Granted Patent B2

US 12,521,555 · App. 18/670,356 · Granted Jan 13, 2026

Inventor: Conor Mulrooney (Manchester, GB)

Assignee: Phagenesis Limited

A61N1/3606A61N1/05A61N1/36128

Abstract

Claims (34)

1 . A method for stimulating nerves proximate a pharynx of a human patient, the method comprising:

positioning a distal portion of a stimulation device at a treatment site within the pharynx, the stimulation device comprising:

an elongated member having a proximal portion configured to be coupled to an energy source and a distal portion configured to be positioned at the treatment site,

a conductive element carried by the distal portion of the elongated member and configured to be coupled to the energy source to deliver energy at the treatment site,

a cover, at least a portion of which is disposed at the distal portion of the elongated member, wherein, during positioning of the distal portion, the cover is in a first position in which the cover is positioned over the conductive element, and

a stop configured to engage the cover to releasably secure the cover in the first position;

moving the cover from the first position in which the cover is positioned over the conductive element to a second position in which the conductive element is exposed at the treatment site; and

delivering energy to the treatment site with a stimulus from the energy source via the conductive element.

2 . The method of claim 1 , further comprising, after delivering energy to the treatment site, moving the cover from the second position to the first position such that the cover is positioned over the conductive element.

3 . The method of claim 2 , further comprising engaging the cover with the stop to releasably secure the cover in the first position.

4 . The method of claim 1 , wherein positioning the distal portion of the stimulation device at the treatment site within the pharynx includes inserting the distal portion of the stimulation device through a nasal cavity of the patient.

5 . The method of claim 1 , wherein positioning the distal portion of the stimulation device includes visualizing an indicator disposed on the elongated member.

6 . The method of claim 5 , wherein the indicator comprises one or more circumferential markings printed on the elongated member.

7 . The method of claim 1 , wherein positioning the distal portion at the treatment site includes positioning the conductive element in apposition with a posterior pharyngeal wall along an oropharynx and/or laryngopharynx.

8 . The method of claim 1 , wherein positioning the distal portion at the treatment site includes positioning the conductive element along the pharynx at a location proximate to a junction between C3 and C4 cervical vertebrae of the patient.

9 . The method of claim 1 , wherein delivering energy to the treatment site includes emitting an electric field via the conductive element.

10 . The method of claim 1 , wherein the stimulus from the energy source is electrical current, and the electrical current is a unipolar square wave.

11 . The method of claim 10 , wherein the unipolar square wave has an amplitude between 1 mA and 50 mA, a frequency of 5 Hz, and a pulse duration of 200 μs.

12 . The method of claim 1 , wherein the stimulus from the energy source is configured to treat dysphagia.

13 . A method for delivering an electrical stimulus to nerves proximate a body lumen of a human patient, the method comprising:

inserting a distal portion of a medical device through a nasal cavity of the patient, the medical device comprising:

a stimulation device comprising an elongated member having a proximal portion, a distal portion, and an electrode carried by the distal portion, wherein the electrode is configured to be coupled to an energy source;

a cover, at least a portion of which is disposed at the distal portion of the elongated member, wherein the cover is movable between (a) a first position in which the cover is positioned over the electrode, and (b) a second position in which the electrode is exposed; and

a slider coupled to a proximal end portion of the cover, the slider being configured to be manipulated by an operator to adjust a position of the cover relative to the electrode;

positioning the distal portion of the stimulation device and the cover in the first position at a treatment site;

manipulating the slider to move the cover from the first position to the second position in which the electrode is exposed; and

delivering energy to the treatment site with a stimulus from the energy source via the electrode.

14 . The method of claim 13 , further comprising, after delivering energy to the treatment site, moving the cover from the second position to the first position such that the cover is positioned over the electrode.

15 . The method of claim 13 , wherein, after positioning the distal portion of the stimulation device and the cover in the first position at the treatment site, determining whether the distal portion of the stimulation device is properly positioned at the treatment site.

16 . The method of claim 15 , wherein determining whether the distal portion of the stimulation device is properly positioned at the treatment site includes viewing an indicator through an oral cavity of the patient.

17 . The method of claim 16 , wherein, based on whether the distal portion of the stimulation device is properly positioned at the treatment site, either inserting the stimulation device further into the nasal cavity or withdrawing the stimulation device from the nasal cavity to reposition the stimulation device.

18 . The method of claim 13 , wherein the stimulus from the energy source is electrical current, and the electrical current is a unipolar square wave.

19 . The method of claim 18 , wherein the unipolar square wave has an amplitude between 1 mA and 50 mA, a frequency of 5 Hz, and a pulse duration of 200 μs.

20 . The method of claim 13 , wherein the stimulus from the energy source is configured to treat dysphagia.

Assignments (1)

Continuity (3)

References Cited (225)