IP Library › Granted Patent US 12,357,674
Granted Patent B2
US 12,357,674 · App. 18/529,590 · Granted Jul 15, 2025

Methods for promoting wound healing and hair growth comprising GDNF administration

Inventors: Robert E. Braun (Bar Harbor, ME); Manju Sharma (Bar Harbor, ME)
Assignee: The Jackson Laboratory
A61K38/185A61G7/00A61K8/64C07K14/4756
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Quick Facts
Patent No.
US 12,357,674
App. No.
18/529,590
Granted
Jul 15, 2025
Kind
B2
Abstract

The present invention generally relates to uses of glial cell line-derived growth factor (GDNF) in cutaneous wound healing and hair growth. Methods of effecting hair growth and/or wound healing which feature administration of GDNF, or a biologically active fragment thereof, to subjects, e.g., human subject, are disclosed herein. The invention relates also to formulations and kits for achieving the indicated pharmaceutical advantages.

Claims (21)

1. A method for promoting hair growth comprising:

administering to skin comprising hair follicles of a subject in need thereof a therapeutically effective amount of a topical formulation comprising recombinant human glial cell-derived neurotrophic factor (GDNF), wherein the therapeutically effective amount increases the number of hair follicles in the skin of the subject.

2. The method of claim 1 , wherein the subject has androgenetic alopecia.

3. The method of claim 1 , wherein the subject has acute or chronic telogen effluvium.

4. The method of claim 1 , wherein the topical formulation is administered to the scalp of the subject.

5. The method of claim 1 , wherein the topical formulation is an emulsion.

6. The method of claim 5 , wherein the emulsion is a continuous phase emulsion.

7. The method of claim 5 , wherein the emulsion is a disperse phase emulsion.

8. The method of claim 5 , wherein the emulsion is a cream, lotion, ointment, or gel.

9. The method of claim 5 , wherein the emulsion is an oil-in-water emulsion or a water-in-oil emulsion.

10. The method of claim 5 , wherein the emulsion is a microemulsion.

11. The method of claim 1 , wherein the therapeutically effective amount is administered daily for at least 3-5 days.

12. The method of claim 1 , wherein the subject is a female.

13. A method for promoting hair growth comprising:

administering to the scalp of a subject a therapeutically effective amount of a topical formulation comprising recombinant human glial cell-derived neurotrophic factor (GDNF), wherein the therapeutically effective amount increases the number of hair follicles in the scalp of the subject, and wherein the subject has androgenetic alopecia.

14. The method of claim 13 , wherein the subject is female.

15. The method of claim 13 , wherein the topical formulation is an emulsion.

16. A method for promoting hair growth comprising:

administering to the scalp of a subject a therapeutically effective amount of a topical formulation comprising recombinant human glial cell-derived neurotrophic factor (GDNF), wherein the therapeutically effective amount increases the number of hair follicles in the scalp of the subject, and wherein the subject has acute or chronic telogen effluvium.

17. The method of claim 16 , wherein the subject is female.

18. The method of claim 16 , wherein the topical formulation is an emulsion.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 5, 2024
From: BRAUN, ROBERT E.; SHARMA, MANJU
To: THE JACKSON LABORATORY
Reel/Frame 066644/0531 →
Continuity (5)
Continuation 17373877 · Jul 13, 2021
Continuation 16452459 · Jun 25, 2019
Division 14775386
Provisional Application 61787870 · Mar 15, 2013
Related Publication 20240181008A1 · Jun 6, 2024
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