Granted Patent
B2
US 12,193,459 · App. 18/465,833 · Granted Jan 14, 2025
Compositions, their use, and methods for their formation
Assignee:
CAMBRIDGE GLYCOSCIENCE LTD
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Abstract
Compositions comprising polysaccharides and oligosaccharides are provided. Methods for the formation of the compositions, including the enzymatic production of the oligosaccharides, and the uses of the compositions in foodstuffs, cosmetics, and nutraceuticals are also provided.
Claims (24)
1. A composition for use in consumer products, comprising at least 50% by dry weight saccharides, wherein the saccharides comprise:
i) less than 50% by dry weight disaccharides, wherein at least 20% by dry weight of the disaccharides comprise cellobiose;
ii) greater than 5% by dry weight trisaccharides;
iii) greater than 2% by dry weight tetrasaccharides; and
iv) unbranched and branched oligosaccharides in a ratio of at least 1:1 by dry weight.
2. The composition of claim 1 , wherein the saccharides further comprise insoluble polysaccharides.
3. The composition of claim 1 , wherein the saccharides comprise from 5-50% by dry weight polysaccharides.
4. The composition of claim 1 , wherein the saccharides comprise cello-oligosaccharides with a DP of 2-6 and xylo-oligosaccharides in a ratio of between 1:9 and 9:1, by dry weight.
5. The composition of claim 3 , wherein the source of the polysaccharides is a biomass.
6. The composition of claim 5 , wherein the biomass comprises corn stover, corn cob, wheat bran, wheat straw, hardwood, softwood, cellulose, chitin, chitosan, xylan, xyloglucan, mixed-linkage glucan, mannan, lignocellulose, or a combination thereof.
7. The composition of claim 1 , wherein the saccharides comprise at least three different types of oligosaccharide.
8. The composition of claim 1 , wherein a solubility of the composition in water is greater w/w when compared to a composition comprising only cello-oligosaccharides with a degree of polymerization from two to six.
9. The composition of claim 1 , wherein the composition comprises less than 5% monosaccharides w/w.
10. The composition of claim 1 , wherein the composition is a hygroscopicity modulator.
11. The composition of claim 1 , wherein the composition has a comparable hygroscopicity to, or greater hygroscopicity than, an identical amount of a control composition wherein the control composition comprises primarily monosaccharides and/or disaccharides.
12. The composition of claim 1 wherein the composition is included at 1% w/w or more of a consumer product.
13. The composition of claim 12 , wherein the consumer product is a cosmetic product.
14. The composition of claim 13 , wherein the cosmetic product is a mascara, a foundation, a lip gloss, an eyeshadow, an eyeliner, a primer, a lipstick blush, a nail polish, a bronzer, a makeup, a shampoo, a conditioner, a styling mousse, a styling gel, a hairspray, a hair dye, a hair wax, a moisturizer, a exfoliant, a sun cream, a cleanser, a toothpaste, a cream, a lotion, an ointment, or a face mask.
15. The composition of claim 12 , wherein the consumer product is a nutraceutical product.
16. The composition of claim 15 , wherein the nutraceutical product is a probiotic formulation or a prebiotic formulation.
17. The composition of claim 12 , wherein the consumer product is a binding product.
18. The composition of claim 12 , wherein consumer product comprises 1-30% by dry weight of polysaccharides.
19. The composition of claim 12 , wherein the the composition comprises a phenolic compound, a portion of lignin, and/or a product of lignin breakdown.
20. The composition of claim 1 , wherein the composition is a raw material for processing to a further composition.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 18, 2026
From: CAMBRIDGE GLYCOSCIENCE LTD
To: PFEIFER & LANGEN UK LIMITED
Reel/Frame 074508/0148 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 3, 2024
From: SIMMONS, THOMAS J.
To: CAMBRIDGE GLYCOSCIENCE LTD
Reel/Frame 067906/0020 →
Continuity (5)
Continuation
PCTEP2019072026
· Aug 16, 2019
Provisional Application
62764660
· Aug 15, 2018
References Cited (345)
US 4927646A
· Jenner et al.
· 1990
[cited by applicant]
US 6667066B2
· Labeille et al.
· 2003
[cited by applicant]
US 7033626B2
· Spendler et al.
· 2006
[cited by applicant]
US 7151079B2
· Fack et al.
· 2006
[cited by applicant]
US 7378103B2
· Kanji et al.
· 2008
[cited by applicant]
US 7598069B2
· Felby et al.
· 2009
[cited by applicant]
US 7754456B2
· Penttila et al.
· 2010
[cited by applicant]
US 7993463B2
· Griffin et al.
· 2011
[cited by applicant]
US 7993890B2
· Soerensen et al.
· 2011
[cited by applicant]
US 8057840B2
· Harrison et al.
· 2011
[cited by applicant]
US 8202842B2
· Sinclair et al.
· 2012
[cited by applicant]
US 8247200B2
· Foody et al.
· 2012
[cited by applicant]
US 8663952B2
· He et al.
· 2014
[cited by applicant]
US 8679794B2
· Muniglia et al.
· 2014
[cited by applicant]
US 8709763B2
· Lali et al.
· 2014
[cited by applicant]
US 8894771B2
· Floyd et al.
· 2014
[cited by applicant]
US 8927038B2
· Broekaert et al.
· 2015
[cited by applicant]
US 8956846B2
· Ben Chaabane et al.
· 2015
[cited by applicant]
US 9062328B2
· Medoff
· 2015
[cited by applicant]
US 9090916B2
· Casanave et al.
· 2015
[cited by applicant]
US 9113652B2
· Pilling et al.
· 2015
[cited by applicant]
US 9150895B2
· Kurihara et al.
· 2015
[cited by applicant]
US 9410216B2
· Eyal et al.
· 2016
[cited by applicant]
US 9458482B2
· Bals et al.
· 2016
[cited by applicant]
US 9580729B2
· Noda et al.
· 2017
[cited by applicant]
US 9605291B2
· Yamada et al.
· 2017
[cited by applicant]
US 9663836B2
· Jansen et al.
· 2017
[cited by applicant]
US 9670516B2
· Minamino et al.
· 2017
[cited by applicant]
US 9783860B2
· Floyd et al.
· 2017
[cited by applicant]
US 9797021B2
· Floyd et al.
· 2017
[cited by applicant]
US 9920309B2
· Reisinger et al.
· 2018
[cited by applicant]
US 9920346B2
· Funada et al.
· 2018
[cited by applicant]
US 9955707B2
· Delbaere
· 2018
[cited by applicant]
US 9963725B2
· Lali et al.
· 2018
[cited by applicant]
US 9963728B2
· Minamino et al.
· 2018
[cited by applicant]
US 9982280B2
· Noordam et al.
· 2018
[cited by applicant]
US 9988657B2
· Nagy et al.
· 2018
[cited by applicant]
US 20030091691A1
· Olsen et al.
· 2003
[cited by applicant]
US 20040258829A1
· Zheng et al.
· 2004
[cited by applicant]
US 20080102163A1
· O'Toole et al.
· 2008
[cited by applicant]
US 20090042266A1
· Vehmaanpera et al.
· 2009
[cited by applicant]
US 20090062232A1
· Fujikawa et al.
· 2009
[cited by applicant]
US 20110171710A1
· Yu et al.
· 2011
[cited by applicant]
US 20120035127A1
· Goffin et al.
· 2012
[cited by applicant]
US 20120231147A1
· Srinivasan et al.
· 2012
[cited by applicant]
US 20130164420A1
· Catani et al.
· 2013
[cited by applicant]
US 20140030381A1
· Markysyan
· 2014
[cited by applicant]
US 20150065454A1
· Dupasquier et al.
· 2015
[cited by applicant]
US 20160235098A1
· Cox
· 2016
[cited by applicant]
US 20170114371A1
· Pedersen et al.
· 2017
[cited by applicant]
US 20170295805A1
· Abu-Hardan et al.
· 2017
[cited by applicant]
US 20170303548A1
· Krogh et al.
· 2017
[cited by applicant]
US 20170303550A1
· Abu-Hardan et al.
· 2017
[cited by applicant]
US 20180134741A1
· Falck
· 2018
[cited by applicant]
US 20180362669A1
· Fujita et al.
· 2018
[cited by applicant]
US 20190029272A1
· Niemann
· 2019
[cited by applicant]
US 20190153555A1
· Eyal et al.
· 2019
[cited by applicant]
US 20190281874A1
· Davidek et al.
· 2019
[cited by applicant]
US 20200071736A1
· Hammerer et al.
· 2020
[cited by applicant]
US 20200123577A1
· De Laat et al.
· 2020
[cited by applicant]
US 20200299791A1
· McKay et al.
· 2020
[cited by applicant]
US 20200308212A1
· Falck
· 2020
[cited by applicant]
US 20210120855A1
· Park et al.
· 2021
[cited by applicant]
US 20210177021A1
· Simmons
· 2021
[cited by applicant]
US 20210207321A1
· Loureiro et al.
· 2021
[cited by applicant]
US 20210253977A1
· Huang et al.
· 2021
[cited by applicant]
US 20210347694A1
· Havenith et al.
· 2021
[cited by applicant]
US 20220017766A1
· Kalb
· 2022
[cited by applicant]
US 20220132896A1
· Kannar et al.
· 2022
[cited by applicant]
US 20220273013A1
· Simmons et al.
· 2022
[cited by applicant]
US 20220338516A1
· Simmons et al.
· 2022
[cited by applicant]
US 20240114940A1
· Simmons et al.
· 2024
[cited by applicant]
CA 2831543A1
· 2012
[cited by applicant]
CN 1482868A
· 2004
[cited by applicant]
CN 101272794A
· 2008
[cited by applicant]
CN 101677603A
· 2010
[cited by applicant]
CN 101899488A
· 2010
[cited by applicant]
CN 102084055A
· 2011
[cited by applicant]
CN 102925516A
· 2013
[cited by applicant]
CN 103053903A
· 2013
[cited by applicant]
CN 105722407A
· 2016
[cited by applicant]
CN 106367449A
· 2017
[cited by applicant]
CN 107746866A
· 2018
[cited by applicant]
CN 108135222A
· 2018
[cited by applicant]
CN 108157664A
· 2018
[cited by applicant]
CN 108588144A
· 2018
[cited by applicant]
EP 1228098B1
· 2006
[cited by applicant]
EP 1466926B1
· 2007
[cited by applicant]
EP 1751296B1
· 2009
[cited by applicant]
EP 1699974B1
· 2009
[cited by applicant]
EP 2256208A1
· 2010
[cited by applicant]
EP 2235195B1
· 2011
[cited by applicant]
EP 2076271B1
· 2011
[cited by applicant]
EP 1871400B1
· 2011
[cited by applicant]
EP 1811038B1
· 2012
[cited by applicant]
EP 2225387B1
· 2012
[cited by applicant]
EP 2265127B1
· 2013
[cited by applicant]
EP 2665823A1
· 2013
[cited by applicant]
EP 2427565B1
· 2014
[cited by applicant]
EP 1977652B1
· 2015
[cited by applicant]
EP 3010352A1
· 2016
[cited by applicant]
EP 3013155A1
· 2016
[cited by applicant]
EP 3037005A1
· 2016
[cited by applicant]
EP 1706477B1
· 2016
[cited by applicant]
EP 2313514B1
· 2016
[cited by applicant]
EP 2784156B1
· 2017
[cited by applicant]
EP 2817374B1
· 2017
[cited by applicant]
EP 2996492B1
· 2017
[cited by applicant]
EP 3041941B1
· 2017
[cited by applicant]
EP 2548966B1
· 2018
[cited by applicant]
EP 2548965B1
· 2018
[cited by applicant]
EP 3374315A1
· 2018
[cited by applicant]
EP 2117322B1
· 2018
[cited by applicant]
EP 3177728B1
· 2018
[cited by applicant]
EP 3177729B1
· 2018
[cited by applicant]
EP 3182830B1
· 2018
[cited by applicant]
EP 3190189B1
· 2018
[cited by applicant]
EP 3415632A1
· 2018
[cited by applicant]
EP 3438272A1
· 2019
[cited by applicant]
EP 2734633B1
· 2019
[cited by applicant]
EP 2917359B1
· 2019
[cited by applicant]
EP 3511418A1
· 2019
[cited by applicant]
EP 3530743A1
· 2019
[cited by applicant]
EP 3541870A1
· 2019
[cited by applicant]
EP 2917355B1
· 2019
[cited by applicant]
EP 3088530B1
· 2020
[cited by applicant]
EP 3511418B1
· 2020
[cited by applicant]
EP 3737769A1
· 2020
[cited by applicant]
EP 3010352B1
· 2020
[cited by applicant]
EP 3784045A1
· 2021
[cited by applicant]
EP 3815540A1
· 2021
[cited by applicant]
EP 3960772A1
· 2022
[cited by applicant]
EP 3981379A2
· 2022
[cited by applicant]
EP 3993644A1
· 2022
[cited by applicant]
EP 3438272B1
· 2022
[cited by applicant]
JP S5840066A
· 1983
[cited by applicant]
JP H10117800A
· 1998
[cited by applicant]
JP 2003334000A
· 2003
[cited by applicant]
JP 2004520318A
· 2004
[cited by applicant]
JP 2006087319A
· 2006
[cited by applicant]
JP 2007049914A
· 2007
[cited by applicant]
JP 2008120789A
· 2008
[cited by applicant]
JP 2009089626A
· 2009
[cited by applicant]
JP 2009125064A
· 2009
[cited by applicant]
JP 2010527613A
· 2010
[cited by applicant]
JP 2010200720A
· 2010
[cited by applicant]
JP 2010215556A
· 2010
[cited by applicant]
JP 2010226995A
· 2010
[cited by applicant]
JP 2011103874A
· 2011
[cited by applicant]
JP 2012527886A
· 2012
[cited by applicant]
JP 2014140347A
· 2014
[cited by applicant]
JP 2017502701A
· 2017
[cited by applicant]
KR 20190133438A
· 2019
[cited by applicant]
WO WO2012107204A1
· 2012
[cited by applicant]
WO WO2012133495A1
· 2012
[cited by applicant]
WO WO2012141256A1
· 2012
[cited by applicant]
WO WO2013016115A1
· 2013
[cited by applicant]
WO WO2013096603A2
· 2013
[cited by applicant]
WO WO2013159005A2
· 2013
[cited by applicant]
WO WO2014170498A1
· 2014
[cited by applicant]
WO WO2015107413A1
· 2015
[cited by applicant]
WO WO2017057718A1
· 2017
[cited by applicant]
WO WO2017104687A1
· 2017
[cited by applicant]
WO WO2017107527A1
· 2017
[cited by applicant]
WO WO2018106656A1
· 2018
[cited by applicant]
WO WO2019010336A1
· 2019
[cited by applicant]
WO WO2019055717A1
· 2019
[cited by applicant]
WO WO2019102218A2
· 2019
[cited by applicant]
WO WO2019138024A1
· 2019
[cited by applicant]
WO WO2019162416A1
· 2019
[cited by applicant]
WO WO2019227525A1
· 2019
[cited by applicant]
WO WO2019229228A1
· 2019
[cited by applicant]
WO WO2019239366A1
· 2019
[cited by applicant]
WO WO2020009964A1
· 2020
[cited by applicant]
WO WO2020035599A1
· 2020
[cited by applicant]
WO WO2020097458A1
· 2020
[cited by applicant]
WO WO2021032647A1
· 2021
[cited by applicant]
WO WO2021074271A1
· 2021
[cited by applicant]
WO WO2021074316A1
· 2021
[cited by applicant]
WO WO2021116437A2
· 2021
[cited by applicant]
WO WO2021116437A3
· 2021
[cited by applicant]
WO WO2021140225A1
· 2021
[cited by applicant]
WO WO2021243151A1
· 2021
[cited by applicant]
WO WO2021257921A1
· 2021
[cited by applicant]
WO WO2022034078A1
· 2022
[cited by applicant]
WO WO2022060726A1
· 2022
[cited by applicant]
WO WO2022067131A1
· 2022
[cited by applicant]
WO WO2022069084A1
· 2022
[cited by applicant]
WO WO2022073646A1
· 2022
[cited by applicant]
Aachary et al. Xylooligosaccharides (XOS) as an Emerging Prebiotic: Microbial Synthesis, Utilization, Structural Characterization, Bioactive Properties, and Applications. Comprehensive Reviews in Food Science and Food S…
[cited by applicant]
Basholli-Salihu et al. The Use of Cellobiose and Fructooligosaccharide on Growth and Stability of Bifidobacterium infantis in Fermented Milk. Food and Nutrition Sciences, 2013, 4, 1301-1306. Published Online Dec. 2013. …
[cited by applicant]
Beldman et al. Application of cellulase and pectinase from fungal origin for the liquefaction and saccharification of biomass. Enzyme and Microbial Technology, vol. 6, Issue 11, pp. 503-507 (Nov. 1984). DOI: https://doi…
[cited by applicant]
Bhale et al. Enzymatic activity of
[cited by applicant]
Brijwani et al. Production of a cellulolytic enzyme system in mixed-culture solid-state fermentation of soybean hulls supplemented with wheat bran. Process Biochemistry, vol. 45, No. 1, 120-128 (2010).
[cited by applicant]
Chen et al. Characterization of a novel xylanase from Aspergillus flavus with the unique properties in production of xylooligosaccharides. J Basic Microbiol. Apr. 2019;59(4):351-358. doi: 10.1002/jobm.201800545. Epub Fe…
[cited by applicant]
Chica, et al. Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design. Curr Opin Biotechnol. Aug. 2005;16(4):378-84.
[cited by applicant]
Dallabernardina et al. Mixed-Linkage Glucan Oligosaccharides Produced by Automated Glycan Assembly Serve as Tools To Determine the Substrate Specificity of Lichenase. Chemistry. Mar. 2, 2017;23(13):3191-3196. doi: 10.10…
[cited by applicant]
Danneels et al. A quantitative indicator diagram for lytic polysaccharide monooxygenases reveals the role of aromatic surface residues in HjLPMO9A regioselectivity. PLoS One. 2017; 12(5): e0178446. Published online May …
[cited by applicant]
De La Fuente et al. Development of a robust method for the quantitative determination of disaccharides in honey by gas chromatography. J Chromatogr A, 1135 (2006) 212-218.
[cited by applicant]
Dos Santos et al. Structural basis for xyloglucan specificity and α-d-Xylp(1 → 6)-D-Glcp recognition at the −1 subsite within the GH5 family. Biochemistry. Mar. 17, 2015;54(10):1930-42. doi: 10.1021/acs.biochem.5b00011.…
[cited by applicant]
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2018). Safety of xylo-oligosaccharides (XOS) as a novel food pursuant to Regulation (EU) 2015/2283: (Scientific Opinion). E F S A Journal, 16(7), [5361]. D…
[cited by applicant]
El Khoury et al. Beta Glucan: Health Benefits in Obesity and Metabolic Syndrome. J Nutr Metab. 2012; 2012: 851362. Published online Dec. 11, 2011. doi: 10.1155/2012/851362. 28 pages.
[cited by applicant]
EP18157957.4 Extended European Search Report dated Jul. 13, 2018.
[cited by applicant]
Falck et al. Arabinoxylanase from glycoside hydrolase family 5 is a selective enzyme for production of specific arabinoxylooligosaccharides. Food Chem. Mar. 1, 2018;242:579-584. doi: 10.1016/j.foodchem.2017.09.048. Epub…
[cited by applicant]
Fanuel et al. The Podospora anserina lytic polysaccharide monooxygenase PaLPMO9H catalyzes oxidative cleavage of diverse plant cell wall matrix glycans. Biotechnol Biofuels. 2017; 10: 63. Published online Mar. 11, 2017.…
[cited by applicant]
Gorton. Spare the sugar. bakingbusiness.com. Mar. 31, 2013. Retrieved Sep. 16, 2020 from: https://www.bakingbusiness.com/articles/34774-spare-the-sugar. 8 pages.
[cited by applicant]
Goubet et al. Polysaccharide analysis using carbohydrate gel electrophoresis: a method to study plant cell wall polysaccharides and polysaccharide hydrolases. Anal Biochem. Jan. 1, 2002;300(1):53-68.
[cited by applicant]
Gras Notification—Claim of GRAS Status (Revised May 21, 2010), Claim of Exemption from the Requirement for Premarket Approval Requirements Pursuant to Proposed 21 CFR § 170.36(c)(1), pp. 000007 and 000015. EAS Consultin…
[cited by applicant]
Greek Yogurt with Honey Base, Database Accession No. 4046243, Database GNPD online (Jun. 6, 2016). Mintel. 4 pages.
[cited by applicant]
Green et al. Industrial Fungal Enzymes: An Occupational Allergen Perspective. Journal of Allergy, vol. 2011, Article ID 682574, 11 pages.
[cited by applicant]
Gupta et al. Xylooligosaccharide—A Valuable Material from Waste to Taste: A Review. J Environ Res Develop, vol. 10, No. 3, pp. 555-563 (Jan.-Mar. 2016).
[cited by applicant]
Hakala et al. Enzyme-aided alkaline extraction of oligosaccharides and polymeric xylan from hardwood kraft pulp. Carbohydr Polym. Mar. 1, 2013;93(1):102-8. doi: 10.1016/j.carbpol.2012.05.013. Epub May 11, 2012.
[cited by applicant]
Hang et al. Enzymatic Production of Soluble Sugars from Corn Husks. LWT—Food Science and Technology, vol. 32, Issue 4, pp. 208-210 (Jun. 1999). DOI: https://doi.org/10.1006/fstl.1998.0530.
[cited by applicant]
Jayapal et al. Value addition to sugarcane bagasse: Xylan extraction and its process optimization for xylooligosaccharides production. Industrial Crops and Products, vol. 42, pp. 14-24 (2013).
[cited by applicant]
Jousse et al. Simplified Kinetic Scheme of Flavor Formation by the Maillard Reaction. Journal of Food Science, vol. 67, No. 7, pp. 2534-2542 (2002).
[cited by applicant]
Karadeniz et al. Sugar composition of apple juices. European Food Research and Technology, vol. 215, pp. 145-148 (2002).
[cited by applicant]
Kracher et al. Active-site copper reduction promotes substrate binding of fungal lytic polysaccharide monooxygenase and reduces stability. J Biol Chem. Feb. 2, 2018; 293(5): 1676-1687. Published online Dec. 19, 2017. do…
[cited by applicant]
Kuhad et al. Microbial Cellulases and Their Industrial Applications. Enzyme Res. 2011; 2011: 280696. Published online Sep. 7, 2011. doi: 10.4061/2011/280696.
[cited by applicant]
Lecumberri et al. A diet rich in dietary fiber from cocoa improves lipid profile and reduces malondialdehyde in hypercholesterolemic rats. Nutrition. Apr. 2007;23(4):332-41. doi: 10.1016/j.nut.2007.01.013. Epub Mar. 23,…
[cited by applicant]
Linares-Pastén et al. Structural Considerations on the Use of Endo-Xylanases for the Production of prebiotic Xylooligosaccharides from Biomass. Curr Protein Pept Sci. Jan. 2018;19(1): 48-67. Published online Jan. 2018. …
[cited by applicant]
Loose et al. Activation of bacterial lytic polysaccharide monooxygenases with cellobiose dehydrogenase. Protein Sci. Dec. 2016; 25(12): 2175-2186. Published online Sep. 26, 2016. doi: 10.1002/pro.3043.
[cited by applicant]
Lu et al. Extraction and modification of hemicellulose from lignocellulosic biomass: A review. Green Processing and Synthesis 2021; 10: 779-804.
[cited by applicant]
Maehara et al. GH30 Glucuronoxylan-Specific Xylanase from
[cited by applicant]
Maple et al. Detailed Tautomeric Equilibrium of Aqueous D-Glucose. Observation of Six Tautomers by Ultrahigh Resolution Carbon-13 NMR. J Am Chem Soc 1987, 109, 3168-3169.
[cited by applicant]
Mathew et al. Xylo- and arabinoxylooligosaccharides from wheat bran by endoxylanases, utilisation by probiotic bacteria, and structural studies of the enzymes. Appl Microbiol Biotechnol. Apr. 2018;102(7):3105-3120. doi:…
[cited by applicant]
Meier et al. Oxygen Activation by Cu LPMOs in Recalcitrant Carbohydrate Polysaccharide Conversion to Monomer Sugars. Chem Rev. Mar. 14, 2018; 118(5): 2593-2635. Published online Nov. 20, 2017. doi: 10.1021/acs.chemrev.7…
[cited by applicant]
Motta et al. Chapter 10: “A Review of Xylanase Production by the Fermentation of Xylan: Classification, Characterization and Applications,” pp. 251-275. In Sustainable Degradation of Lignocellulosic Biomass, Chandel and…
[cited by applicant]
Nordberg Karlsson et al. Endo-xylanases as tools for production of substituted xylooligosaccharides with prebiotic properties. Appl Microbiol Biotechnol. 2018; 102(21): 9081-9088. Published online Sep. 8, 2018. doi: 10.…
[cited by applicant]
Park et al. Effect of fructo-oligosaccharide and isomalto-oligosaccharide addition on baking quality of frozen dough. Food Chem. Dec. 15, 2016;213:157-162. doi: 10.1016/j.foodchem.2016.06.067. Epub Jun. 21, 2016.
[cited by applicant]
PCT/EP2019/054380 International Search Report and Written Opinion dated Jun. 27, 2019.
[cited by applicant]
PCT/EP2019/072026 International Search Report and Written Opinion dated Dec. 2, 2019.
[cited by applicant]
PCT/EP2020/072929 International Search Report and Written Opinion dated Dec. 8, 2020.
[cited by applicant]
PCT/EP2020/085810 International Search Report and Written Opinion dated Jun. 9, 2021.
[cited by applicant]
PCT/EP2021/050311 International Search Report and Written Opinion dated May 3, 2021.
[cited by applicant]
Qi et al. Application of ultrafiltration and nanofiltration for recycling cellulase and concentrating glucose from enzymatic hydrolyzate of steam exploded wheat straw. Bioresour Technol. Jan. 2012;104:466-72. doi: 10.10…
[cited by applicant]
Qing et al. “Chapter 19: Xylooligosaccharides Production, Quantification, and Characterization in Context of Lignocellulosic Biomass Pretreatment,” pp. 391-415. In Aqueous Pretreatment of Plant Biomass forBiological and…
[cited by applicant]
Réhault-Godbert et al. The Golden Egg: Nutritional Value, Bioactivities, and Emerging Benefits for Human Health. Nutrients 11, 684 (Mar. 22, 2019). 26 pages.
[cited by applicant]
Schmiele et al. Mixolab™ for rheological evaluation of wheat flour partially replaced by soy protein hydrolysate and fructooligosaccharides for bread production. LWT—Food Science and Technology, vol. 76, Part B, pp. 259…
[cited by applicant]
Senevirathne et al. Effect of Mixed Microbial Culture Treatment on the Nutritive Value of Coffee, Green Tea and Oolong Tea Residues and the Effect of the Fermented Residues on in Vitro Rumen Fermentation. APCBEE Procedi…
[cited by applicant]
Short-Chain Fructooligosaccharides: Handling/Processing. Technical Evaluation Report. U.S. Department of Agriculture (USDA) Agricultural Marketing Service (AMS). Aug. 11, 2006. Retrieved Sep. 16, 2020 from URL: https://…
[cited by applicant]
Simmons et al. An unexpectedly lichenase-stable hexasaccharide from cereal, horsetail and lichen mixed-linkage β-glucans (MLGs): implications for MLG subunit distribution. Phytochemistry. Nov. 2013;95:322-32. doi: 10.10…
[cited by applicant]
Simmons et al. Bonds broken and formed during the mixed-linkage glucan : xyloglucan endotransglucosylase reaction catalysed by Equisetum hetero-trans-β-glucanase. Biochem J. Apr. 1, 2017; 474(7): 1055-1070. Published on…
[cited by applicant]
Simmons et al. Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates. Nat Commun. 2017; 8: 1064. Published online Oct. 20, 2017. doi: 10.1038/s41467-017-012…
[cited by applicant]
Singh et al. Protein Engineering Approaches in the Post-Genomic Era. Curr Protein Pept Sci. 18: 1-11 (2017).
[cited by applicant]
Sun et al. Hydrolysis of lignocellulosic materials for ethanol production: a review. Bioresour Technol. May 2002;83(1):1-11. doi: 10.1016/s0960-8524(01)00212-7.
[cited by applicant]
Tanaka et al. Creation of cellobiose and xylooligosaccharides-coutilizing
[cited by applicant]
U.S. Appl. No. 16/844,960 Notice of Allowance dated Feb. 3, 2021.
[cited by applicant]
U.S. Appl. No. 16/844,960 Office Action dated Sep. 22, 2020.
[cited by applicant]
U.S. Appl. No. 16/999,483 Office Action dated Jul. 28, 2023.
[cited by applicant]
U.S. Appl. No. 17/033,321 Notice of Allowance dated Oct. 6, 2021.
[cited by applicant]
U.S. Appl. No. 17/033,321 Office Action dated Aug. 2, 2021.
[cited by applicant]
U.S. Appl. No. 17/033,321 Office Action dated Jan. 11, 2021.
[cited by applicant]
U.S. Appl. No. 17/083,121 Notice of Allowance dated Aug. 23, 2021.
[cited by applicant]
U.S. Appl. No. 17/083,121 Notice of Allowance dated Dec. 8, 2021.
[cited by applicant]
U.S. Appl. No. 17/083,121 Office Action dated May 14, 2021.
[cited by applicant]
U.S. Appl. No. 17/571,199 Notice of Allowance dated Feb. 7, 2023.
[cited by applicant]
U.S. Appl. No. 17/571,199 Notice of Allowance dated Oct. 14, 2022.
[cited by applicant]
U.S. Appl. No. 17/571,199 Office Action dated Apr. 28, 2022.
[cited by applicant]
U.S. Appl. No. 17/571,199 Office Action dated Sep. 7, 2022.
[cited by applicant]
U.S. Appl. No. 17/837,868 Office Action dated Feb. 8, 2023.
[cited by applicant]
U.S. Appl. No. 17/837,868 Office Action dated Jun. 5, 2023.
[cited by applicant]
U.S. Appl. No. 17/837,868 Office Action dated Oct. 5, 2022.
[cited by applicant]
U.S. Appl. No. 17/846,188 Notice of Allowance dated Aug. 14, 2023.
[cited by applicant]
U.S. Appl. No. 17/846,188 Notice of Allowance dated Aug. 24, 2023.
[cited by applicant]
U.S. Appl. No. 17/846,188 Notice of Allowance dated Jun. 20, 2023.
[cited by applicant]
U.S. Appl. No. 17/846,188 Notice of Allowance dated May 30, 2023.
[cited by applicant]
U.S. Appl. No. 17/846,188 Office Action dated Mar. 21, 2023.
[cited by applicant]
U.S. Appl. No. 17/846,188 Office Action dated Nov. 28, 2022.
[cited by applicant]
Villares et al. Lytic polysaccharide monooxygenases disrupt the cellulose fibers structure. Sci Rep. 2017; 7: 40262. Published online Jan. 10, 2017. doi: 10.1038/srep40262.
[cited by applicant]
Wang et al. Relative fermentation of oligosaccharides from human milk and plants by gut microbes. European Food Research and Technology, vol. 243, pp. 133-146 (2017). Published online Jun. 20, 2016.
[cited by applicant]
Watanabe, Eiichi. Membrane Separation in Cellulose Saccharification and Mixed Enzyme Culture Liquid Recycling. [Medicine and Biology, vol. No. 119, Issue No. 3, Sep. 10, 1989]. 7 pages.
[cited by applicant]
Xiao et al. Application of Xylo-oligosaccharide in modifying human intestinal function. African Journal of Microbiology Research 6(9):2116-2119 (Mar. 9, 2012).
[cited by applicant]
Zhang et al. Hemicellulose isolation, characterization, and the production of xylo-oligosaccharides from the wastewater of a viscose fiber mill. Carbohydr Polym. May 5, 2016;141:238-43. doi: 10.1016/j.carbpol.2016.01.02…
[cited by applicant]
Zivkovic et al. Bovine Milk as a Source of Functional Oligosaccharides for Improving Human Health. Adv Nutr 2:284-289 (2011).
[cited by applicant]
Co-pending U.S. Appl. No. 17/865,142, inventors Bartosiak-Jentys; Jeremy et al., filed on Jul. 14, 2022.
[cited by applicant]
Machine translation of JP2008-120789, Ichiro et al., publication date: May 29, 2008. pp. 1-31.
[cited by applicant]
Machine translation of JP2009-089626, Mitsuyo et al., publication date: Apr. 30, 2009. pp. 1-26.
[cited by applicant]
Translation of JP 2008-120789, published May 29, 2008. 19 pages.
[cited by applicant]
U.S. Appl. No. 16/999,483 Office Action dated Dec. 12, 2023.
[cited by applicant]
U.S. Appl. No. 17/229,628 Notice of Allowance dated Jun. 20, 2023.
[cited by applicant]
U.S. Appl. No. 17/229,628 Notice of Allowance dated Sep. 15, 2023.
[cited by applicant]
U.S. Appl. No. 17/229,628 Office Action dated Apr. 5, 2023.
[cited by applicant]
U.S. Appl. No. 17/229,628 Office Action dated Nov. 10, 2022.
[cited by applicant]
U.S. Appl. No. 17/837,868 Notice of Allowance dated Dec. 4, 2023.
[cited by applicant]
U.S. Appl. No. 17/837,868 Notice of Allowance dated Oct. 20, 2023.
[cited by applicant]
U.S. Appl. No. 17/837,868 Notice of Allowance dated Sep. 27, 2023.
[cited by applicant]
Co-pending U.S. Appl. No. 18/486,738, inventors Simmons; Thomas J. et al., filed on Oct. 13, 2023.
[cited by applicant]
Tosh, Susan, et al., Structural characteristics and rheological properties of partially hydrolyzed oat b-glucan: the effects of molecular weight and hydrolysis method. Carbohydrate Polymers 55:425-436 (2004).
[cited by applicant]
U.S. Appl. No. 16/999,483 Office Action dated Apr. 23, 2024.
[cited by applicant]
Ying, Danyang, et al., Enhanced survival of spray-dried microencapsulated Lactobacillus rhamnosus GG in the presence of glucose. Journal of Food Engineering 109:597-602 (2012). Available online Oct. 18, 2011.
[cited by applicant]