IP Library Granted Patent US 12,512,215
Granted Patent B2
US 12,512,215 · App. 18/760,943 · Granted Dec 30, 2025

Method and system for computer-aided triage of stroke

Inventors: Christopher Mansi (San Francisco, CA); David Golan (San Francisco, CA); Gil Levi (San Francisco, CA); Avraham Wolfson (San Francisco, CA); Maayan Goren (San Francisco, CA)
Assignee: Viz.ai Inc.
G16H40/20G06N3/045G06N3/08G06Q10/06311G06T7/0012G06T7/11G06T7/62G06T11/001G16H10/20G16H15/00G16H30/40G16H50/20G16H50/30G16H80/00G06T2207/20081G06T2207/30016G06T2210/41
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Quick Facts
Patent No.
US 12,512,215
App. No.
18/760,943
Granted
Dec 30, 2025
Kind
B2
Abstract

A system for computer-aided triage includes a router, a remote computing system, and a client application. Additionally or alternatively, the system 100 can include any number of computing systems, servers, storage, lookup table, memory, and/or any other suitable components. A method for computer-aided triage includes receiving a data packet associated with a patient and taken at a first point of care; checking for a suspected condition associated with the data packet; in an event that the suspected condition is detected, determining a recipient based on the suspected condition; and transmitting information to a device associated with the recipient.

Claims (37)

1 . A method, comprising:

generating a set of trained models, comprising:

performing a first training process, comprising training the set of trained models based on a first set of images labeled as positive with respect to a hemorrhage and a second set of images labeled as negative with respect to a hemorrhage;

processing a third set of images using the set of trained models to produce a set of outputs, wherein the set of outputs comprises a set of false positive hemorrhage determinations; and

updating the set of trained models by performing a second training process, comprising training the set of trained models based on the third set of images;

receiving a set of images associated with a patient;

processing the set of images with the set of trained models to detect a suspected hemorrhage, wherein, prior to processing the set of images with the set of trained models, an exclusion criterion is evaluated based on the set of images, comprising checking for a false positive hemorrhage determination caused by a non-physiological event; and

in response to detecting the suspected hemorrhage, triggering an action, the action operable to improve an efficiency of triage of the patient.

2 . The method of claim 1 , wherein training the set of trained models based on the third set of images comprises labeling the third set of images based on the set of false positive hemorrhage determinations and training the set of trained models based on the labeled third set of images.

3 . The method of claim 1 , wherein generating the set of trained models further comprises identifying that the set of outputs comprises the set of false positive determinations.

4 . The method of claim 3 , wherein the set of false positive determinations are identified based on an input from a specialist.

5 . The method of claim 1 , wherein the suspected hemorrhage comprises at least one of: an intracerebral hemorrhage, an intraventricular hemorrhage, an extradural hemorrhage, or a subdural hemorrhage.

6 . The method of claim 1 , wherein the set of trained models comprises a convolutional neural network.

7 . The method of claim 1 , wherein the action is triggered at a user device associated with a specialist.

8 . The method of claim 1 , wherein receiving the set of images, processing the set of images, and triggering the action are performed during triage of the patient.

9 . The method of claim 1 , wherein the second training process is performed after the first training process.

10 . The method of claim 1 , wherein the set of images associated with the patient comprise a set of non-contrast computed tomography (NCCT) images.

11 . A system, comprising:

a computing system, wherein the computing system:

receives a set of images associated with a patient;

automatically detects a potential brain hemorrhage from the set of images using a set of trained models, wherein, prior to detecting the potential brain hemorrhage from the set of images using the set of trained models, an exclusion criterion is evaluated based on the set of images, comprising checking for a false positive hemorrhage determination caused by a non-physiological event;

identifies a set of specialists based on based on the potential brain hemorrhage; and

transmits, to each application of a set of applications, a notification and a set of compressed images based on the set of images; and

the set of applications, each application executing on a mobile user device and associated with a specialist in the set of specialists, wherein each application is configured to display the notification, wherein each application comprises:

a viewer displaying the set of compressed images; and

a messaging center configured to transmit messages between specialists in the set of specialists.

12 . The system of claim 11 , wherein automatically detecting the potential brain hemorrhage from the set of images comprises: segmenting a hyperdense region from the set of images using the set of trained models; and calculating a volume of the segmented hyperdense region.

13 . The system of claim 12 , wherein the volume of the segmented hyperdense region is displayed at the set of applications.

14 . The system of claim 12 , wherein the potential brain hemorrhage is detected upon determining that the volume exceeds a predetermined volume threshold.

15 . The system of claim 14 , wherein the predetermined volume threshold is a value between 0.1 mL and 0.4 mL.

16 . The system of claim 11 , wherein the set of images are recorded during triage of the patient at a first point of care, wherein an application in the set of applications is configured to receive an input from a specialist associated with a second point of care remote from the first point of care, wherein a transfer of the patient from the first point of care to the second point of care is initiated based on the input from the specialist.

17 . The system of claim 11 , wherein the set of images are associated with a first time, wherein the computing system is further configured to:

receive a second set of images associated with the patient, the second set of images associated with a second time, wherein the potential brain hemorrhage has progressed between the first time and the second time; and

determine a comparison based on the first set of images and the second set of images.

18 . The system of claim 11 , wherein the computing system is further configured to receive a read receipt upon a specialist in the set of specialists opening the notification.

19 . The system of claim 11 , wherein the potential brain hemorrhage comprises at least one of: an intracerebral hemorrhage, an intraventricular hemorrhage, an extradural hemorrhage, or a subdural hemorrhage.

20 . The system of claim 11 , wherein the set of images associated with the patient comprise a set of non-contrast computed tomography (NCCT) images.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 9, 2024
From: MANSI, CHRISTOPHER; GOLAN, DAVID; LEVI, GIL; WOLFSON, AVRAHAM; GOREN, MAAYAN
To: VIZ.AI INC.
Reel/Frame 067939/0706 →
Continuity (4)
Continuation 17895778 · Aug 25, 2022
Continuation 16913754 · Jun 26, 2020
Provisional Application 62867566 · Jun 27, 2019
Related Publication 20240355463A1 · Oct 24, 2024
References Cited (124)
US 6349330B1 · Bernadett et al. · 2002 [cited by applicant]
US 8374414B2 · Tang et al. · 2013 [cited by applicant]
US 9307918B2 · Kinrot et al. · 2016 [cited by applicant]
US 9439622B2 · Case et al. · 2016 [cited by applicant]
US 10346979B2 · Mansi et al. · 2019 [cited by applicant]
US 10373315B2 · Mansi et al. · 2019 [cited by applicant]
US 10599984B1 · Wubbels · 2020 [cited by examiner]
US 10733730B2 · Mansi et al. · 2020 [cited by applicant]
US 10835257B2 · Ferrera et al. · 2020 [cited by applicant]
US 10853449B1 · Nguyen et al. · 2020 [cited by applicant]
US 10902602B1 · Mansi et al. · 2021 [cited by applicant]
US 11241169B2 · Kusens et al. · 2022 [cited by applicant]
US 11316941B1 · Jain et al. · 2022 [cited by applicant]
US 11328400B2 · Levi et al. · 2022 [cited by applicant]
US 11462318B2 · Mansi et al. · 2022 [cited by applicant]
US 11521714B1 · Jain et al. · 2022 [cited by applicant]
US 11694807B2 · Golan et al. · 2023 [cited by applicant]
US 20040147840A1 · Duggirala et al. · 2004 [cited by applicant]
US 20040161137A1 · Aben et al. · 2004 [cited by applicant]
US 20050020903A1 · Krishnan et al. · 2005 [cited by applicant]
US 20060140473A1 · Brooksby et al. · 2006 [cited by applicant]
US 20070019846A1 · Bullitt et al. · 2007 [cited by applicant]
US 20080021502A1 · Imielinska et al. · 2008 [cited by applicant]
US 20090028403A1 · Bar-Aviv et al. · 2009 [cited by applicant]
US 20090129649A1 · Djeridane · 2009 [cited by applicant]
US 20090279752A1 · Sirohey et al. · 2009 [cited by applicant]
US 20100106002A1 · Sugiyama et al. · 2010 [cited by applicant]
US 20110028825A1 · Douglas et al. · 2011 [cited by applicant]
US 20110052024A1 · Nowinski · 2011 [cited by applicant]
US 20110116702A1 · Bredno et al. · 2011 [cited by applicant]
US 20110172550A1 · Martin et al. · 2011 [cited by applicant]
US 20120065987A1 · Farooq et al. · 2012 [cited by applicant]
US 20120201446A1 · Yang et al. · 2012 [cited by applicant]
US 20120237103A1 · Hu · 2012 [cited by applicant]
US 20130172691A1 · Tran · 2013 [cited by applicant]
US 20130185096A1 · Giusti et al. · 2013 [cited by applicant]
US 20130208955A1 · Zhao et al. · 2013 [cited by applicant]
US 20130208966A1 · Zhao et al. · 2013 [cited by applicant]
US 20140142982A1 · Janssens · 2014 [cited by applicant]
US 20140142983A1 · Backhaus et al. · 2014 [cited by applicant]
US 20140222444A1 · Cerello et al. · 2014 [cited by applicant]
US 20140257854A1 · Becker et al. · 2014 [cited by applicant]
US 20140348408A1 · Zhu et al. · 2014 [cited by applicant]
US 20150011902A1 · Wang · 2015 [cited by applicant]
US 20150104102A1 · Carreira et al. · 2015 [cited by applicant]
US 20150208994A1 · Rapoport · 2015 [cited by applicant]
US 20150320365A1 · Schulze et al. · 2015 [cited by applicant]
US 20160012192A1 · Radhakrishnan et al. · 2016 [cited by applicant]
US 20160037057A1 · Westin et al. · 2016 [cited by applicant]
US 20160063191A1 · Vesto et al. · 2016 [cited by applicant]
US 20160100302A1 · Barash et al. · 2016 [cited by applicant]
US 20160110890A1 · Smith · 2016 [cited by applicant]
US 20160135706A1 · Sullivan et al. · 2016 [cited by applicant]
US 20160180042A1 · Menon et al. · 2016 [cited by applicant]
US 20160188829A1 · Southerland et al. · 2016 [cited by applicant]
US 20170007167A1 · Kostic et al. · 2017 [cited by applicant]
US 20170143428A1 · Raffy et al. · 2017 [cited by applicant]
US 20170147765A1 · Mehta · 2017 [cited by applicant]
US 20170181657A1 · Jin et al. · 2017 [cited by applicant]
US 20170228501A1 · Turner et al. · 2017 [cited by applicant]
US 20170228516A1 · Sampath et al. · 2017 [cited by applicant]
US 20170258433A1 · Gulsun et al. · 2017 [cited by applicant]
US 20170300654A1 · Stein et al. · 2017 [cited by applicant]
US 20170340260A1 · Chowdhury et al. · 2017 [cited by applicant]
US 20180025255A1 · Poole et al. · 2018 [cited by applicant]
US 20180046759A1 · Barral · 2018 [cited by applicant]
US 20180085001A1 · Berger et al. · 2018 [cited by applicant]
US 20180110475A1 · Shaya · 2018 [cited by applicant]
US 20180116620A1 · Chen et al. · 2018 [cited by applicant]
US 20180235482A1 · Fonte et al. · 2018 [cited by applicant]
US 20180253530A1 · Goldberg et al. · 2018 [cited by applicant]
US 20180365824A1 · Yuh et al. · 2018 [cited by applicant]
US 20180365828A1 · Mansi et al. · 2018 [cited by applicant]
US 20180366225A1 · Mansi et al. · 2018 [cited by applicant]
US 20190130228A1 · Fu et al. · 2019 [cited by applicant]
US 20190138693A1 · Muller et al. · 2019 [cited by applicant]
US 20190156484A1 · Nye et al. · 2019 [cited by applicant]
US 20190156937A1 · Shimomura et al. · 2019 [cited by applicant]
US 20190198160A1 · Barral · 2019 [cited by applicant]
US 20190380643A1 · Kochura et al. · 2019 [cited by applicant]
US 20200027545A1 · Xie et al. · 2020 [cited by applicant]
US 20200058410A1 · Khouri et al. · 2020 [cited by applicant]
US 20200090331A1 · Mansi et al. · 2020 [cited by applicant]
US 20200279624A1 · Rao et al. · 2020 [cited by applicant]
US 20200294241A1 · Wu et al. · 2020 [cited by applicant]
US 20200359981A1 · Straka et al. · 2020 [cited by applicant]
US 20200364587A1 · Kapur et al. · 2020 [cited by applicant]
US 20200364864A1 · Shanbhag et al. · 2020 [cited by applicant]
US 20210057112A1 · Mansi et al. · 2021 [cited by applicant]
US 20210137384A1 · Robinson et al. · 2021 [cited by applicant]
US 20210193301A1 · Kanan et al. · 2021 [cited by applicant]
US 20210275025A1 · Hickle et al. · 2021 [cited by applicant]
US 20210334958A1 · Siow et al. · 2021 [cited by applicant]
US 20220028524A1 · Levi et al. · 2022 [cited by applicant]
US 20220087631A1 · D'Esterre et al. · 2022 [cited by applicant]
US 20220130547A1 · Grady et al. · 2022 [cited by applicant]
US 20220180518A1 · Agus et al. · 2022 [cited by applicant]
CN 109003299A · 2018 [cited by applicant]
JP 2004243117A · 2004 [cited by applicant]
JP 4854717B2 · 2011 [cited by applicant]
JP 2012027565A · 2012 [cited by applicant]
WO 2016086289A1 · 2016 [cited by applicant]
WO 2016134125A1 · 2016 [cited by applicant]
Examination Report No. 1 for Australian Patent Application No. 2018288766 dated May 22, 2020. [cited by applicant]
Extended EP Search Report for EP Application No. 18821318.5 mailed Dec. 23, 2020. [cited by applicant]
International Search Report and Written Opinion for International Application No. PCT/US2018/038334 mailed Aug. 30, 2018. [cited by applicant]
International Search Report and Written Opinion for PCT Application No. PCT/US20/39903 mailed Sep. 4, 2020. [cited by applicant]
International Search Report and Written Opinion for PCT Application No. PCT/US20/43527 mailed Oct. 16, 2020. [cited by applicant]
Cai, Zhaowei , et al., “Cascade R-CNN: High Quality Object Detection and Instance Segmentation”, https://arxiv.org/pdf/1906.09756.pdf, Jun. 24, 2019. [cited by applicant]
Gupta, Akshat , et al., “Delineation of Ischemic Core and Penumbra Volumes from MRI using MSNet Architecture”, Annu Int Conf IEEE Eng Med Biol Soc. Jul. 2019;2019:6730-6733. [cited by applicant]
He, Kaiming , et al., “Mask R-CNN”, https://arxiv.org/pdf/1703.06870.pdf, Jan. 24, 2018. [cited by applicant]
Ker, Justin , et al., “Image Thresholding Improves 3-Dimensional Convolutional Neural Network 1-21 Diagnosis of Different Acute Brain Hemorrhages on Computed Tomography Scans”, Sensors 2019, 2167,May 10, 2019, www.mdpi.… [cited by applicant]
Keshavamurthy, Krishna , “Machine learning algorithm for automatic detection of CT-identifiable hyperdense lesions associated with traumatic brain injury”, Proc. of SPIE vol. 10134 2017. [cited by applicant]
Keshavamurthy, K. , et al., “Machine learning algorithm for automatic detection of CT-identifiable hyperdense lesions associated with traumatic brain injury”, Mar. 23, 2017, SPIE Medical Imaging, Orlando, Florida. [cited by applicant]
Kirisil, H.A. , et al., “Standardized evaluation framework for evaluating coronary artery stenosis detection, stenosis quantification and lumen segmentation algorithms in computed tomography angiography”, Elsevier, 2013… [cited by applicant]
Kuang, Hulin , et al., “Segmenting Hemorrhagic and Ischemic Infarct Simultaneously From Follow-Up Non-Contrast CT Images in Patients With Acute Ischemic Stroke”, IEEE Access, vol. 7, May 22, 2019. [cited by applicant]
Lewis, Thomas L., et al., “Ambulance smartphone tool for field triage of ruptured aortic aneurysms (FILTR): study protocol for a prospective observational validation of diagnostic accuracy”, BMJ Open 2016, pp. 1-5, http… [cited by applicant]
Lidayova, Kristina , et al., “Skeleton-based 1-3,6-15 fast, fully automated generation of vessel tree structure for clinical evaluation of blood vessel systems”, In: Skeletonization : theory, methods and applications, J… [cited by applicant]
Liu, Liyuan , et al., “On the Variance of the Adaptive Learning Rate and Beyond”, https://arxiv.org/pdf/1908.03265.pdf, Apr. 17, 2020, Published as a conference paper at ICLR 2020. [cited by applicant]
Madhuripan, Nikhil , et al., “Computed Tomography Angiography in Head and Neck Emergencies”, Seminars in Ultrasound and CT and MRI, US, vol. 38, No. 4, 2017. Feb. 20, 2017 (Feb. 20, 2017), pp. 345-356. [cited by applicant]
Mittal, Sushil , et al., “Fast Automatic Detection of Calcified Coronary Lesions in 3D Cardiac CT Images”, MLMI 2010, pp. 1-9. [cited by applicant]
Smith, Wade S., et al., “Prognostic Significance of Angiographically Confirmed Large Vessel Intracranial Occlusion in Patients Presenting With Acute Brain Ischemia”, Neurocritical Care, vol. 4, 2006. [cited by applicant]
Yu, Y. , et al., “Use of Deep Learning to Predict Final Ischemic Stroke Lesions From Initial Magnetic Resonance Imaging”, Mar. 1, 2020, https://europepmc.org/article/med/32163165. [cited by applicant]
Zerna, C. , et al., “Imaging, Intervention, and Workflow in Acute Ischemic Strike: The Calgary Approach”, AJNR M J Neuroradiol 37.978-84, Jun. 2016, pp. 978-984. [cited by applicant]