Pyrrolopyrazine kinase inhibitors

1. A compound of Formula I

wherein:

Y is CH(R 1 );

R 1 is H or R 1a ;

R 1a is lower alkyl, lower alkoxy, phenyl, benzyl, heteroaryl, cycloalkyl, heterocycloalkyl, or cycloalkylalkyl, optionally substituted with one or more R 1a′ ;

R 1a′ is halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower hydroxyalkyl, oxo, hydroxy, or —CN;

X is C(R 2 )(R 3 ), N(R 2 ), S(═O) 2 , or O;

each R 2 is independently H or R 2a ;

each R 2a is independently lower alkyl, lower haloalkyl, halogen, lower alkoxy, lower hydroxyalkyl, cyano, cyano lower alkyl, hydroxy, C(═O)R 2a′ or S(═O) 2 R 2a′ ;

each R 2a′ is independently H or lower alkyl;

each X′ is independently halogen, lower alkyl, cyano, hydroxy, lower haloalkyl, lower hydroxyalkyl, heteroaryl, spiroheterocycloalkyl, spirocycloalkyl, lower alkoxy, lower alkylamino, or lower dialkylamino;

or X′ and R 2 come together to form a bicyclic ring system, optionally substituted with one or more R 2′ ;

R 2′ is halogen, lower alkyl, lower alkoxy, hydroxy, lower hydroxyalkyl, lower haloalkyl, lower hydroxyalkylcyano, or —S(O) 2 CH 3 ;

R 3 is H, hydroxy, halogen or lower alkyl;

or R 2 and R 3 come together to form a spirocyclic ring system, optionally substituted with one or more R 2′ ;

q is 0, 1, 2, 3, or 4;

n is 0 or 1;

p is 0 or 1;

Q is H, halogen, hydroxy, cyano or Q′;

Q′ is lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, cycloalkyl, cycloalkyloxy, phenyl, phenyloxy, cycloalkenyl, heterocycloalkyl, or heteroaryl, optionally substituted with one or more Q a ;

Q a is Q b or Q c ;

Q b is halogen, oxo, hydroxy, —CN, —SCH 3 , —S(O) 2 CH 3 , or —S(═O)CH 3 ;

Q c is Q d or Q e′ ;

or two Q a come together to form a bicyclic ring system, optionally substituted with one or more Q b or Q c ;

Q d is —O(Q e ), —S(═O) 2 (Q e ), —C(═O)N(Q e ) 2 , —S(O) 2 (Q e ), —C(═O)(Q e ), —C(═O)O(Q e ), —N(Q e ) 2 ; —N(Q e )C(═O)(Q e ), —N(Q e )C(═O)O(Q e ), or —N(Q e )C(═O)N(Q e ) 2 ;

 each Q e is independently H or Q e′ ;

 each Q e ′ is independently lower alkyl, phenyl, benzyl, lower haloalkyl, lower alkoxy, cycloalkyl, cycloalkyl lower alkyl, cycloalkenyl, heterocycloalkyl, or heteroaryl, optionally substituted with one or more Q f ;

 Q f is Q g or Q h ;

 Q g is halogen, hydroxy, cyano, oxo, or —C(═O)(Q h );

 Q h is lower alkyl, lower haloalkyl, lower alkoxy, amino, phenyl, benzyl, cycloalkyl, heterocycloalkyl, or heteroaryl, optionally substituted with one or more Q i ; and

 Q i is halogen, hydroxy, cyano, lower alkyl, lower haloalkyl, or lower alkoxy;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein Q is cycloalkyl, phenyl or heteroaryl, optionally substituted with one or more Q a .

3. The compound of claim 2 , wherein X is C(R 2 )(R 3 ).

4. The compound of claim 3 , wherein R 2 is lower alkyl, cyano, halogen, lower alkoxy, lower haloalkyl, or hydroxy.

5. The compound of claim 4 , wherein n is 0 and p is 0.

6. The compound of claim 4 , wherein n is 1 and p is 0.

7. The compound of claim 4 , wherein n is 1 and p is 1.

8. The compound of claim 4 , wherein q is 0.

9. The compound of claim 4 wherein R 2 is cyano.

10. The compound of claim 9 , wherein q is 0.

11. The compound of claim 10 , wherein R 1 is lower alkyl, lower alkoxy, cycloalkyl, lower haloalkyl, or lower haloalkyl cycloalkyl.

12. The compound of claim 11 , wherein R 1 is lower alkyl or cycloalkyl.

13. The compound of claim 12 , wherein R 3 is H.

14. The compound of claim 12 , wherein R 3 is lower alkyl.

15. A pharmaceutical composition comprising the compound of claim 1 , admixed with at least one pharmaceutically acceptable carrier, excipient or diluent.

16. A compound selected from the group consisting of:

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(pyrrolidine-1-carbonyl)-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-methyl-1-(pyrrolidine-1-carbonyl)-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-cyclopropyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-methyl-1-(piperidine-1-carbonyl)-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-methyl-1-(morpholine-4-carbonyl)-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-methoxy-pyrrolidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2,2-dimethyl-1-(pyrrolidine-1-carbonyl)-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-hydroxy-pyrrolidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2,2-dimethyl-1-(pyrrolidine-1-carbonyl)-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-pyrrolidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-methyl-2-(3-methyl-pyrrolidin-1-yl)-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-methyl-2-(2-methyl-pyrrolidin-1-yl)-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-2-azetidin-1-y1-1-methyl-2-oxo-ethyl)-amide;

2-Phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-methyl-1-(pyrrolidine-1-carbonyl)-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [2,2,2-trifluoro-1-(pyrrolidine-1-carbonyl)-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3,3-difluoro-pyrrolidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-((S)-3-fluoro-pyrrolidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-((R)-3-fluoro-pyrrolidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-methyl-2-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-methyl-2-oxo-2-(3-trifluoromethyl-pyrrolidin-1-yl)-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-cyclopentyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-cyclopropyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3-cyano-3-methyl-pyrrolidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-((S)-3-cyano-pyrrolidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-((R)-3-cyano-pyrrolidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2,2-dimethyl-1-(piperidine-1-carbonyl)-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3-cyano-azetidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(1-methyl-cyclopropyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3-cyano-3-fluoro-pyrrolidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-cyclohexyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid {(R)-1-[3-(4,5-dihydro-1H-imidazol-2-yl)-3-fluoro-pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl}-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3-cyano-3-methyl-azetidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano- azetidin-1-yl)-1-cyclopentyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3,3-difluoro-pyrrolidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-3-methyl-butyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-4-methyl-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopentyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(S)-2-(4-cyano-piperidin-1-yl)-2-oxo-1-(1-trifluoromethyl-cyclopropyl)-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-2-oxo-1-(1-trifluoromethyl-cyclopropyl)-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-benzyl-2-(4-cyano-piperidin-1-yl)-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-3,3-dimethyl-butyl]-amide;

2-(3,5-Bis-trifluoromethyl-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(3-Pyrrolidin-1-yl-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4,4-difluoro-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3-cyano-azetidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1H-Pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-acetyl-piperazine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2,2-dimethyl-1-(4-trifluoromethyl-piperidine-1-carbonyl)-propyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-((S)-3-cyano-pyrrolidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-((R)-3-cyano-pyrrolidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenyl-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(2,5-Dimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1 -yl)-1 -cyclopropyl-2-oxo-ethyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3-cyano-azetidine-1-carbonyl)-3-methyl-butyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-trifluoromethyl-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-methyl-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(S)-2-(4-cyano-piperidin-1-yl)-2-oxo-1-(1-trifluoromethyl-cyclopropyl)-ethyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-2-oxo-1-(1-trifluoromethyl-cyclopropyl)-ethyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclohexyl-2-oxo-ethyl]-amide;

2-(1-Methyl-1H-imidazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Cyclopropyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-[1-(2,2,2-Trifluoro-ethyl)-1H-pyrazol-4-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-((S)-3-cyano-pyrrolidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-((S)-3-cyano-pyrrolidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-((R)-3-cyano-pyrrolidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-((R)-3-cyano-pyrrolidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-cyclopropyl-2-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-2-oxo-ethyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-cyclopropyl-2-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-cyclopropyl-2-((1S,5R,6R)-6-hydroxymethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-2-oxo-ethyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-cyclopropyl-2-((1S,5R,6R)-6-hydroxymethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-cyclopropyl-2-(1,1-dioxo-1λ 6 -thiomorpholin-4-yl)-2-oxo-ethyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-cyclopropyl-2-(1,1-dioxo-1λ 6 -thiomorpholin-4-yl)-2-oxo-ethyl]-amide;

2-Cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(3,3,3-Trifluoro-propoxy)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopentyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(2,2,2-Trifluoro-ethoxy)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Isopropoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(4-Chloro-1-oxo-1,3-dihydro-isoindol-2-yl)-5H-pyrrolo [2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(7-Chloro-thieno[3,2-b]pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(7-Pyrrolidin-1-yl-thieno[3,2-b]pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-[7-(2,2,2-Trifluoro-ethoxy)-thieno[3,2-b]pyridin-2-yl]-5H-pyrrolo [2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl] -amide;

2-(7-Methoxy-thieno[3,2-b]pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(7-Chloro-thieno[3,2-b]pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(7-Pyrrolidin-1-yl-thieno[3,2-b]pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-[7-(2,2,2-Trifluoro-ethoxy)-thieno[3,2-b]pyridin-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(7-Methoxy-thieno[3,2-b]pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(1,3-Dimethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(S)-1-(4-cyano-piperidine-1-carbonyl)-3,3,3-trifluoro-propyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-3,3,3-trifluoro-propyl]-amide;

2-(1-Cyclopentyl-1H-[1,2,3]triazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(1-Phenyl-1H-[1,2,3]triazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(3-Pyrrolidin-1-yl-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(3-Methylcarbamoyl-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(3-Isopropylcarbamoyl-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-[3-(Cyclopropylmethyl-carbamoyl)-phenyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(4-Cyclopent-1-enyl-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-2-oxo-1-phenyl-ethyl]-amide;

2-Pyridin-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropylmethyl-2-oxo-ethyl]-amide;

2-[1-(4-Fluoro-phenyl)-1H-pyrazol-4-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(4-Trifluoromethyl-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Cyclopropylmethyl-1H-imidazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Cyclopentyl-1H-imidazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Cyclopentyl-1H-imidazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-[1-(2,2,2-Trifluoro-ethyl)-1H-imidazol-4-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-[3-(3,3-Dimethyl-pyrrolidin-1-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(1R,2S)-1-(4-cyano-piperidine-1-carbonyl)-2-methyl-butyl]-amide;

2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-[(1S,5R)-3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(4-Methoxy-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(4-Trifluoromethyl-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1 -carbonyl)-2,2-dimethyl-propyl]-amide;

2-(4-Cyclopropylmethoxy-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(4-Cyclopentyloxy-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(4-Cyclopropylmethoxy-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-[1-(2,5-Difluoro-phenyl)-1H-imidazol-4-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-[1-(2,3,5-Trifluoro-phenyl)-1H-imidazol-4-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4,4-difluoro-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(7,8-dihydro-5H-[1,6]naphthyridine-6-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-2-oxo-1-(tetrahydro-pyran-4-yl)-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(S)-2-(3-cyano-azetidin-1-yl)-2-oxo-1-(tetrahydro-pyran-4-yl)-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(2,3-dihydro-indole-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-cyclopropyl-2-(3,3-difluoro-pyrrolidin-1-yl)-2-oxo-ethyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-methyl-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-3-methyl-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-3-methyl-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3-cyano-3-methyl-azetidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-cyclopropyl-2-(4,4-difluoro-piperidin-1-yl)-2-oxo-ethyl]-amide;

2-(4-tert-Butyl-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-cyclopropyl-2-(4-hydroxy-4-trifluoromethyl-piperidin-1-yl)-2-oxo-ethyl]-amide;

2-(4-Phenyl-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(1-Ethyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-cyclopropyl-2-(3-hydroxy-3-methyl-azetidin-1-yl)-2-oxo-ethyl]-amide;

2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(1R,2R)-1-(4-cyano-piperidine-1-carbonyl)-2-methyl-butyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-cyclopropyl-2-(3,3-difluoro-azetidin-1-yl)-2-oxo-ethyl]-amide;

2-(1-Methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-3-ethyl-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(4-Pyrazol-1-yl-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(4-Pyrrol-1-yl-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(4-Thiophen-2-yl-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(4-Methylcarbamoyl-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide;

2-(2-Chloro-thiazol-5-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-[1-(3,5-Difluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3-cyano-azetidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-[1-(3-Fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(3-cyano-azetidine-1-carbonyl)-2,2-dimethyl-propyl]-amide;

2-(2-Methyl-1-phenyl-1H-imidazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(4-Trifluoromethyl-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-[4-(4-Acetyl-piperazin-1-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-[4-(4-Methyl-piperazin-1-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(4-Morpholin-4-yl-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-(4-Dimethylamino-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide;

2-[2-Methyl-1-(2,2,2-trifluoro-ethyl)-1H-imidazol-4-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide; and

2-Phenyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide.