IP Library › Granted Patent US 12,213,941
Granted Patent B1
US 12,213,941 · App. 18/417,404 · Granted Feb 4, 2025

Adapter for use in a planetary mixer

Inventor: Panagiota Danopoulos (St-Laurent, CA)
Assignee: MEDISCA PHARMACEUTIQUE INC.
A61J1/05A61J3/04A61K9/0034A61K9/06A61K9/107A61K31/045A61K31/135A61K31/137A61K31/192A61K31/195A61K31/196A61K31/197A61K31/351A61K31/4418A61K31/4422A61K31/445A61K31/4458A61K31/565A61K31/57A61K31/7048A61K33/14A61K47/10A61K47/26A61K47/38A61K47/42A61K47/46B01F29/10B01F29/32B01F29/40B01F29/401B01F29/4011B01F29/40221B01F31/00B01F35/2209B01F35/421B65B7/16B01F29/40365
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Quick Facts
Patent No.
US 12,213,941
App. No.
18/417,404
Granted
Feb 4, 2025
Kind
B1
Abstract

A dispensing container and adapter system for use with a planetary mixer is disclosed. The dispensing container has a longitudinal axis and a transverse axis. The dispensing container may include a nozzle and a removable cap to cover the nozzle. The removable cap may have a first width dimension measured along the transverse axis. The dispensing container may include a body having a second width dimension measured along the transverse axis. An adapter may receive the dispensing container. The adapter may include a cavity to receive the removable cap. The cavity may have a cavity width that exceeds the first width dimension. The adapter may also include a recess for receiving a portion of the dispensing container. The recess may extend from the cavity. At least a portion of the recess may have a width dimension smaller than both the first width dimension and the second width dimension.

Claims (49)

1. A mixing system, comprising:

a planetary mixer configured for bladeless mixing;

a container configured to receive mixing ingredients, wherein the container includes a cover having an aperture to permit mixing and including a cap to cover the aperture;

an adapter configured to receive the container, the adapter including:

a circumferential outer wall; and

a central opening configured to receive at least a portion of the container, the adapter configured to secure the container within the planetary mixer, wherein at least a portion of the container is disposed outside the adapter; and

a motor in the planetary mixer configured to subject the container to superimposed movements.

2. The mixing system of claim 1 , wherein the aperture in the cover is configured to receive a blade shaft for connection to a motor of an electric mortar and pestle.

3. The mixing system of claim 2 , wherein the adapter is configured to secure the container such that a central axis of the container aligns with a central axis of the adapter.

4. The mixing system of claim 2 , wherein the mixing ingredients include a composition having an active pharmaceutical ingredient (API) and one or more additional ingredients.

5. The mixing system of claim 2 , wherein the mixer is configured to generate the superimposed movements along two degrees of freedom, wherein the superimposed movements include revolution and rotation movements, wherein the superimposed movements are configured to subject contents within the container to at least one of mixing, de-aerating, melting, or grinding.

6. The mixing system of claim 2 , wherein the container includes a threaded nozzle.

7. The mixing system of claim 2 , wherein the container includes a movable piston.

8. The mixing system of claim 2 , wherein the planetary mixer further includes a protrusion to secure the adapter and the container relative to the planetary mixer.

9. The mixing system of claim 2 , wherein the circumferential outer wall includes a plurality of prongs extending upward.

10. The mixing system of claim 9 , wherein the plurality of prongs abut an outer wall of the container.

11. A mixing system, comprising:

a planetary mixer configured for bladeless mixing;

a container configured to receive mixing ingredients, wherein the container includes a cover having an aperture to permit mixing and including a cap to cover the aperture;

an adapter configured to receive the container, the adapter including:

a central opening configured to receive at least a portion of the container;

a circumferential outer wall, wherein the circumferential outer wall includes a plurality of prongs extending upward to secure the container within the planetary mixer, wherein at least a portion of the container is disposed outside the adapter; and

a motor in the planetary mixer configured to subject the container to superimposed movements.

12. The mixing system of claim 11 , wherein the aperture in the cover is configured to receive a blade shaft for connection to a motor of an electric mortar and pestle.

13. The mixing system of claim 12 , wherein the adapter is configured to secure the container such that a central axis of the container aligns with a central axis of the adapter.

14. The mixing system of claim 12 , wherein the mixing ingredients include a composition having an active pharmaceutical ingredient (API).

15. The mixing system of claim 12 , wherein the mixer is configured to generate the superimposed movements along two degrees of freedom, wherein the superimposed movements include revolution and rotation movements, wherein the superimposed movements are configured to subject contents within the container to at least one of mixing, de-aerating, melting, or grinding.

16. The mixing system of claim 12 , wherein the container includes a threaded nozzle.

17. The mixing system of claim 12 , wherein the container includes a movable piston.

18. The mixing system of claim 12 , wherein the planetary mixer includes a plurality of protrusions secure the adapter and the container relative to the planetary mixer.

19. The mixing system of claim 12 , wherein the plurality of prongs abut an outer wall of the container.

20. A mixing system, comprising:

a container configured to receive mixing ingredients, wherein the container includes:

a cover having an aperture to permit mixing;

a cap to cover the aperture; and

a body;

a planetary mixer configured for bladeless mixing and further configured to secure the container; and

a motor in the planetary mixer configured to generate superimposed movements along two degrees of freedom, wherein the superimposed movements include revolution and rotation movements, wherein the superimposed movements are configured to subject contents within the container to at least one of mixing, de-aerating, melting, or grinding.

21. The mixing system of claim 20 , wherein the aperture in the cover is configured to receive a blade shaft for connection to a motor of an electric mortar and pestle.

22. The mixing system of claim 21 , wherein the container includes a threaded nozzle.

23. The mixing system of claim 21 , wherein the container further includes a piston configured to displace the mixing ingredients, wherein the piston is configured to be pushed from underneath the body.

24. A mixing method, comprising:

placing an aerated composition in a container, wherein the container includes a cover having an aperture to permit mixing and including a cap to cover the aperture;

placing the container in a planetary mixer; and

using the planetary mixer to subject the container to superimposed revolution and rotation movements, wherein the superimposed revolution and rotation movements subject the composition within the container to at least one of mixing, de-aerating, melting, or grinding.

25. The method of claim 24 , further including receiving a blade shaft through the aperture in the cover for connection to a motor of an electric mortar and pestle.

26. The method of claim 25 , wherein the container includes one of a threaded nozzle or a movable piston.

27. The method as defined of claim 25 , wherein the composition includes gelatin.

28. The method of claim 25 , wherein the superimposed revolution and rotation movements are maintained for a period of time of at least 180 seconds.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 19, 2024
From: DANOPOULOS, PANAGIOTA
To: MEDISCA PHARMACEUTIQUE INC.
Reel/Frame 066182/0551 →
Continuity (6)
Continuation 18393974 · Dec 22, 2023
Continuation 17123442 · Dec 16, 2020
Continuation 16372006 · Apr 1, 2019
Continuation 16131986 · Sep 14, 2018
Continuation 15809636 · Nov 10, 2017
Provisional Application 62420426 · Nov 10, 2016
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Medisca, Your Trusted Partner in Compounding; The Maz Mix. Deaerate. Melt. Mill.; Compounding Products, taken from web.archive.org that lists “20170613112836” in the URL (37 pages), https://web.archive.org/web/201706131… [cited by applicant]
Medisca, Your Trusted Partner in Compounding; Promotions, Your Monthly Specials Are Here; View Specials, taken from web.archive.org that lists “20170603222511” in the URL (1 page), https://web.archive.org/web/2017060322… [cited by applicant]
Compounding Pharmacy Products and Services at Medisca; Medisca, Your Trusted Partner in Compounding; Promotions, Your Monthly Specials Are Here; View Specials, taken from web.archive.org that lists “20170603222511” in t… [cited by applicant]
Tian et al.; “Vesicular phospholipid gel-based depot formulations for pharmaceutical proteins: Development and in vitro evaluation”; Journal of Controlled Release 142 (2010); pp. 319-325. [cited by applicant]
Mazerustar, One Single Technology Multiple Capabilities, Apr. 12, 2017, Medisca (8 pages). [cited by applicant]
Medisca, Your Trusted Partner in Compounding: New Base (Gelatin Gum Base), Jun. 25, 2014, (1 page). [cited by applicant]
Hunnius Pharmazeutisches Worterbuch, Walter de Gruyter GmbH, Berlin/Boston, copyright 2014 (6 pages). [cited by applicant]
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Rudolf Voigt, Pharmazeutische Technologie Fur Studium und Beruf, Deutscher Apotheker Verlag Stuttgart, copyright 2010 (8 pages). [cited by applicant]
Claim chart submitted in action for revocation of EP 3538071, dated Jan. 19, 2024 (3 pages). [cited by applicant]
Medisca Response to EPO Communication of Mar. 27, 2023, dated Sep. 22, 2023 (12 pages). [cited by applicant]
Medisca Response to EPO Communication of Dec. 22, 2023, dated Apr. 22, 2024 (24 pages). [cited by applicant]
EPO Summons to attend Oral Proceedings in EP 22192358.4, dated Jun. 10, 2024 (5 pages). [cited by applicant]
Oh! Planetary centrifugal mixers contribute to society, Mar. 2016 (20 pages). [cited by applicant]
Gako International Brochure, copyright 2016 (1 page). [cited by applicant]
Application for cancellation of utility model No. DE 202017007678, Jul. 10, 2024 (3 pages). [cited by applicant]
Submission regarding German utility model DE202017007678.0, dated Apr. 4, 2024 (132 pages). [cited by applicant]
Order of the District Court of Munich regarding EP 3 538 071, dated Apr. 9, 2024 (6 pages). [cited by applicant]
Martin A Erickson III, RPh, “Your Compounding Questions Answered,” Pharmacy Times, vol. 78, Issue 7 (dated Jul. 9, 2012). [cited by applicant]
Lj. Djakovic et al., “Rheological Behavior of Thixotropic Starch and Gelatin Gels,” vol. 42, No. 10, pp. 380-385 (copyright 1990). [cited by applicant]
Shilpa Sanwlani et al., “Hydration of Gelatin Molecules in Glycerol—Water Solvent and Phase Diagram of Gelatin Organogels,” J. Phys. Chem., vol. 115, pp. 7332-7340 (copyright 2011). [cited by applicant]
Fernando A. Osorio et al., “Effects of Concentration, Bloom Degree, and pH on Gelatin Melting and Gelling Temperatures Using Small Amplitude Oscillatory Rheology,” Intl. J. Food Properties, vol. 10, pp. 841-851, (copyri… [cited by applicant]
Susumu Goto et al., “Turbulent mixing in a precessing sphere,” Phys. Fluids, vol. 26, 24 pages, (copyright 2014). [cited by applicant]
Pediatric Compounding—PCCA—Professional Compounding Centers of America website at http://web.archive.org/web/20150926003212/http://www.pccarx.com/what-is-compounding/speciality-compounding/pediatric-compounding, Sep. 26… [cited by applicant]
Flavor Compounding—PCCA—Professional Compounding Centers of America website at http://web.archive.org/web/20151231124835/http://www.pccarx.com:80/what-is-compounding/speciality-compounding/flavor-compounding, Dec. 31, 2… [cited by applicant]
Francesca Milano et al., “Current Trends in Gelatin-Based Drug Delivery Systems,” Pharmaceutics, vol. 15, (copyright 2023) (34 pages). [cited by applicant]
SpeedMixer Technology—Bladeless Mixing | Speedmixer website at http://web.archive.org/web/20160128164145/http://speedmixer.com:80/speedmixer-technology, Jan. 28, 2016 (2 pages). [cited by applicant]
SpeedMixer Containers website at http://web.archive.org/web/20130119075143/http://www.speedmixer.com/containers.php, Jan. 19, 2013 (1 page). [cited by applicant]
Mixer Mill MM400 website at http://web.archive.org/web/20160115200322/http://www.retsch.com:80/products//milling/ball-mills/mixer-mill-mm-400/function-features/, Jan. 15, 2016 (6 pages). [cited by applicant]