Encapsulation of gastric residence systems
Compactable gastric residence systems comprising therapeutic agent formulations for sustained gastric release of therapeutic agents are disclosed, as well as methods and systems for encapsulating such gastric residence systems. The methods and systems for encapsulating the gastric residence systems can be automated from receiving a bulk of gastric residence systems, orienting, placing, compacting, securing, and encapsulating the gastric residence systems.
1. A compacting system for compacting a gastric residence system comprising:
a tapered tube comprising an upper circular surface;
a primary piston configured to advance into a center of the tapered tube and through the upper circular surface; and
a secondary piston configured to receive the primary piston when in a retracted configuration,
wherein the primary piston is configured to apply a first force to a linking member of the gastric residence system, and the upper circular surface of the tapered tube is configured to apply a second force to a plurality of arms of the gastric residence system, causing the gastric residence system to fold, wherein each arm of the plurality of arms is attached to the linking member at a proximal end of the arm.
2. The compacting system of claim 1 , wherein the secondary piston is configured to engage with the distal ends of the arms of the gastric residence system to continue pressing the gastric residence system through the tapered tube until the gastric residence system is fully folded in a compacted configuration.
3. The compacting system of claim 2 , wherein the secondary piston is configured to press the gastric residence system through the tapered tube and into a container.
4. The compacting system of claim 1 , wherein the upper circular surface of the tapered tube is configured to come in contact with a distal end of each arm of the plurality of arms.
5. The compacting system of claim 1 , wherein an edge of the distal end of each arm rests on the upper circular surface of the tapered tube.
6. The compacting system of claim 1 , wherein a bending force of the gastric residence system is at least about 0.1 newtons when the gastric residence system is in an open configuration.
7. The compacting system of claim 1 , wherein a bending force of the gastric residence system is at least about 0.2 newtons when the arms of the gastric residence system are bent more than 5 degrees relative to the arms in an open configuration.
8. The compacting system of claim 1 , wherein a bending force of the gastric residence system is at least about 0.2 newtons when the arms of the gastric residence system are bent more than 10 degrees relative to the arms in an open configuration.
9. The compacting system of claim 1 , wherein a bending force of the gastric residence system is at least about 0.2 newtons when the arms of the gastric residence system are bent more than 45 degrees relative to the arms in an open configuration.
10. The compacting system of claim 1 , wherein the upper circular surface is polished to reduce friction between the gastric residence system and the upper circular surface of the tapered tube.
11. The compacting system of claim 1 , wherein the upper circular surface is coated with biocompatible fluoropolymers to reduce friction between the gastric residence system and the upper circular surface of the tapered tube.
12. The compacting system of claim 1 , wherein a contact surface area of the primary piston is about 15 square millimeters.
13. The compacting system of claim 1 , wherein a contact surface area of the secondary piston is larger than a contact area of the primary piston.
14. The compacting system of claim 1 , wherein the tapered tube has a top opening defined by the upper circular surface, and a diameter of the top opening is about 30 to about 50 millimeters.
15. The compacting system of claim 1 , wherein the tapered tube has a bottom opening opposite the top opening, and a diameter of the bottom opening is at least about 8.2 millimeters.
16. The compacting system of claim 1 , wherein a taper angle of the tapered tube is about 5 to about 60 degrees.
17. The compacting system of claim 3 , wherein the container is a half-capsule.