IP Library › Granted Patent US 12,312,640
Granted Patent B2
US 12,312,640 · App. 18/786,391 · Granted May 27, 2025

Analysis of nucleic acid sequences

Inventors: Benjamin Hindson (Pleasanton, CA); Christopher Hindson (Pleasanton, CA); Michael Schnall-Levin (San Francisco, CA); Kevin Ness (Pleasanton, CA); Mirna Jarosz (Mountain View, CA); Serge Saxonov (Oakland, CA)
Assignee: 10X GENOMICS, INC.
C12Q1/6883C12Q1/6827G16B30/00G16B30/10G16B30/20C12Q2535/122C12Q2600/156
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Quick Facts
Patent No.
US 12,312,640
App. No.
18/786,391
Granted
May 27, 2025
Kind
B2
Abstract

The present disclosure relates to methods, compositions and systems for haplotype phasing and copy number variation assays. Included within this disclosure are methods and systems for combining the barcode comprising beads with samples in multiple separate partitions, as well as methods of processing, sequencing and analyzing barcoded samples.

Claims (37)

1. A method, comprising:

(a) coupling an antibody to a cell feature of a cell, wherein the antibody is associated with a first barcode molecule comprising a first barcode sequence;

(b) providing a second barcode molecule comprising a second barcode sequence;

(c) from the first barcode molecule and the second barcode molecule, generating a barcoded molecule comprising (i) the first barcode sequence or complement thereof, and (ii) the second barcode sequence or complement thereof;

(d) providing an additional barcode molecule comprising the second barcode sequence; and

(e) from a nucleic acid sequence of the cell and the additional barcode molecule, generating an additional barcoded molecule comprising (i) the nucleic acid sequence or complement thereof, and (ii) the second barcode sequence or complement thereof.

2. The method according to claim 1 , wherein the cell feature of the cell is a protein.

3. The method according to claim 2 , wherein the protein is located on an extracellular surface of the cell.

4. The method according to claim 1 , further comprising:

(f) capturing the barcoded molecule or the additional barcoded molecule with an oligonucleotide molecule comprising a capture sequence.

5. The method according to claim 4 , further comprising capturing the barcoded molecule and the additional barcoded molecule with oligonucleotide molecules that comprise identical capture sequences.

6. The method according to claim 5 , wherein the identical capture sequences comprise poly-thymine (poly-T) sequences.

7. The method according to claim 1 , further comprising sequencing the barcoded molecule or derivative thereof and sequencing the additional barcoded molecule or derivative thereof.

8. The method according to claim 1 , further comprising:

(f) identifying the first barcode sequence and the second barcode sequence; and

(g) using the first barcode sequence and the second barcode sequence identified in (f) to identify the cell feature of the cell and identify the cell, respectively.

9. The method according to claim 1 , wherein (c) and (e) are performed simultaneously.

10. The method according to claim 1 , wherein, prior to (c), the cell is placed in a partition comprising the second barcode sequence.

11. The method according to claim 10 , wherein (c) and (e) are performed in the partition.

12. The method according to claim 10 , wherein the partition comprises a ligase or a reverse transcriptase.

13. The method according to claim 10 , wherein the partition is a droplet.

14. The method according to claim 10 , wherein the partition is a well.

15. The method according to claim 14 , wherein the well is a microwell.

16. The method according to claim 1 , further comprising co-partitioning the cell with a bead, wherein the bead comprises the second barcode molecule and the additional barcode molecule.

17. The method according to claim 16 , wherein the bead is a gel bead.

18. The method according to claim 16 , wherein the bead comprises at least 1,000 barcode molecules comprising the second barcode sequence.

19. The method according to claim 1 , further comprising attaching a functional molecule to the barcoded molecule or derivative thereof.

20. The method according to claim 19 , wherein the functional molecule comprises a biotin tag.

21. The method according to claim 19 , wherein the functional molecule comprises a flow cell attachment sequence.

22. The method according to claim 19 , wherein the functional molecule comprises a unique molecular sequence segment.

23. The method according to claim 1 , further comprising ligating a functional molecule to the additional barcode molecule or derivative thereof.

24. The method according to claim 23 , wherein the functional molecule comprises a biotin tag.

25. The method according to claim 23 , wherein the functional molecule comprises a flow cell attachment sequence.

26. The method according to claim 23 , wherein the functional molecule comprises a unique molecular sequence segment.

27. The method according to claim 1 , wherein the nucleic acid sequence is a ribonucleic acid (RNA) sequence.

28. The method according to claim 27 , wherein the RNA sequence is a messenger RNA (mRNA) sequence.

29. The method according to claim 28 , wherein the mRNA sequence comprises a synthetic nucleic acid sequence.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 12, 2025
From: HINDSON, BENJAMIN; HINDSON, CHRISTOPHER; SCHNALL-LEVIN, MICHAEL; NESS, KEVIN; JAROSZ, MIRNA; SAXONOV, SERGE
To: 10X GENOMICS, INC.
Reel/Frame 070196/0104 →
Continuity (13)
Continuation 18207023 · Jun 7, 2023
Continuation 17986764 · Nov 14, 2022
Continuation 17860880 · Jul 8, 2022
Continuation 17538783 · Nov 30, 2021
Continuation 16570898 · Sep 13, 2019
Continuation 16144832 · Sep 27, 2018
Continuation 16045474 · Jul 25, 2018
Continuation 15872499 · Jan 16, 2018
Continuation 15717871 · Sep 27, 2017
Continuation In Part 14752641 · Jun 26, 2015
Provisional Application 62061567 · Oct 8, 2014
Provisional Application 62017558 · Jun 26, 2014
Related Publication 20240384348A1 · Nov 21, 2024
References Cited (400)
US 2797149A · Skeggs · 1957 [cited by applicant]
US 3047367A · Kessler · 1962 [cited by applicant]
US 3479141A · Smythe et al. · 1969 [cited by applicant]
US 4124638A · Hansen · 1978 [cited by applicant]
US 4253846A · Smythe et al. · 1981 [cited by applicant]
US 4582802A · Zimmerman et al. · 1986 [cited by applicant]
US 4804450A · Mochizuki et al. · 1989 [cited by applicant]
US 5137829A · Nag et al. · 1992 [cited by applicant]
US 5149625A · Church et al. · 1992 [cited by applicant]
US 5185099A · Delpuech et al. · 1993 [cited by applicant]
US 5202231A · Drmanac et al. · 1993 [cited by applicant]
US 5270183A · Corbett et al. · 1993 [cited by applicant]
US 5413924A · Kosak et al. · 1995 [cited by applicant]
US 5418149A · Gelfand et al. · 1995 [cited by applicant]
US 5436130A · Mathies et al. · 1995 [cited by applicant]
US 5456986A · Majetich et al. · 1995 [cited by applicant]
US 5478893A · Ghosh et al. · 1995 [cited by applicant]
US 5489523A · Mathur · 1996 [cited by applicant]
US 5512131A · Kumar et al. · 1996 [cited by applicant]
US 5558071A · Ward et al. · 1996 [cited by applicant]
US 5585069A · Zanzucchi et al. · 1996 [cited by applicant]
US 5587128A · Wilding et al. · 1996 [cited by applicant]
US 5605793A · Stemmer et al. · 1997 [cited by applicant]
US 5618711A · Gelfand et al. · 1997 [cited by applicant]
US 5658548A · Padhye et al. · 1997 [cited by applicant]
US 5695940A · Drmanac et al. · 1997 [cited by applicant]
US 5700642A · Monforte et al. · 1997 [cited by applicant]
US 5705628A · Hawkins · 1998 [cited by applicant]
US 5708153A · Dower et al. · 1998 [cited by applicant]
US 5736330A · Fulton · 1998 [cited by applicant]
US 5739036A · Parris · 1998 [cited by applicant]
US 5744311A · Fraiser et al. · 1998 [cited by applicant]
US 5756334A · Perler et al. · 1998 [cited by applicant]
US 5830663A · Embleton et al. · 1998 [cited by applicant]
US 5834197A · Parton · 1998 [cited by applicant]
US 5842787A · Kopf-Sill et al. · 1998 [cited by applicant]
US 5846719A · Brenner et al. · 1998 [cited by applicant]
US 5846727A · Soper et al. · 1998 [cited by applicant]
US 5851769A · Gray et al. · 1998 [cited by applicant]
US 5856174A · Lipshutz et al. · 1999 [cited by applicant]
US 5872010A · Karger et al. · 1999 [cited by applicant]
US 5897783A · Howe et al. · 1999 [cited by applicant]
US 5900481A · Lough et al. · 1999 [cited by applicant]
US 5942609A · Hunkapiller et al. · 1999 [cited by applicant]
US 5958703A · Dower et al. · 1999 [cited by applicant]
US 5965443A · Reznikoff et al. · 1999 [cited by applicant]
US 5994056A · Higuchi · 1999 [cited by applicant]
US 5997636A · Gamarnik et al. · 1999 [cited by applicant]
US 6033880A · Haff et al. · 2000 [cited by applicant]
US 6046003A · Mandecki · 2000 [cited by applicant]
US 6051377A · Mandecki · 2000 [cited by applicant]
US 6057107A · Fulton · 2000 [cited by applicant]
US 6057149A · Burns et al. · 2000 [cited by applicant]
US 6103537A · Ullman et al. · 2000 [cited by applicant]
US 6110678A · Weisburg et al. · 2000 [cited by applicant]
US 6123798A · Gandhi et al. · 2000 [cited by applicant]
US 6133436A · Koester et al. · 2000 [cited by applicant]
US 6143496A · Brown et al. · 2000 [cited by applicant]
US 6159717A · Savakis et al. · 2000 [cited by applicant]
US 6171850B1 · Nagle et al. · 2001 [cited by applicant]
US 6172218B1 · Brenner · 2001 [cited by applicant]
US 6176962B1 · Soane et al. · 2001 [cited by applicant]
US 6207384B1 · Mekalanos et al. · 2001 [cited by applicant]
US 6258571B1 · Chumakov et al. · 2001 [cited by applicant]
US 6265552B1 · Schatz · 2001 [cited by applicant]
US 6291243B1 · Fogarty et al. · 2001 [cited by applicant]
US 6294385B1 · Goryshin et al. · 2001 [cited by applicant]
US 6296020B1 · McNeely et al. · 2001 [cited by applicant]
US 6297006B1 · Drmanac et al. · 2001 [cited by applicant]
US 6297017B1 · Schmidt et al. · 2001 [cited by applicant]
US 6303343B1 · Kopf-Sill · 2001 [cited by applicant]
US 6306590B1 · Mehta et al. · 2001 [cited by applicant]
US 6327410B1 · Walt et al. · 2001 [cited by applicant]
US 6355198B1 · Kim et al. · 2002 [cited by applicant]
US 6361950B1 · Mandecki · 2002 [cited by applicant]
US 6372813B1 · Johnson et al. · 2002 [cited by applicant]
US 6379929B1 · Burns et al. · 2002 [cited by applicant]
US 6406848B1 · Bridgham et al. · 2002 [cited by applicant]
US 6409832B2 · Weigl et al. · 2002 [cited by applicant]
US 6432290B1 · Harrison et al. · 2002 [cited by applicant]
US 6432360B1 · Church · 2002 [cited by applicant]
US 6485944B1 · Church et al. · 2002 [cited by applicant]
US 6492118B1 · Abrams et al. · 2002 [cited by applicant]
US 6511803B1 · Church et al. · 2003 [cited by applicant]
US 6524456B1 · Ramsey et al. · 2003 [cited by applicant]
US 6569631B1 · Pantoliano et al. · 2003 [cited by applicant]
US 6579851B2 · Goeke et al. · 2003 [cited by applicant]
US 6586176B1 · Trnovsky et al. · 2003 [cited by applicant]
US 6593113B1 · Tenkanen et al. · 2003 [cited by applicant]
US 6613752B2 · Kay et al. · 2003 [cited by applicant]
US 6632606B1 · Ullman et al. · 2003 [cited by applicant]
US 6632655B1 · Mehta et al. · 2003 [cited by applicant]
US 6670133B2 · Knapp et al. · 2003 [cited by applicant]
US 6723513B2 · Lexow · 2004 [cited by applicant]
US 6767731B2 · Hannah · 2004 [cited by applicant]
US 6800298B1 · Burdick et al. · 2004 [cited by applicant]
US 6806052B2 · Bridgham et al. · 2004 [cited by applicant]
US 6806058B2 · Jesperson et al. · 2004 [cited by applicant]
US 6859570B2 · Walt et al. · 2005 [cited by applicant]
US 6880576B2 · Karp et al. · 2005 [cited by applicant]
US 6884788B2 · Bulpitt et al. · 2005 [cited by applicant]
US 6913935B1 · Thomas · 2005 [cited by applicant]
US 6915679B2 · Chien et al. · 2005 [cited by applicant]
US 6929859B2 · Chandler et al. · 2005 [cited by applicant]
US 6969488B2 · Bridgham et al. · 2005 [cited by applicant]
US 6974669B2 · Mirkin et al. · 2005 [cited by applicant]
US 7041481B2 · Anderson et al. · 2006 [cited by applicant]
US 7115400B1 · Adessi et al. · 2006 [cited by applicant]
US 7129091B2 · Ismagilov et al. · 2006 [cited by applicant]
US 7138267B1 · Jendrisak et al. · 2006 [cited by applicant]
US 7211654B2 · Gao et al. · 2007 [cited by applicant]
US 7262056B2 · Wooddell et al. · 2007 [cited by applicant]
US 7268167B2 · Higuchi et al. · 2007 [cited by applicant]
US 7282370B2 · Bridgham et al. · 2007 [cited by applicant]
US 7294503B2 · Quake et al. · 2007 [cited by applicant]
US 7297485B2 · Bornarth et al. · 2007 [cited by applicant]
US 7316903B2 · Yanagihara et al. · 2008 [cited by applicant]
US 7323305B2 · Leamon et al. · 2008 [cited by applicant]
US 7329493B2 · Chou et al. · 2008 [cited by applicant]
US 7425431B2 · Church et al. · 2008 [cited by applicant]
US 7536928B2 · Kazuno · 2009 [cited by applicant]
US 7544473B2 · Brenner · 2009 [cited by applicant]
US 7604938B2 · Takahashi et al. · 2009 [cited by applicant]
US 7608434B2 · Reznikoff et al. · 2009 [cited by applicant]
US 7608451B2 · Cooper et al. · 2009 [cited by applicant]
US 7622076B2 · Davies et al. · 2009 [cited by applicant]
US 7622280B2 · Holliger et al. · 2009 [cited by applicant]
US 7638276B2 · Griffiths et al. · 2009 [cited by applicant]
US 7645596B2 · Williams et al. · 2010 [cited by applicant]
US 7666664B2 · Sarofim et al. · 2010 [cited by applicant]
US 7700325B2 · Cantor et al. · 2010 [cited by applicant]
US 7708949B2 · Stone et al. · 2010 [cited by applicant]
US 7709197B2 · Drmanac · 2010 [cited by applicant]
US 7745178B2 · Dong · 2010 [cited by applicant]
US 7745218B2 · Kim et al. · 2010 [cited by applicant]
US 7772287B2 · Higuchi et al. · 2010 [cited by applicant]
US 7776927B2 · Chu et al. · 2010 [cited by applicant]
US RE41780E · Anderson et al. · 2010 [cited by applicant]
US 7799553B2 · Mathies et al. · 2010 [cited by applicant]
US 7842457B2 · Berka et al. · 2010 [cited by applicant]
US 7901891B2 · Drmanac · 2011 [cited by applicant]
US 7910354B2 · Drmanac et al. · 2011 [cited by applicant]
US 7927797B2 · Nobile et al. · 2011 [cited by applicant]
US 7943671B2 · Herminghaus et al. · 2011 [cited by applicant]
US 7947477B2 · Schroeder et al. · 2011 [cited by applicant]
US 7960104B2 · Drmanac et al. · 2011 [cited by applicant]
US 7968287B2 · Griffiths et al. · 2011 [cited by applicant]
US 7972778B2 · Brown et al. · 2011 [cited by applicant]
US 8003312B2 · Krutzik et al. · 2011 [cited by applicant]
US 8008018B2 · Quake et al. · 2011 [cited by applicant]
US 8053192B2 · Bignell et al. · 2011 [cited by applicant]
US 8067159B2 · Brown et al. · 2011 [cited by applicant]
US 8101346B2 · Takahama · 2012 [cited by applicant]
US 8124404B2 · Alphey et al. · 2012 [cited by applicant]
US 8133719B2 · Drmanac et al. · 2012 [cited by applicant]
US 8137563B2 · Ma et al. · 2012 [cited by applicant]
US 8168385B2 · Brenner · 2012 [cited by applicant]
US 8252539B2 · Quake et al. · 2012 [cited by applicant]
US 8268564B2 · Roth et al. · 2012 [cited by applicant]
US 8273573B2 · Ismagilov et al. · 2012 [cited by applicant]
US 8278071B2 · Brown et al. · 2012 [cited by applicant]
US 8298767B2 · Brenner et al. · 2012 [cited by applicant]
US 8304193B2 · Ismagilov et al. · 2012 [cited by applicant]
US 8318433B2 · Brenner · 2012 [cited by applicant]
US 8318460B2 · Cantor et al. · 2012 [cited by applicant]
US 8329407B2 · Ismagilov et al. · 2012 [cited by applicant]
US 8337778B2 · Stone et al. · 2012 [cited by applicant]
US 8361299B2 · Sabin et al. · 2013 [cited by applicant]
US 8420386B2 · Ivics et al. · 2013 [cited by applicant]
US 8461129B2 · Bolduc et al. · 2013 [cited by applicant]
US 8563274B2 · Brenner et al. · 2013 [cited by applicant]
US 8592150B2 · Drmanac et al. · 2013 [cited by applicant]
US 8598328B2 · Koga et al. · 2013 [cited by applicant]
US 8603749B2 · Gillevet · 2013 [cited by applicant]
US 8658430B2 · Miller et al. · 2014 [cited by applicant]
US 8679756B1 · Brenner et al. · 2014 [cited by applicant]
US 8748094B2 · Weitz et al. · 2014 [cited by applicant]
US 8748102B2 · Berka et al. · 2014 [cited by applicant]
US 8765380B2 · Berka et al. · 2014 [cited by applicant]
US 8822148B2 · Ismagliov et al. · 2014 [cited by applicant]
US 8829171B2 · Steemers et al. · 2014 [cited by applicant]
US 8835358B2 · Fodor et al. · 2014 [cited by applicant]
US 8846883B2 · Brown et al. · 2014 [cited by applicant]
US 8871444B2 · Griffiths et al. · 2014 [cited by applicant]
US 8889083B2 · Ismagilov et al. · 2014 [cited by applicant]
US 8927218B2 · Forsyth · 2015 [cited by applicant]
US 8975302B2 · Light et al. · 2015 [cited by applicant]
US 8986628B2 · Stone et al. · 2015 [cited by applicant]
US 9005935B2 · Belyaev · 2015 [cited by applicant]
US 9012370B2 · Hong · 2015 [cited by applicant]
US 9012390B2 · Holtze et al. · 2015 [cited by applicant]
US 9017948B2 · Agresti et al. · 2015 [cited by applicant]
US 9029083B2 · Griffiths et al. · 2015 [cited by applicant]
US 9029085B2 · Agresti et al. · 2015 [cited by applicant]
US 9040256B2 · Grunenwald et al. · 2015 [cited by applicant]
US 9068210B2 · Agresti et al. · 2015 [cited by applicant]
US 9074251B2 · Steemers et al. · 2015 [cited by applicant]
US 9080211B2 · Grunenwald et al. · 2015 [cited by applicant]
US 9085798B2 · Chee · 2015 [cited by applicant]
US 9089844B2 · Hiddessen et al. · 2015 [cited by applicant]
US 9102980B2 · Brenner et al. · 2015 [cited by applicant]
US 9126160B2 · Ness et al. · 2015 [cited by applicant]
US 9133009B2 · Baroud et al. · 2015 [cited by applicant]
US 9150852B2 · Samuels · 2015 [cited by examiner]
US 9150916B2 · Christen et al. · 2015 [cited by applicant]
US 9156010B2 · Colston et al. · 2015 [cited by applicant]
US 9175295B2 · Kaminaka et al. · 2015 [cited by applicant]
US 9194861B2 · Hindson et al. · 2015 [cited by applicant]
US 9216392B2 · Hindson et al. · 2015 [cited by applicant]
US 9222128B2 · Saxonov et al. · 2015 [cited by applicant]
US 9238206B2 · Rotem et al. · 2016 [cited by applicant]
US 9238671B2 · Goryshin et al. · 2016 [cited by applicant]
US 9249460B2 · Pushkarev et al. · 2016 [cited by applicant]
US 9266104B2 · Link · 2016 [cited by applicant]
US 9273349B2 · Nguyen et al. · 2016 [cited by applicant]
US 9290808B2 · Fodor et al. · 2016 [cited by applicant]
US 9328382B2 · Drmanac et al. · 2016 [cited by applicant]
US 9347059B2 · Saxonov · 2016 [cited by applicant]
US 9371598B2 · Chee · 2016 [cited by applicant]
US 9388465B2 · Hindson et al. · 2016 [cited by applicant]
US 9410201B2 · Hindson et al. · 2016 [cited by applicant]
US 9417190B2 · Hindson et al. · 2016 [cited by applicant]
US 9436088B2 · Seul et al. · 2016 [cited by applicant]
US 9486757B2 · Romanowsky et al. · 2016 [cited by applicant]
US 9498761B2 · Holtze et al. · 2016 [cited by applicant]
US 9500664B2 · Ness et al. · 2016 [cited by applicant]
US 9567631B2 · Hindson et al. · 2017 [cited by applicant]
US 9574226B2 · Gormley et al. · 2017 [cited by applicant]
US 9593365B2 · Frisen et al. · 2017 [cited by applicant]
US 9623384B2 · Hindson et al. · 2017 [cited by applicant]
US 9637799B2 · Fan et al. · 2017 [cited by applicant]
US 9644204B2 · Hindson et al. · 2017 [cited by applicant]
US 9689024B2 · Hindson et al. · 2017 [cited by applicant]
US 9694361B2 · Bharadwaj et al. · 2017 [cited by applicant]
US 9695468B2 · Hindson et al. · 2017 [cited by applicant]
US 9701998B2 · Hindson et al. · 2017 [cited by applicant]
US 9764322B2 · Hiddessen et al. · 2017 [cited by applicant]
US 9824068B2 · Wong · 2017 [cited by applicant]
US 9856530B2 · Hindson et al. · 2018 [cited by applicant]
US 9868979B2 · Chee et al. · 2018 [cited by applicant]
US 9879313B2 · Chee et al. · 2018 [cited by applicant]
US 9902950B2 · Church et al. · 2018 [cited by applicant]
US 9946577B1 · Stafford et al. · 2018 [cited by applicant]
US 9951386B2 · Hindson et al. · 2018 [cited by applicant]
US 9957558B2 · Leamon et al. · 2018 [cited by applicant]
US 9975122B2 · Masquelier et al. · 2018 [cited by applicant]
US 10011872B1 · Belgrader et al. · 2018 [cited by applicant]
US 10017759B2 · Kaper et al. · 2018 [cited by applicant]
US 10030261B2 · Frisen et al. · 2018 [cited by applicant]
US 10030267B2 · Hindson et al. · 2018 [cited by applicant]
US 10041116B2 · Hindson et al. · 2018 [cited by applicant]
US 10053723B2 · Hindson et al. · 2018 [cited by applicant]
US 10059989B2 · Giresi et al. · 2018 [cited by applicant]
US 10071377B2 · Bharadwaj et al. · 2018 [cited by applicant]
US 10119167B2 · Srinivasan et al. · 2018 [cited by applicant]
US 10137449B2 · Bharadwaj et al. · 2018 [cited by applicant]
US 10144950B2 · Nolan · 2018 [cited by applicant]
US 10150117B2 · Bharadwaj et al. · 2018 [cited by applicant]
US 10150963B2 · Hindson et al. · 2018 [cited by applicant]
US 10150964B2 · Hindson et al. · 2018 [cited by applicant]
US 10150995B1 · Giresi et al. · 2018 [cited by applicant]
US 10161007B2 · Abate et al. · 2018 [cited by applicant]
US 10167509B2 · Regan et al. · 2019 [cited by applicant]
US 10174310B2 · Nolan · 2019 [cited by applicant]
US 10208343B2 · Hindson et al. · 2019 [cited by applicant]
US 10221436B2 · Hardenbol et al. · 2019 [cited by applicant]
US 10221442B2 · Hindson et al. · 2019 [cited by applicant]
US 10227648B2 · Hindson et al. · 2019 [cited by applicant]
US 10253364B2 · Hindson et al. · 2019 [cited by applicant]
US 10273541B2 · Hindson et al. · 2019 [cited by applicant]
US 10287623B2 · Jarosz et al. · 2019 [cited by applicant]
US 10323278B2 · Belgrader et al. · 2019 [cited by applicant]
US 10323279B2 · Hindson et al. · 2019 [cited by applicant]
US 10337061B2 · Hindson et al. · 2019 [cited by applicant]
US 10344329B2 · Hindson et al. · 2019 [cited by applicant]
US 10347365B2 · Wong et al. · 2019 [cited by applicant]
US 10357771B2 · Bharadwaj et al. · 2019 [cited by applicant]
US 10395758B2 · Schnall-Levin · 2019 [cited by applicant]
US 10400280B2 · Hindson et al. · 2019 [cited by applicant]
US 10428326B2 · Belhocine et al. · 2019 [cited by applicant]
US 10450607B2 · Hindson et al. · 2019 [cited by applicant]
US 10457986B2 · Hindson et al. · 2019 [cited by applicant]
US 10480028B2 · Hindson et al. · 2019 [cited by applicant]
US 10480029B2 · Bent et al. · 2019 [cited by applicant]
US 10533221B2 · Hindson et al. · 2020 [cited by applicant]
US 10544413B2 · Bharadwaj et al. · 2020 [cited by applicant]
US 10549279B2 · Bharadwaj et al. · 2020 [cited by applicant]
US 10557158B2 · Hardenbol et al. · 2020 [cited by applicant]
US 10584381B2 · Hindson et al. · 2020 [cited by applicant]
US 10590244B2 · Delaney et al. · 2020 [cited by applicant]
US 10597718B2 · Hindson et al. · 2020 [cited by applicant]
US 10612090B2 · Hindson et al. · 2020 [cited by applicant]
US 10626458B2 · Hindson et al. · 2020 [cited by applicant]
US 10669583B2 · Hindson et al. · 2020 [cited by applicant]
US 10676789B2 · Hindson et al. · 2020 [cited by applicant]
US 10697008B2 · Blauwkamp et al. · 2020 [cited by applicant]
US 10745742B2 · Bent et al. · 2020 [cited by applicant]
US 10752949B2 · Hindson et al. · 2020 [cited by applicant]
US 10752950B2 · Hindson et al. · 2020 [cited by applicant]
US 10760124B2 · Hindson et al. · 2020 [cited by applicant]
US 10774374B2 · Frisen et al. · 2020 [cited by applicant]
US 10793905B2 · Bent et al. · 2020 [cited by applicant]
US 10815525B2 · Lucero et al. · 2020 [cited by applicant]
US 10829815B2 · Bharadwaj et al. · 2020 [cited by applicant]
US 10837047B2 · Delaney et al. · 2020 [cited by applicant]
US 10874997B2 · Weitz et al. · 2020 [cited by applicant]
US 10876147B2 · Bent et al. · 2020 [cited by applicant]
US 10995333B2 · Pfeiffer · 2021 [cited by applicant]
US 11021749B2 · Hindson et al. · 2021 [cited by applicant]
US 11035002B2 · Hindson et al. · 2021 [cited by applicant]
US 11078522B2 · Hindson et al. · 2021 [cited by applicant]
US 11193121B2 · Hindson et al. · 2021 [cited by applicant]
US 11359239B2 · Hindson et al. · 2022 [cited by applicant]
US 11421274B2 · Hindson et al. · 2022 [cited by applicant]
US 11441179B2 · Hindson et al. · 2022 [cited by applicant]
US 11459607B1 · Terry et al. · 2022 [cited by applicant]
US 11467153B2 · Belhocine et al. · 2022 [cited by applicant]
US 11473138B2 · Hindson et al. · 2022 [cited by applicant]
US 12037634B2 · Hindson et al. · 2024 [cited by applicant]
US 12065688B2 · Bell · 2024 [cited by applicant]
US 12084715B1 · Lund · 2024 [cited by applicant]
US 12163179B2 · Bell et al. · 2024 [cited by applicant]
US 12169198B2 · Price et al. · 2024 [cited by applicant]
US 12188014B1 · Price et al. · 2025 [cited by applicant]
US 12235262B1 · Giresi · 2025 [cited by applicant]
US 20010020588A1 · Adourian et al. · 2001 [cited by applicant]
US 20010036669A1 · Jedrzejewski et al. · 2001 [cited by applicant]
US 20010041357A1 · Fouillet et al. · 2001 [cited by applicant]
US 20010044109A1 · Mandecki · 2001 [cited by applicant]
US 20010048900A1 · Bardell et al. · 2001 [cited by applicant]
US 20010051348A1 · Lee · 2001 [cited by applicant]
US 20010053519A1 · Fodor et al. · 2001 [cited by applicant]
US 20020001856A1 · Chow et al. · 2002 [cited by applicant]
US 20020005354A1 · Spence et al. · 2002 [cited by applicant]
US 20020034737A1 · Drmanac · 2002 [cited by applicant]
US 20020043463A1 · Shenderov · 2002 [cited by applicant]
US 20020051971A1 · Stuelpnagel et al. · 2002 [cited by applicant]
US 20020051992A1 · Bridgham et al. · 2002 [cited by applicant]
US 20020065609A1 · Ashby · 2002 [cited by applicant]
US 20020068278A1 · Giese et al. · 2002 [cited by applicant]
US 20020089100A1 · Kawasaki · 2002 [cited by applicant]
US 20020092767A1 · Bjornson et al. · 2002 [cited by applicant]
US 20020113009A1 · O'Connor et al. · 2002 [cited by applicant]
US 20020119455A1 · Chan · 2002 [cited by applicant]
US 20020119536A1 · Stern · 2002 [cited by applicant]
US 20020119544A1 · Yan et al. · 2002 [cited by applicant]
US 20020127736A1 · Chou et al. · 2002 [cited by applicant]
US 20020131147A1 · Paolini et al. · 2002 [cited by applicant]
US 20020160518A1 · Hayenga et al. · 2002 [cited by applicant]
US 20020164820A1 · Brown · 2002 [cited by applicant]
US 20020166582A1 · O'Connor et al. · 2002 [cited by applicant]
US 20020172965A1 · Kamb et al. · 2002 [cited by applicant]
US 20020175079A1 · Christel et al. · 2002 [cited by applicant]
US 20020179849A1 · Maher et al. · 2002 [cited by applicant]
US 20030005967A1 · Karp · 2003 [cited by applicant]
US 20030007898A1 · Bohm et al. · 2003 [cited by applicant]
US 20030008285A1 · Fischer · 2003 [cited by applicant]
US 20030008323A1 · Ravkin et al. · 2003 [cited by applicant]
US 20030022231A1 · Wangh et al. · 2003 [cited by applicant]
US 20030027203A1 · Fields · 2003 [cited by applicant]
US 20030027214A1 · Kamb · 2003 [cited by applicant]
US 20030027221A1 · Scott et al. · 2003 [cited by applicant]
US 20030028981A1 · Chandler et al. · 2003 [cited by applicant]
US 20030032141A1 · Nguyen et al. · 2003 [cited by applicant]
US 20030036206A1 · Chien et al. · 2003 [cited by applicant]
US 20030044777A1 · Beattie · 2003 [cited by applicant]
US 20030044836A1 · Levine et al. · 2003 [cited by applicant]
US 20030075446A1 · Culbertson et al. · 2003 [cited by applicant]
US 20030082587A1 · Seul et al. · 2003 [cited by applicant]
US 20030089605A1 · Timperman · 2003 [cited by applicant]
US 20030104466A1 · Knapp et al. · 2003 [cited by applicant]
US 20030108897A1 · Drmanac · 2003 [cited by applicant]
US 20030124509A1 · Kenis et al. · 2003 [cited by applicant]
US 20030148335A1 · Shen et al. · 2003 [cited by applicant]
US 20030149307A1 · Hai et al. · 2003 [cited by applicant]
US 20030170698A1 · Gascoyne et al. · 2003 [cited by applicant]
US 20030182068A1 · Battersby et al. · 2003 [cited by applicant]
US 20030207260A1 · Trnovsky et al. · 2003 [cited by applicant]
US 20030215862A1 · Parce et al. · 2003 [cited by applicant]
US 20040037813A1 · Simpson et al. · 2004 [cited by applicant]
US 20040040851A1 · Karger et al. · 2004 [cited by applicant]
US 20040063138A1 · McGinnis et al. · 2004 [cited by applicant]
US 20040081962A1 · Chen et al. · 2004 [cited by applicant]
US 20040101680A1 · Barber, Jr. · 2004 [cited by applicant]
US 20040101880A1 · Rozwadowski et al. · 2004 [cited by applicant]
US 20040132122A1 · Banerjee et al. · 2004 [cited by applicant]
US 20040185484A1 · Costa et al. · 2004 [cited by applicant]
US 20040195728A1 · Slomski et al. · 2004 [cited by applicant]
US 20040214175A9 · McKernan et al. · 2004 [cited by applicant]
US 20040224331A1 · Cantor et al. · 2004 [cited by applicant]
US 20040258701A1 · Dominowski et al. · 2004 [cited by applicant]
US 20050019839A1 · Jespersen et al. · 2005 [cited by applicant]
US 20050037397A1 · Mirkin et al. · 2005 [cited by applicant]
US 20050042625A1 · Schmidt et al. · 2005 [cited by applicant]
US 20050130188A1 · Walt et al. · 2005 [cited by applicant]
US 20050136417A1 · Cole et al. · 2005 [cited by applicant]
US 20050181379A1 · Su et al. · 2005 [cited by applicant]
US 20050202429A1 · Trau et al. · 2005 [cited by applicant]
US 20050202489A1 · Cho et al. · 2005 [cited by applicant]
US 20050221339A1 · Griffiths et al. · 2005 [cited by applicant]