IP Library Granted Patent US 12,109,434
Granted Patent B2
US 12,109,434 · App. 18/527,066 · Granted Oct 8, 2024

Neural network calibration for radiotherapy

Inventors: Mikko Hakala (Rajamaki, FI); Esa Kuusela (Espoo, FI); Elena Czeizler (Helsinki, FI); Shahab Basiri (Siuntio, FI)
Assignee: Siemens Healthineers International AG
A61N5/1064G06N3/045G06N3/08G06N20/00
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Quick Facts
Patent No.
US 12,109,434
App. No.
18/527,066
Granted
Oct 8, 2024
Kind
B2
Abstract

Disclosed herein are systems and methods for identifying radiation therapy treatment data for patients. A processor accesses a neural network trained based on a first set of data generated from characteristic values of a first set of patients that received treatment at one or more first radiotherapy machines. The processor executes the neural network using a second set of data comprising characteristic values of a second set of patients receiving treatment at one or more second radiotherapy machines. The processor executes a calibration model using an output of the neural network based on the second set of data to output a calibration value. The processor executes the neural network using a set of characteristics of a first patient to output a first confidence score associated with a first treatment attribute. The processor then adjusts the first confidence score according to the calibration value to predict the first treatment attribute.

Claims (41)

1. A method comprising:

retrieving, by one or more processors via a radiation therapy treatment generation (RTTP) model, a set of treatment attribute predictions for a radiotherapy treatment of a patient;

executing, by the one or more processors, a calibration model using the set of treatment attribute predictions and a set of labels indicating expected treatment attribute predictions to predict a calibration value; and

revising, by the one or more processors, at least one configuration of the RTTP model using the calibration value.

2. The method of claim 1 , further comprising:

responsive to revising the at least one configuration of the RTTP model, executing, by the one or more processors, the calibration model to predict a second calibration value.

3. The method of claim 1 , wherein the RTTP model is initially partially trained and then calibrated using the calibration model.

4. The method of claim 1 , wherein the calibration value corresponds to a clinic, such that the RTTP model is trained for the clinic.

5. The method of claim 1 , further comprising:

adjusting, by the one or more processors, a configuration of a radiotherapy machine according to at least one treatment attribute prediction generated by the RTTP model.

6. The method of claim 1 , wherein the calibration model is one of a machine learning model or a mathematical optimization algorithm.

7. The method of claim 1 , further comprising:

generating, by the one or more processors, a confidence score for the set of treatment attribute predictions generated using the RTTP model.

8. The method of claim 1 , wherein at least one treatment attribute prediction within the set of treatment attribute predictions is an angle associated with a couch or a gantry of a radiotherapy machine.

9. A system comprising:

at least one processor;

a computer readable medium comprising a set of instructions, that when executed, cause the at least one processor to:

retrieve, via a radiation therapy treatment generation (RTTP) model, a set of treatment attribute predictions for a radiotherapy treatment of a patient;

execute a calibration model using the set of treatment attribute predictions and a set of labels indicating expected treatment attribute predictions to predict a calibration value; and

revise at least one configuration of the RTTP model using the calibration value.

10. The system of claim 9 , wherein the set of instructions further cause the at least one processor to:

responsive to revising the at least one configuration of the RTTP model, execute the calibration model to predict a second calibration value.

11. The system of claim 9 , wherein the RTTP model is initially partially trained and then calibrated using the calibration model.

12. The system of claim 9 , wherein the calibration value corresponds to a clinic, such that the RTTP model is trained for the clinic.

13. The system of claim 9 , wherein the set of instructions further cause the at least one processor to:

adjust a configuration of a radiotherapy machine according to at least one treatment attribute prediction generated by the RTTP model.

14. The system of claim 9 , wherein the calibration model is one of a machine learning model or a mathematical optimization algorithm.

15. The system of claim 9 , wherein the set of instructions further cause the at least one processor to:

generate a confidence score for the set of treatment attribute predictions generated using the RTTP model.

16. The system of claim 9 , wherein at least one treatment attribute prediction within the set of treatment attribute predictions is an angle associated with a couch or a gantry of a radiotherapy machine.

17. A system comprising:

a radiation therapy treatment generation (RTTP) model;

a calibration model;

a server in communication with the RTTP model and the calibration model, the server configured to:

retrieve, via the RTTP model, a set of treatment attribute predictions for a radiotherapy treatment of a patient;

execute the calibration model using the set of treatment attribute predictions and a set of labels indicating expected treatment attribute predictions to predict a calibration value; and

revise at least one configuration of the RTTP model using the calibration value.

18. The system of claim 17 , wherein the server is further configured to:

responsive to revising the at least one configuration of the RTTP model, execute the calibration model to predict a second calibration value.

19. The system of claim 17 , wherein the RTTP model is initially partially trained and then calibrated using the calibration model.

20. The system of claim 17 , wherein the calibration value corresponds to a clinic, such that the RTTP model is trained for the clinic.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 1, 2023
From: HAKALA, MIKKO; KUUSELA, ESA; CZEIZLER, ELENA; BASIRI, SHAHAB
To: VARIAN MEDICAL SYSTEMS, INC.
Reel/Frame 065739/0589 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 1, 2023
From: VARIAN MEDICAL SYSTEMS INC.
To: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
Reel/Frame 065739/0644 →
MERGER AND CHANGE OF NAME Recorded Dec 1, 2023
From: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG; SIEMENS HEALTHINEERS INTERNATIONAL AG
To: SIEMENS HEALTHINEERS INTERNATIONAL AG
Reel/Frame 065746/0432 →
Continuity (3)
Continuation 18114826 · Feb 27, 2023
Continuation 17124223 · Dec 16, 2020
Related Publication 20240115883A1 · Apr 11, 2024