IP Library › Granted Patent US 12,172,960
Granted Patent B2
US 12,172,960 · App. 18/604,747 · Granted Dec 24, 2024

Organic compound salts

Inventors: Julian Northen (Sunderland, GB); Gillian Moore (Sunderland, GB); Jake Parker (Sunderland, GB)
Assignee: GH RESEARCH IRELAND LIMITED
C07D209/16A61K31/4045
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Quick Facts
Patent No.
US 12,172,960
App. No.
18/604,747
Granted
Dec 24, 2024
Kind
B2
Abstract

Crystalline hydrobromide salt of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT HBr).

Claims (22)

1. A hydrobromide salt of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in crystalline form, comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 2θ values of 14.5°±0.2°, 16.7°±0.2°, 20.7°±0.2°, 24.2°±0.2°, 24.8°±0.2° and 27.4°±0.2° as measured using an x-ray wavelength of 1.5406 Å.

2. A hydrobromide salt of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in crystalline form, comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 2θ values of 14.5°±0.2 20 , 21.4°±0.2° and 24.2°±0.2° as measured using an x-ray wavelength of 1.5406 Å.

3. A hydrobromide salt of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in crystalline form, comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 2θ values of 18.7°±0.2°,19.6°±0.2° and 24.7°±0.2° as measured using an x-ray wavelength of 1.5406 Å.

4. The salt of claim 2 , comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 20 values of 14.5°±0.2°, 20.7°+0.2°, 21.4°±0.2°, 24.2°±0.2°, and 25.3°±0.2° as measured using an x-ray wavelength of 1.5406 Å.

5. A pharmaceutical composition comprising the salt of claim 1 .

6. A pharmaceutical composition comprising the salt of claim 2 .

7. A pharmaceutical composition comprising the salt of claim 3 .

8. A pharmaceutical composition comprising the salt of claim 4 .

9. A hydrobromide salt of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in crystalline form, comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 2θ values of 14.5°±0.2°, 17.0°±0.2° and 24.2°±0.2° as measured using an x-ray wavelength of 1.5406 Å.

10. The salt of claim 9 , comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 20 values of 14.5°±0.2°, 16.7°+0.2°, 17.0°±0.2°, 20.7°±0.2°, 24.2°±0.2°, 24.8°±0.2°, and 27.4°±0.2° as measured using an x-ray wavelength of 1.5406 Å.

11. A hydrobromide salt of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in crystalline form, comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 2 θ values of 14.5°±0.2°, 17.0°±0.2 20 , 20.6°±0.2°, 20.7°±0.2° and 24.2°±0.2 as measured using an x-ray wavelength of 1.5406 Å.

12. The salt of claim 3 , comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 20 values of 13.8°±0.2°, 14.5°±0.2°, and 23.4°±0.2° as measured using an x-ray wavelength of 1.5406 Å.

13. The salt of claim 3 , comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 20 values of 13.8°±0.2°, 14.5°±0.2°, 23.4°±0.2°, 27.3°±0.2°, and 24.9°±0.2° as measured using an x-ray wavelength of 1.5406 Å.

14. A pharmaceutical composition comprising the salt of claim 9 .

15. A pharmaceutical composition comprising the salt of claim 10 .

16. A pharmaceutical composition comprising the salt of claim 11 .

17. A pharmaceutical composition comprising the salt of claim 12 .

18. A pharmaceutical composition comprising the salt of claim 13 .

19. A hydrobromide salt of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in crystalline form, comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 2θ values of 14.5°, 16.7°, 20.7°, 24.2°, 24.8° and 27.4° as measured using an x-ray wavelength of 1.5406 Å.

20. A hydrobromide salt of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in crystalline form, comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 2θ values of 14.5°, 21.6° and 24.2° as measured using an x-ray wavelength of 1.5406 Å.

21. A hydrobromide salt of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in crystalline form, comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 2θ values of 18.7°, 19.6° and 24.7° as measured using an x-ray wavelength of 1.5406 Å.

22. The salt of claim 20 , comprising peaks in an x-ray powder diffraction (XRPD) diffractogram at 2θ values of 14.5°, 20.7°, 21.6°, 24.2° and 25.3° as measured using an x-ray wavelength of 1.5406 Å.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2024
From: NORTHEN, JULIAN; MOORE, GILLIAN; PARKER, JAKE
To: GH RESEARCH IRELAND LIMITED
Reel/Frame 069014/0468 →
Priority Claims (1)
EP 22000081 · Mar 27, 2022 · regional
Continuity (2)
Continuation PCTEP2023057882 · Mar 27, 2023
Related Publication 20240228440A1 · Jul 11, 2024
Cited By (2)
US 12,612,363 US 12,685,721