Combination therapies using immuno-DASH inhibitors and PGE2 antagonists
Disclosed are combination therapies including administration of I-DASH inhibitors and PGE2 antagonists, and the use of such therapies in the treatment of cell proliferative diseases.
1 . A method of enhancing an immune response against a tumor, comprising administering to a subject in need thereof a therapeutically effective amount of:
a COX-2 inhibitor selected from the group consisting of celecoxib, deracoxib, parecoxib, valdecoxib, rofecoxib, lumiracoxib, etoricoxib, and meloxicam; or a pharmaceutically acceptable salt thereof; and
Val-boroPro or a pharmaceutically acceptable salt thereof.
2 . The method of claim 1 , wherein the COX-2 inhibitor is celecoxib.
3 . The method of claim 1 , wherein the COX-2 inhibitor is rofecoxib.
4 . The method of claim 1 , wherein Val-boroPro is administered.
5 . The method of claim 1 , wherein a pharmaceutically acceptable salt of Val-boroPro is administered.
6 . The method of claim 5 , wherein the pharmaceutically acceptable salt of Val-boroPro is Val-boroPro mesylate.
7 . The method of claim 1 , wherein the tumor is basal cell carcinoma, biliary tract cancer, bladder cancer, bone cancer, brain cancer, breast cancer, cervical cancer, choriocarcinoma, CNS cancer, colon and rectum cancer, connective tissue cancer, cancer of the digestive system, endometrial cancer, esophageal cancer, eye cancer, cancer of the head and neck, gastric cancer, intra-epithelial neoplasm, kidney cancer, larynx cancer, leukemia, acute myeloid leukemia, acute lymphoid leukemia, chronic myeloid leukemia, chronic lymphoid leukemia, liver cancer, small cell lung cancer, non-small cell lung cancer, lymphoma, Hodgkin's lymphoma, Non-Hodgkin's lymphoma, melanoma, myeloma, myeloproliferative disease, neuroblastoma, oral cavity cancer, ovarian cancer, pancreatic cancer, prostate cancer, retinoblastoma, rhabdomyosarcoma, rectal cancer, renal cancer, cancer of the respiratory system, sarcoma, skin cancer, stomach cancer, testicular cancer, thyroid cancer, uterine cancer, or cancer of the urinary system.
8 . The method of claim 7 , wherein the COX-2 inhibitor is celecoxib.
9 . The method of claim 7 , wherein the COX-2 inhibitor is rofecoxib.
10 . The method of claim 7 , wherein Val-boroPro is administered.
11 . The method of claim 7 , wherein a pharmaceutically acceptable salt of Val-boroPro is administered.
12 . The method of claim 11 , wherein the pharmaceutically acceptable salt of Val-boroPro is Val-boroPro mesylate.
13 . The method of claim 1 , wherein the tumor is acute myeloid leukemia (AML).
14 . The method of claim 13 , wherein the COX-2 inhibitor is celecoxib.
15 . The method of claim 13 , wherein the COX-2 inhibitor is rofecoxib.
16 . The method of claim 13 , wherein Val-boroPro is administered.
17 . The method of claim 13 , wherein a pharmaceutically acceptable salt of Val-boroPro is administered.
18 . The method of claim 17 , wherein the pharmaceutically acceptable salt of Val-boroPro is Val-boroPro mesylate.