IP Library › Granted Patent US 11,654,172
Granted Patent B2
US 11,654,172 · App. 18/050,023 · Granted May 23, 2023

Methods of treating endometriosis and other non-cancer gynecological disorders with hemp extract

Inventors: Alexandra M. Capano (Philadelphia, PA); Pradeep Singh Tanwar (Fletcher, AU); Alex Nance (Georgetown, KY)
Assignees: Ecofibre Limited; The University of Newcastle
A61K36/185A61K31/015A61K31/045A61K31/05A61K31/352A61K31/353A61K31/60A61P35/00
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Quick Facts
Patent No.
US 11,654,172
App. No.
18/050,023
Granted
May 23, 2023
Kind
B2
Abstract

A method for treating a noncancerous gynecological disorder comprising: administering to a patient and effective amount of composition comprising a cannabis extract comprising cannabidiol (CBD), wherein the composition is preferably administered in a mucosal form, such as intravaginally.

Claims (16)

1. A method for treating a noncancerous gynecological disorder (NCGD) selected from the group consisting of: ovarian endometrioma, a deep endometriosis, dysmenorrhea, and fibroids; the method comprising administering to a patient an effective amount of a composition comprising a cannabis extract (CE) comprising cannabidiol (CBD), wherein the composition has a pH of between 3.5 and 6.

2. The method of claim 1 wherein the CE comprises between 50% and 99.9% by weight of CBD.

3. The method of claim 1 wherein the CE is selected from the group consisting of: a full spectrum hemp extract (FSHE), a broad spectrum hemp extract (BSHE), and a cannabidiol (CBD) isolate.

4. The method of claim 1 wherein the CE is administered via an oral form, oral mucosal form, intravaginal form, nasal mucosal form, rectal form, injectable form, or combinations thereof.

5. The method of claim 1 wherein the effective amount of the CE comprises between 10 mg and 4,250 mg of cannabidiol (CBD) per day.

6. The method of claim 1 wherein the CE further comprises a cannabidiolic acid (CBDA) at a concentration of between 0.1% and 10%.

7. The method of claim 1 wherein the CE is a broad spectrum hemp extract (BSHE) or a full spectrum hemp extract (FSHE) and wherein each of the BSHE or FSHE comprises 50% to 99% by weight of cannabidiol (CBD) and at least one other cannabinoid at a concentration of 0.1% to 10% wherein the at least one other cannabinoid is selected from the group consisting of: Δ-9-tetrahydrocannabinol (Δ 9 -THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), Δ-8-tetrahydrocannabinol (Δ 8 -THC), cannabichromene (CBC), cannabichromene acid (CBCA), cannabigerol (CBG), cannabigerol acid (CBGA), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabicyclol (CBL), and combinations thereof.

8. The method of claim 1 wherein the CE comprises cannabidiol (CBD) at a concentration of between 60% and 99% and at least one other cannabinoid at a concentration of 0.1% to 10% wherein the at least one other cannabinoid is selected from the group consisting of: Δ-9-tetrahydrocannabinol (Δ 9 -THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), Δ-8-tetrahydrocannabinol (Δ 8 -THC), cannabichromene (CBC), cannabichromene acid (CBCA), cannabigerol (CBG), cannabigerol acid (CBGA), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabicyclol (CBL), and combinations thereof, and wherein the CE comprises a total concentration of cannabinoids of between 65% and 99%.

9. The method of claim 1 wherein the composition comprises at least one additional compound selected from the group consisting of: a terpene, a polyphenol, an essential fatty acid, a phytonutrient, and combinations thereof; and wherein the at least one additional compound makes up between 0.1% and 50% by weight of the composition.

10. The method of claim 1 wherein the composition comprises an oil or a fat as a carrier.

11. The method of claim 1 wherein the effective amount of the composition is an amount sufficient to reach an effective therapeutic level of cannabidiol (CBD) as measured through systemic plasma levels.

12. The method of claim 9 wherein:

a. the terpene is selected from the group consisting of: β-myrcene, β-caryophyllene, linalool, α-pinene, citral, D -limonene, eucalyptol, and combinations thereof;

b. wherein the polyphenol is selected from the group consisting of: catechins, quercetin, cannflavin A/B/C, rutin, chlorogenic acid, and combinations thereof;

c. wherein the essential fatty acid is selected from the group consisting of: an omega 3, an omega 6, an omega 9, and combinations thereof, and

d. wherein the phytonutrient is selected from the group consisting of: a tocopherol, a sterol, carotene, an aliphatic alcohol, a mineral, and combinations thereof.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2025
From: ECOFIBRE USA, INC.
To: DOVE INNOVATION PTY LIMITED
Reel/Frame 072141/0535 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 2, 2023
From: ECOFIBRE LIMITED
To: ECOFIBRE USA INC.
Reel/Frame 064464/0611 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2023
From: CAPANO, ALEXANDRA M.
To: ECOFIBRE LIMITED
Reel/Frame 062984/0190 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2023
From: NANCE, ALEX
To: ECOFIBRE LIMITED
Reel/Frame 062984/0589 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2023
From: TANWAR, PRADEEP SINGH
To: THE UNIVERSITY OF NEWCASTLE
Reel/Frame 062984/0730 →
Continuity (4)
Provisional Application 63263026 · Oct 26, 2021
Provisional Application 63263020 · Oct 26, 2021
Provisional Application 63263022 · Oct 26, 2021
Related Publication 20230127098A1 · Apr 27, 2023