IP Library › Granted Patent US 12,251,411
Granted Patent B2
US 12,251,411 · App. 18/467,953 · Granted Mar 18, 2025

Methods of treating endometrial cancer using hemp extract

Inventors: Alexandra M. Capano (Philadelphia, PA); Pradeep Singh Tanwar (Fletcher, AU); Alex Nance (Georgetown, KY)
Assignees: Ecofibre USA Inc.; The University of Newcastle
A61K36/185A61K31/01A61K31/015A61K31/045A61K31/05A61K31/198A61K31/216A61K31/282A61K31/337A61K31/352A61K31/355A61K31/4745A61K31/513A61K31/519A61K31/5545A61K31/675A61K31/704A61K31/7048A61K31/7068A61K33/243A61K39/3955A61P35/00
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Quick Facts
Patent No.
US 12,251,411
App. No.
18/467,953
Granted
Mar 18, 2025
Kind
B2
Abstract

A method for treating endometrial cancer comprising: administering to a patient a cannabis extract (CE) wherein the cannabis extract comprises cannabidiol (CBD) at between 50% and 99% by weight of the CE.

Claims (29)

1. A method for treating endometrial cancer comprising:

a. administering to a patient an effective amount of a composition comprising a cannabis extract (CE) wherein the CE comprises between 50% and 99.9% cannabidiol (CBD) and wherein said composition has a pH of between 3.5 and 6;

b. wherein the CE is administered via an intravaginal form; and

c. wherein the effective amount of the CE comprises between 10 mg and 4,250 mg of CBD per day.

2. The method of claim 1 wherein the endometrial cancer is a grade 1, grade 2, grade 3, or chemoresistant endometrial cancer.

3. The method of claim 1 wherein the CE comprises cannabidiolic acid (CBDA) at a concentration of between 0.1% and 10%.

4. The method of claim 1 wherein the composition further comprises a carrier and wherein the CE is 50% to 99% of a total weight of the composition.

5. The method of claim 1 wherein the CE is a broad spectrum hemp extract (BSHE) or a full spectrum hemp extract (FSHE) and wherein each of the BSHE or FSHE comprises between 60% and 99% by weight of CBD and at least one other cannabinoid at a concentration of 0.1% to 10% by weight wherein the at least one other cannabinoid is selected from the group consisting of:

Δ-9-tetrahydrocannabinol (Δ 9 -THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), Δ-8-tetrahydrocannabinol (Δ 8 -THC), cannabichromene (CBC), cannabichromene acid (CBCA), cannabigerol (CBG), cannabigerol acid (CBGA), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabicyclol (CBL), and combinations thereof.

6. The method of claim 1 wherein the CE comprises cannabidiol (CBD) at a concentration of between 60% and 99% and at least one other cannabinoid at a concentration of 0.1% to 10% wherein the at least one other cannabinoid is selected from the group consisting of: Δ-9-tetrahydrocannabinol (Δ 9 -THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), Δ-8-tetrahydrocannabinol (Δ 8 -THC), cannabichromene (CBC), cannabichromene acid (CBCA), cannabigerol (CBG), cannabigerol acid (CBGA), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabicyclol (CBL), and combinations thereof.

7. The method of claim 6 wherein a total concentration of cannabinoids in the CE is between 65% and 99%.

8. The method of claim 1 wherein the composition further comprises at least one additional compound selected from the group consisting of: a terpene, a polyphenol, an essential fatty acid, a phytonutrient, and combinations thereof; and

wherein the at least one additional compound makes up between 0.1% and 50% of a total weight of the composition.

9. The method of claim 1 wherein the composition comprises an oil or a fat as a carrier.

10. The method of claim 7 wherein the total concentration of the CE within the composition is at least 60% by weight.

11. The method of claim 5 comprising at least two or more of the at least one other cannabinoid.

12. A method of treating endometrial cancer comprising:

a. taking a cancerous cell from a patient and forming an organoid from the cancerous cell;

b. performing a screen on the organoid to determine a chemotherapeutic drug capable of reducing the percent of viable organoids by 50%;

c. administering to the patient the chemotherapeutic drug with an effective amount of a composition comprising a cannabis extract (CE) having between 50% and 99.9% cannabidiol (CBD) wherein the composition comprises a pH of between 3.5 and 6; and

d. wherein the CE is administered to the patient as an intravaginal form.

13. The method of claim 12 wherein a total concentration of cannabinoids in the CE is between 65% and 99%.

14. The method of claim 12 wherein the composition further comprises at least one additional compound selected from the group consisting of: a terpene, a polyphenol, an essential fatty acid, a phytonutrient, and combinations thereof; and wherein the at least one additional compound makes up between 0.1% and 50% of a total weight of the composition.

15. The method of claim 12 wherein the composition comprises an oil or a fat as a carrier.

16. The method of claim 12 wherein the CE is a broad spectrum hemp extract (BSHE) or a full spectrum hemp extract (FSHE) and wherein each of the BSHE or FSHE comprises between 60% and 99% by weight of CBD and at least one other cannabinoid at a concentration of 0.1% to 10% by weight wherein the at least one other cannabinoid is selected from the group consisting of:

Δ-9-tetrahydrocannabinol (Δ 9 -THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), Δ-8-tetrahydrocannabinol (Δ 8 -THC), cannabichromene (CBC), cannabichromene acid (CBCA), cannabigerol (CBG), cannabigerol acid (CBGA), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabicyclol (CBL), and combinations thereof.

17. The method of claim 12 wherein the CE comprises cannabidiol (CBD) at a concentration of between 60% and 99% and at least one other cannabinoid at a concentration of 0.1% to 10% wherein the at least one other cannabinoid is selected from the group consisting of:

Δ-9-tetrahydrocannabinol (Δ 9 -THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), Δ-8-tetrahydrocannabinol (Δ 8 -THC), cannabichromene (CBC), cannabichromene acid (CBCA), cannabigerol (CBG), cannabigerol acid (CBGA), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabicyclol (CBL), and combinations thereof.

18. The method of claim 12 wherein the composition further comprises a carrier and wherein the CE is 50% to 99% of a total weight of the composition.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2025
From: ECOFIBRE USA, INC.
To: DOVE INNOVATION PTY LIMITED
Reel/Frame 072141/0535 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2023
From: CAPANO, ALEXANDRA M.
To: ECOFIBRE USA INC.
Reel/Frame 065064/0752 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2023
From: TANWAR, PRADEEP SINGH
To: THE UNIVERSITY OF NEWCASTLE
Reel/Frame 065064/0866 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2023
From: NANCE, ALEX
To: ECOFIBRE USA INC.
Reel/Frame 065064/0955 →
Continuity (5)
Continuation 18050021 · Oct 26, 2022
Provisional Application 63263018 · Oct 26, 2021
Provisional Application 63263026 · Oct 26, 2021
Provisional Application 63263020 · Oct 26, 2021
Related Publication 20240000876A1 · Jan 4, 2024
References Cited (103)
US 10098867B2 · Javid et al. · 2018 [cited by applicant]
US 11123308B2 · Yu et al. · 2021 [cited by applicant]
US 20100273895A1 · Stinchcomb et al. · 2010 [cited by applicant]
US 20110086113A1 · Velasco Diez et al. · 2011 [cited by applicant]
US 20150086653A1 · Parolaro et al. · 2015 [cited by applicant]
US 20160136128A1 · Javid et al. · 2016 [cited by applicant]
US 20190282513A1 · Yerike · 2019 [cited by applicant]
US 20200253919A1 · Raz et al. · 2020 [cited by applicant]
US 20200408740A1 · Ballan et al. · 2020 [cited by applicant]
US 20210052512A1 · Guy et al. · 2021 [cited by applicant]
US 20210068444A1 · Alarcon et al. · 2021 [cited by applicant]
US 20210069608A1 · Galyuk · 2021 [cited by applicant]
US 20210085638A1 · Hospodor · 2021 [cited by applicant]
US 20210128521A1 · Palaio · 2021 [cited by applicant]
US 20210145764A1 · Lephart · 2021 [cited by applicant]
US 20220000774A1 · Dely · 2022 [cited by applicant]
US 20220054429A1 · Nathan et al. · 2022 [cited by applicant]
US 20220062224A1 · Gubler et al. · 2022 [cited by applicant]
US 20220193164A1 · White · 2022 [cited by applicant]
US 20220202765A1 · Altman et al. · 2022 [cited by applicant]
US 20220248619A1 · Kleidon · 2022 [cited by applicant]
US 20220253919A1 · Denner · 2022 [cited by applicant]
US 20220331287A1 · Morgan et al. · 2022 [cited by applicant]
US 20230015268A1 · Altman et al. · 2023 [cited by applicant]
US 20230127098A1 · Capano et al. · 2023 [cited by applicant]
US 20230132189A1 · Capano et al. · 2023 [cited by applicant]
US 20230248747A1 · Altman et al. · 2023 [cited by applicant]
US 20230355645A1 · Storch et al. · 2023 [cited by applicant]
CN 108433880A · 2018 [cited by applicant]
CN 110063953A · 2019 [cited by applicant]
EP 3368024A1 · 2018 [cited by applicant]
EP 3449992A1 · 2019 [cited by applicant]
EP 3544598A1 · 2019 [cited by applicant]
EP 3915550A1 · 2021 [cited by applicant]
EP 3937914A1 · 2022 [cited by applicant]
GB 2516335A · 2015 [cited by applicant]
RU 2745687C1 · 2021 [cited by applicant]
WO WO2013165251A1 · 2013 [cited by applicant]
WO WO2014057067A1 · 2014 [cited by applicant]
WO WO2016187679A1 · 2016 [cited by applicant]
WO WO2017072773A1 · 2017 [cited by applicant]
WO WO2018167038A1 · 2018 [cited by applicant]
WO WO2019003163A2 · 2019 [cited by applicant]
WO WO2019034113A1 · 2019 [cited by applicant]
WO WO2019106652A1 · 2019 [cited by applicant]
WO WO2019145552A1 · 2019 [cited by applicant]
WO WO2019195943A1 · 2019 [cited by applicant]
WO WO2019222459A1 · 2019 [cited by applicant]
WO WO2020036655A9 · 2020 [cited by applicant]
WO WO2020163775A1 · 2020 [cited by applicant]
WO WO2020165878A1 · 2020 [cited by applicant]
WO WO2020183455A1 · 2020 [cited by applicant]
WO WO2020194237A1 · 2020 [cited by applicant]
WO WO2020209902A1 · 2020 [cited by applicant]
WO WO2021011790A1 · 2021 [cited by applicant]
WO WO2021016718A1 · 2021 [cited by applicant]
WO WO2021028646A1 · 2021 [cited by applicant]
WO WO2021099792A1 · 2021 [cited by applicant]
WO WO2021130728A1 · 2021 [cited by applicant]
WO WO2021158251A1 · 2021 [cited by applicant]
WO WO2021235977A1 · 2021 [cited by applicant]
WO WO2021240510A1 · 2021 [cited by applicant]
WO WO2021245522A1 · 2021 [cited by applicant]
WO WO2022013854A1 · 2022 [cited by applicant]
WO WO2022016160A1 · 2022 [cited by applicant]
WO WO2022018708A1 · 2022 [cited by applicant]
WO WO2022105952A1 · 2022 [cited by applicant]
WO WO2022118303A1 · 2022 [cited by applicant]
WO WO2022144878A1 · 2022 [cited by applicant]
WO WO2022165349A1 · 2022 [cited by applicant]
WO WO2022165439A1 · 2022 [cited by applicant]
WO WO2022201043A1 · 2022 [cited by applicant]
WO WO2022215071A1 · 2022 [cited by applicant]
WO WO2022225658A1 · 2022 [cited by applicant]
WO WO2023287742A1 · 2023 [cited by applicant]
WO WO2023014818A2 · 2023 [cited by applicant]
WO WO2023062634A1 · 2023 [cited by applicant]
Boretto, M.; Maenhoudt, N.; Luo, X.; Hennes, Aurelie; Boeckx, B.; Bui, B.; Heremans, R.; Perneel, L.; Kobayashi, H,; Van Zundert, I.; Brems, H. Patient-derived organoids from endometrial disease capture clinical heterog… [cited by examiner]
Midatech Pharma US Inc., Soltamox® Product Label, Revised Apr. 2019. [cited by applicant]
Olivas-Aguirre, et al., “Tamoxifen Sensitizes Acute Lymphoblastic Leukemia Cells to Cannabidiol by Targeting Cyclophilin-D and Altering Mitochondrial Ca [cited by applicant]
Van Weelden, et al., “Anti-Estrogen Treatment in Endometrial Cancer: A Systematic Review”, Frontiers in Oncology, vol. 9, art. 359, May 7, 2019, 1-12. [cited by applicant]
International Search Report issued in International Application No. PCT/US2022/078698 dated Dec. 14, 2022. [cited by applicant]
International Search Report issued in International Application No. PCT/US2022/078701 dated Feb. 15, 2023. [cited by applicant]
International Search Report issued in International Application No. PCT/US2022/078691 dated Jan. 30, 2023. [cited by applicant]
International Search Report issued in International Application No. PCT/US2022/078693 dated Jan. 30, 2023. [cited by applicant]
International Search Report issued in International Application No. PCT/US2022/078694 dated Jun. 9, 2023. [cited by applicant]
Armour, et al., “Self-Management Strategies Amongst Australian Women With Endometriosis: A National Online Survey”, BMC Complementary and Alternative Medicine, vol. 19, No. 1, art. 17, Jan. 15, 2019, 1-8. [cited by applicant]
Escudero-Lara, et al., “Disease-Modifying Effects of Natural Δ [cited by applicant]
Fonseca, et al., “Cannabinoid-Induced Cell Death in Endometrial Cancer Cells: Involvement of TRPV1 Receptors in Apoptosis”, Journal of Physiology and Biochemistry, vol. 74, No. 2, Feb. 13, 2018, 261-272. [cited by applicant]
Fraguas-Sánchez, et al., “Enhancing Ovarian Cancer Conventional Chemotherapy Through the Combination With Cannabidiol Loaded Microparticles”, European Journal of Pharmaceutics and Biopharmaceutics, vol. 154, Jul. 17, 20… [cited by applicant]
Go, et al., “Cannabidiol Enhances Cytotoxicity of Anti-Cancer Drugs in Human Head and Neck Squamous Cell Carcinoma”, Scientific Reports, vol. 10, No. 1, art. 20622, Nov. 26, 2020, 1-11. [cited by applicant]
Griffiths, et al., “Cannabidiol Suppresses 3-Dimensional Ovarian Cancer Growth and May Enhance Potency of Classic and Epigenetic Therapies”, Gynecologic Oncology, vol. 162, suppl. 1, Abstracts for the 2021 Society of Gy… [cited by applicant]
Hazekamp, et al., “Preparative Isolation of Cannabinoids from Cannabis sativa by Centrifugal Partition Chromatography”, Journal of Liquid Chromatography & Related Technologies, vol. 27, No. 15, 2004, 2421-2439. [cited by applicant]
Jaidee, et al., “Kinetics of CBD, A9-THC Degradation and Cannabinol Formation in Cannabis Resin at Various Temperature and pH Conditions”, Cannabis and Cannabinoid Research, vol. 7, No. 4, Aug. 9, 2022, 1-11. [cited by applicant]
Jin, et al., “Identification of Chemotypic Markers in Three Chemotype Categories of Cannabis Using Secondary Metabolites Profiled in Inflorescences, Leaves, Stem Bark, and Roots”, Frontiers in Plant Science, vol. 12, ar… [cited by applicant]
Kenyon, et al., “Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-Grade Synthetic Cannabidiol”, Anticancer Research, vol. 38, No. 10, Oct. 1, 2018, 5831-5835. [cited by applicant]
Lazarjani, et al., “Processing and Extraction Methods of Medicinal Cannabis: A Narrative Review”, Journal of Cannabis Research, vol. 3, art. 32, Jul. 19, 2021, 1-15. [cited by applicant]
Marinelli, et al., “The Effects of Cannabidiol and Prognostic Role of TRPV2 in Human Endometrial Cancer”, International Journal of Molecular Sciences, vol. 21, No. 15, art. 5409, Jul. 29, 2020, 1-22. [cited by applicant]
Marinotti, et al., “Differentiating Full-Spectrum Hemp Extracts from CBD Isolates: Implications for Policy, Safety and Science”, Journal of Dietary Supplements, vol. 17, No. 5, Jun. 16, 2020, 517-526. [cited by applicant]
Ökten, et al., “Cannabidiol as a Potential Novel Treatment for Endometriosis by Its Anti-Inflammatory and Anti-Oxidative Effects in an Experimental Rat Model”, Human Reproduction, vol. 37, issue supp. 1, Jun. 30, 2022, … [cited by applicant]
Rais, et al., “Phytochemicals in the Treatment of Ovarian Cancer”, Frontiers in Bioscience-Elite, vol. 9, No. 1, Jan. 1, 2017, 67-75. [cited by applicant]
Rush, et al., “Cannabidiol: Assessing Activity in Ovarian and Endometrial Carcinoma Cell Lines”, Abstracts for the 2021 Society of Gynecologic Oncology 52nd Annual Meeting on Women's Cancer, Featured Posters 188—Poster … [cited by applicant]
Sumanasekera, et al., “Hemp Extract With Specific Anti-Cancer Properties Against Ovarian Cancer”, The FASEB Journal Special Issue: Experimental Biology 2021 Meeting Abstracts, vol. 35, No. S1, May 14, 2021, https://doi.… [cited by applicant]