IP Library › Granted Patent US 12,698,341
Granted Patent B2
US 12,698,341 · App. 18/652,669 · Granted Aug 4, 2026

Antigen binding domains that bind to mesothelin (MSLN)

Inventors: John R. Desjarlais (Pasadena, CA); Matthew Bernett (Monrovia, CA); Michael Hedvat (Encino, CA); Veronica Gusti Zeng (Monrovia, CA); Matthew S. Faber (Monrovia, CA)
Assignee: Xencor, Inc.
C07K16/3069C07K16/2809A61K39/00C07K2317/31C07K2317/56C07K2317/565C07K2317/622
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Quick Facts
Patent No.
US 12,698,341
App. No.
18/652,669
Filed
May 1, 2024
Granted
Aug 4, 2026
Kind
B2
Art Unit
1674
USPC
530/387.3
Abstract

The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Mesothelin (MSLN).

Claims (6)

1 . A mesothelin (MSLN) antigen binding domain comprising a variable heavy domain having at least 90% identity to the amino acid sequence of SEQ ID NO: 241 and a variable light domain having at least 90% identity to the amino acid sequence of SEQ ID NO: 245.

2 . The MSLN antigen binding domain according to claim 1 , wherein said variable heavy domain has at least 95% identity to the amino acid sequence of SEQ ID NO: 241 and said variable light domain has at least 95% identity to the amino acid sequence of SEQ ID NO: 245.

3 . The MSLN antigen binding domain according to claim 1 , wherein said variable heavy domain has the amino acid sequence of SEQ ID NO: 241, and said variable light domain has the amino acid sequence of SEQ ID NO: 245.

4 . An antibody comprising a mesothelin (MSLN) antigen binding domain comprising a variable heavy domain having at least 90% identity to the amino acid sequence of SEQ ID NO: 241 and a variable light domain having at least 90% identity to the amino acid sequence of SEQ ID NO: 245.

5 . The antibody comprising the MSLN antigen binding domain according to claim 4 wherein said variable heavy domain has at least 95% identity to the amino acid sequence of SEQ ID NO: 241 and said variable light domain has at least 95% identity to the amino acid sequence of SEQ ID NO: 245.

6 . The antibody comprising the MSLN antigen binding domain according to claim 4 , wherein said variable heavy domain has the amino acid sequence of SEQ ID NO: 241, and said variable light domain has the amino acid sequence of SEQ ID NO: 245.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 27, 2024
From: DESJARLAIS, JOHN R.; BERNETT, MATTHEW J.; HEDVAT, MICHAEL; GUSTI ZENG, VERONICA; FABER, MATTHEW S.
To: XENCOR, INC.
Reel/Frame 069093/0286 →
Continuity (3)
Continuation 17321272 · May 14, 2021
Provisional Application 63025021 · May 14, 2020
Related Publication 20240279356A1 · Aug 22, 2024
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