (Chapter I of the Patent Cooperation Treaty) for PCT/US2010/034371, Applicant: AlphaBio, Inc., Form PCT/IB/326 and 373, dated Nov. 15, 2011 (9 pages). [cited by applicant]
BioWorks LLC Catalog, Model: BSV-H250-Bo, www.BioWorksLLC.com, cited in U.S. Appl. No. 14/165,206 dated Aug. 25, 2014 (6pages). [cited by applicant]