IP Library › Granted Patent US 12,235,262
Granted Patent B1
US 12,235,262 · App. 17/014,909 · Granted Feb 25, 2025

Methods and systems for single cell protein analysis

Inventor: Paul Giresi (Palo Alto, CA)
Assignee: 10X GENOMICS, INC.
G01N33/54306G01N33/6842
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,235,262
App. No.
17/014,909
Granted
Feb 25, 2025
Kind
B1
Abstract

Provided herein are methods identifying protein-protein interactions in a single cell context. In some cases, the methods may be used to measure the abundance of protein-protein interactions in a single cell context. In some cases, the methods may be used to map relationships (e.g., spatial relationships) between proteins in a single cell context. Generally, the methods employ the use of proximity probes coupled with splint oligonucleotides to link information about the relationship of proteins within a single cell context, which may then be read in a downstream process (e.g., a sequencing reaction).

Claims (20)

1. A method for processing a labelled cell, comprising:

(a) partitioning a plurality of labelled cells into a plurality of partitions, wherein a partition of the plurality of partitions comprises a cell barcode molecule and a labelled cell of the plurality of labelled cells, wherein the labelled cell comprises (i) a first labelling agent coupled to a first protein of the labelled cell, and (ii) a second labelling agent coupled to a second protein of the labelled cell, wherein the first labelling agent comprises a first proximity probe comprising a first barcode sequence and a first unique molecular identifier (UMI), wherein the second labelling agent comprises a second proximity probe comprising a second barcode sequence and a second UMI, and wherein the cell barcode molecule comprises a third UMI and a cell barcode sequence that is complementary to the first and second barcode sequences; and

(b) generating a barcoded molecule in the partition, wherein the barcoded molecule comprises the first barcode sequence, the first UMI, the second barcode sequence, the second UMI, the third UMI, and the cell barcode sequence, or derivatives thereof.

2. The method of claim 1 , wherein the first protein is a surface protein.

3. The method of claim 1 , wherein the second protein is a surface protein.

4. The method of claim 1 , wherein (a) further comprises partitioning in the partition a support comprising the cell barcode molecule.

5. The method of claim 4 , wherein the support comprises a plurality of cell barcode molecules comprising the cell barcode molecule attached thereto.

6. The method of claim 5 , wherein cell barcode molecules of the plurality of cell barcode molecules comprise the cell barcode sequence.

7. The method of claim 1 , wherein the labelled cell is a single labelled cell and the cell barcode sequence is specific to the single labelled cell.

8. The method of claim 4 , wherein the cell barcode molecule is releasably attached to the support.

9. The method of claim 1 , wherein the partition is a droplet.

10. The method of claim 1 , wherein the partition is a well.

11. The method of claim 1 , wherein the first protein is an internal protein.

12. The method of claim 1 , wherein the second protein is an internal protein.

13. The method of claim 1 , wherein the first barcode sequence comprises a barcode sequence corresponding to a type of the first labelling agent or a type of the first protein.

14. The method of claim 1 , wherein the first labelling agent comprises at least one additional proximity probe, wherein the at least one additional proximity probe comprises a donor probe comprising a donor sequence or an acceptor probe comprising an acceptor sequence.

15. The method of claim 1 , wherein the first proximity probe is:

(a) single stranded; or

(b) single stranded and comprises a donor sequence or an acceptor sequence at an end of the first proximity probe, wherein the cell barcode molecule comprises a first attachment sequence complementary to the donor sequence and a second attachment sequence complementary to the acceptor sequence.

16. The method of claim 1 , wherein the cell barcode molecule comprises a first single stranded portion, a double stranded portion, and a second single stranded portion, wherein the first single stranded portion and the second single stranded portion flank the double stranded portion, wherein the first single stranded portion comprises a first attachment sequence complementary to a donor sequence of the first proximity probe, and wherein the second single stranded portion comprises a second attachment sequence complementary to an acceptor sequence of the second proximity probe.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 18, 2021
From: GIRESI, PAUL
To: 10X GENOMICS, INC.
Reel/Frame 056280/0602 →
Continuity (1)
Provisional Application 62897698 · Sep 9, 2019
References Cited (400)
US 4124638A · Hansen · 1978 [cited by applicant]
US 5185099A · Delpuech et al. · 1993 [cited by applicant]
US 5270183A · Corbett et al. · 1993 [cited by applicant]
US 5478893A · Ghosh et al. · 1995 [cited by applicant]
US 5641870A · Rinderknecht et al. · 1997 [cited by applicant]
US 5736330A · Fulton · 1998 [cited by applicant]
US 5756334A · Perler et al. · 1998 [cited by applicant]
US 5846719A · Brenner et al. · 1998 [cited by applicant]
US 5900481A · Lough et al. · 1999 [cited by applicant]
US 5942609A · Hunkapiller et al. · 1999 [cited by applicant]
US 5994056A · Higuchi · 1999 [cited by applicant]
US 6033880A · Haff et al. · 2000 [cited by applicant]
US 6057149A · Burns et al. · 2000 [cited by applicant]
US 6123798A · Gandhi et al. · 2000 [cited by applicant]
US 6171850B1 · Nagle et al. · 2001 [cited by applicant]
US 6172218B1 · Brenner · 2001 [cited by applicant]
US 6176962B1 · Soane et al. · 2001 [cited by applicant]
US 6306590B1 · Mehta et al. · 2001 [cited by applicant]
US 6327410B1 · Walt et al. · 2001 [cited by applicant]
US 6379929B1 · Burns et al. · 2002 [cited by applicant]
US 6406848B1 · Bridgham et al. · 2002 [cited by applicant]
US 6409832B2 · Weigl et al. · 2002 [cited by applicant]
US 6492118B1 · Abrams et al. · 2002 [cited by applicant]
US 6524456B1 · Ramsey et al. · 2003 [cited by applicant]
US 6586176B1 · Trnovsky et al. · 2003 [cited by applicant]
US 6632655B1 · Mehta et al. · 2003 [cited by applicant]
US 6806058B2 · Jesperson et al. · 2004 [cited by applicant]
US 6890741B2 · Fan et al. · 2005 [cited by applicant]
US 6915679B2 · Chien et al. · 2005 [cited by applicant]
US 7041481B2 · Anderson et al. · 2006 [cited by applicant]
US 7115400B1 · Adessi et al. · 2006 [cited by applicant]
US 7129091B2 · Ismagilov et al. · 2006 [cited by applicant]
US 7268167B2 · Higuchi et al. · 2007 [cited by applicant]
US 7282370B2 · Bridgham et al. · 2007 [cited by applicant]
US 7294503B2 · Quake et al. · 2007 [cited by applicant]
US 7323305B2 · Leamon et al. · 2008 [cited by applicant]
US 7544473B2 · Brenner · 2009 [cited by applicant]
US 7622076B2 · Davies et al. · 2009 [cited by applicant]
US 7622280B2 · Holliger et al. · 2009 [cited by applicant]
US 7638276B2 · Griffiths et al. · 2009 [cited by applicant]
US 7645596B2 · Williams et al. · 2010 [cited by applicant]
US 7708949B2 · Stone et al. · 2010 [cited by applicant]
US 7772287B2 · Higuchi et al. · 2010 [cited by applicant]
US 7776927B2 · Chu et al. · 2010 [cited by applicant]
US 7842457B2 · Berka et al. · 2010 [cited by applicant]
US 7910354B2 · Drmanac et al. · 2011 [cited by applicant]
US 7927797B2 · Nobile et al. · 2011 [cited by applicant]
US 7960104B2 · Drmanac et al. · 2011 [cited by applicant]
US 7968287B2 · Griffiths et al. · 2011 [cited by applicant]
US 8003312B2 · Krutzik et al. · 2011 [cited by applicant]
US 8053192B2 · Bignell et al. · 2011 [cited by applicant]
US 8133719B2 · Drmanac et al. · 2012 [cited by applicant]
US 8168385B2 · Brenner · 2012 [cited by applicant]
US 8268564B2 · Roth et al. · 2012 [cited by applicant]
US 8273573B2 · Ismagilov et al. · 2012 [cited by applicant]
US 8298767B2 · Brenner et al. · 2012 [cited by applicant]
US 8304193B2 · Ismagilov et al. · 2012 [cited by applicant]
US 8318433B2 · Brenner · 2012 [cited by applicant]
US 8329407B2 · Ismagilov et al. · 2012 [cited by applicant]
US 8592150B2 · Drmanac et al. · 2013 [cited by applicant]
US 8658430B2 · Miller et al. · 2014 [cited by applicant]
US 8822148B2 · Ismagliov et al. · 2014 [cited by applicant]
US 8835358B2 · Fodor et al. · 2014 [cited by applicant]
US 8871444B2 · Griffiths et al. · 2014 [cited by applicant]
US 8889083B2 · Ismagilov et al. · 2014 [cited by applicant]
US 8975302B2 · Light et al. · 2015 [cited by applicant]
US 9012390B2 · Holtze et al. · 2015 [cited by applicant]
US 9029083B2 · Griffiths et al. · 2015 [cited by applicant]
US 9029085B2 · Agresti et al. · 2015 [cited by applicant]
US 9085798B2 · Chee · 2015 [cited by applicant]
US 9089844B2 · Hiddessen et al. · 2015 [cited by applicant]
US 9126160B2 · Ness et al. · 2015 [cited by applicant]
US 9156010B2 · Colston et al. · 2015 [cited by applicant]
US 9194861B2 · Hindson et al. · 2015 [cited by applicant]
US 9216392B2 · Hindson et al. · 2015 [cited by applicant]
US 9238206B2 · Rotem et al. · 2016 [cited by applicant]
US 9266104B2 · Link · 2016 [cited by applicant]
US 9290808B2 · Fodor et al. · 2016 [cited by applicant]
US 9328382B2 · Drmanac et al. · 2016 [cited by applicant]
US 9347059B2 · Saxonov · 2016 [cited by applicant]
US 9371598B2 · Chee · 2016 [cited by applicant]
US 9388465B2 · Hindson et al. · 2016 [cited by applicant]
US 9417190B2 · Hindson et al. · 2016 [cited by applicant]
US 9486757B2 · Romanowsky et al. · 2016 [cited by applicant]
US 9498761B2 · Holtze et al. · 2016 [cited by applicant]
US 9500664B2 · Ness et al. · 2016 [cited by applicant]
US 9567631B2 · Hindson et al. · 2017 [cited by applicant]
US 9593365B2 · Frisen et al. · 2017 [cited by applicant]
US 9623384B2 · Hindson et al. · 2017 [cited by applicant]
US 9637799B2 · Fan et al. · 2017 [cited by applicant]
US 9644204B2 · Hindson et al. · 2017 [cited by applicant]
US 9650407B2 · Gartner et al. · 2017 [cited by applicant]
US 9689024B2 · Hindson et al. · 2017 [cited by applicant]
US 9694361B2 · Bharadwaj et al. · 2017 [cited by applicant]
US 9701998B2 · Hindson et al. · 2017 [cited by applicant]
US 9764322B2 · Hiddessen et al. · 2017 [cited by applicant]
US 9824068B2 · Wong · 2017 [cited by applicant]
US 9868979B2 · Chee et al. · 2018 [cited by applicant]
US 9879313B2 · Chee et al. · 2018 [cited by applicant]
US 9946577B1 · Stafford et al. · 2018 [cited by applicant]
US 9951386B2 · Hindson et al. · 2018 [cited by applicant]
US 9957558B2 · Leamon et al. · 2018 [cited by applicant]
US 9975122B2 · Masquelier et al. · 2018 [cited by applicant]
US 10011872B1 · Belgrader et al. · 2018 [cited by applicant]
US 10017759B2 · Kaper et al. · 2018 [cited by applicant]
US 10030261B2 · Frisen et al. · 2018 [cited by applicant]
US 10059989B2 · Giresi et al. · 2018 [cited by applicant]
US 10144950B2 · Nolan · 2018 [cited by applicant]
US 10151003B2 · Fan et al. · 2018 [cited by applicant]
US 10221436B2 · Hardenbol et al. · 2019 [cited by applicant]
US 10221442B2 · Hindson et al. · 2019 [cited by applicant]
US 10253364B2 · Hindson et al. · 2019 [cited by applicant]
US 10273541B2 · Hindson et al. · 2019 [cited by applicant]
US 10323279B2 · Hindson et al. · 2019 [cited by applicant]
US 10338066B2 · Fan et al. · 2019 [cited by applicant]
US 10347365B2 · Wong et al. · 2019 [cited by applicant]
US 10357771B2 · Bharadwaj et al. · 2019 [cited by applicant]
US 10395758B2 · Schnall-Levin · 2019 [cited by applicant]
US 10400280B2 · Hindson et al. · 2019 [cited by applicant]
US 10428326B2 · Belhocine et al. · 2019 [cited by applicant]
US 10533221B2 · Hindson et al. · 2020 [cited by applicant]
US 10544413B2 · Bharadwaj et al. · 2020 [cited by applicant]
US 10549279B2 · Bharadwaj et al. · 2020 [cited by applicant]
US 10557158B2 · Hardenbol et al. · 2020 [cited by applicant]
US 10590244B2 · Delaney et al. · 2020 [cited by applicant]
US 10633691B2 · Wu · 2020 [cited by applicant]
US 10697008B2 · Blauwkamp et al. · 2020 [cited by applicant]
US 10745742B2 · Bent et al. · 2020 [cited by applicant]
US 10752949B2 · Hindson et al. · 2020 [cited by applicant]
US 10774374B2 · Frisen et al. · 2020 [cited by applicant]
US 10815525B2 · Lucero et al. · 2020 [cited by applicant]
US 10829815B2 · Bharadwaj et al. · 2020 [cited by applicant]
US 10837047B2 · Delaney et al. · 2020 [cited by applicant]
US 10874997B2 · Weitz et al. · 2020 [cited by applicant]
US 10995333B2 · Pfeiffer · 2021 [cited by applicant]
US 11371094B2 · Ryvkin et al. · 2022 [cited by applicant]
US 11459607B1 · Terry et al. · 2022 [cited by applicant]
US 11467153B2 · Belhocine et al. · 2022 [cited by applicant]
US 11655499B1 · Pfeiffer · 2023 [cited by applicant]
US 11845983B1 · Belhocine et al. · 2023 [cited by applicant]
US 11851683B1 · Maheshwari et al. · 2023 [cited by applicant]
US 11851700B1 · Bava et al. · 2023 [cited by applicant]
US 11952626B2 · Pfeiffer et al. · 2024 [cited by applicant]
US 20020005354A1 · Spence et al. · 2002 [cited by applicant]
US 20020051971A1 · Stuelpnagel et al. · 2002 [cited by applicant]
US 20020092767A1 · Bjornson et al. · 2002 [cited by applicant]
US 20020119455A1 · Chan · 2002 [cited by applicant]
US 20020127736A1 · Chou et al. · 2002 [cited by applicant]
US 20030027214A1 · Kamb · 2003 [cited by applicant]
US 20030036206A1 · Chien et al. · 2003 [cited by applicant]
US 20030075446A1 · Culbertson et al. · 2003 [cited by applicant]
US 20030082587A1 · Seul et al. · 2003 [cited by applicant]
US 20030089605A1 · Timperman · 2003 [cited by applicant]
US 20030124509A1 · Kenis et al. · 2003 [cited by applicant]
US 20030215862A1 · Parce et al. · 2003 [cited by applicant]
US 20040068019A1 · Higuchi et al. · 2004 [cited by applicant]
US 20050019839A1 · Jespersen et al. · 2005 [cited by applicant]
US 20050037397A1 · Mirkin et al. · 2005 [cited by applicant]
US 20050130188A1 · Walt et al. · 2005 [cited by applicant]
US 20050250147A1 · Macevicz · 2005 [cited by applicant]
US 20050266582A1 · Modlin et al. · 2005 [cited by applicant]
US 20050287572A1 · Mathies et al. · 2005 [cited by applicant]
US 20060177832A1 · Brenner · 2006 [cited by applicant]
US 20060275782A1 · Gunderson et al. · 2006 [cited by applicant]
US 20070020640A1 · McCloskey et al. · 2007 [cited by applicant]
US 20070042419A1 · Barany et al. · 2007 [cited by applicant]
US 20070172873A1 · Brenner et al. · 2007 [cited by applicant]
US 20070190543A1 · Livak · 2007 [cited by applicant]
US 20070196397A1 · Torii et al. · 2007 [cited by applicant]
US 20070264320A1 · Lee et al. · 2007 [cited by applicant]
US 20080056948A1 · Dale et al. · 2008 [cited by applicant]
US 20080166720A1 · Hsieh et al. · 2008 [cited by applicant]
US 20080242560A1 · Gunderson et al. · 2008 [cited by applicant]
US 20090011943A1 · Drmanac et al. · 2009 [cited by applicant]
US 20090047713A1 · Handique · 2009 [cited by applicant]
US 20090099041A1 · Church et al. · 2009 [cited by applicant]
US 20090131543A1 · Weitz et al. · 2009 [cited by applicant]
US 20090148961A1 · Luchini et al. · 2009 [cited by applicant]
US 20090155563A1 · Petsev et al. · 2009 [cited by applicant]
US 20090202984A1 · Cantor · 2009 [cited by applicant]
US 20090235990A1 · Beer · 2009 [cited by applicant]
US 20090269248A1 · Falb et al. · 2009 [cited by applicant]
US 20090286687A1 · Dressman et al. · 2009 [cited by applicant]
US 20100035254A1 · Williams · 2010 [cited by applicant]
US 20100069263A1 · Shendure et al. · 2010 [cited by applicant]
US 20100086914A1 · Bentley et al. · 2010 [cited by applicant]
US 20100105112A1 · Holtze et al. · 2010 [cited by applicant]
US 20100105866A1 · Fraden et al. · 2010 [cited by applicant]
US 20100184928A1 · Kumacheva · 2010 [cited by applicant]
US 20100216153A1 · Lapidus et al. · 2010 [cited by applicant]
US 20100248991A1 · Roesler et al. · 2010 [cited by applicant]
US 20100304982A1 · Hinz et al. · 2010 [cited by applicant]
US 20110217736A1 · Hindson · 2011 [cited by applicant]
US 20110263457A1 · Krutzik et al. · 2011 [cited by applicant]
US 20110305761A1 · Shum et al. · 2011 [cited by applicant]
US 20120071331A1 · Casbon et al. · 2012 [cited by applicant]
US 20120172259A1 · Rigatti et al. · 2012 [cited by applicant]
US 20120196288A1 · Beer · 2012 [cited by applicant]
US 20120219947A1 · Yurkovetsky et al. · 2012 [cited by applicant]
US 20130028812A1 · Prieto et al. · 2013 [cited by applicant]
US 20130109575A1 · Kleinschmidt et al. · 2013 [cited by applicant]
US 20140065234A1 · Shum et al. · 2014 [cited by applicant]
US 20140155295A1 · Hindson et al. · 2014 [cited by applicant]
US 20140170653A1 · Ying · 2014 [cited by applicant]
US 20140221239A1 · Carman et al. · 2014 [cited by applicant]
US 20140242664A1 · Zhang et al. · 2014 [cited by applicant]
US 20140272996A1 · Bemis · 2014 [cited by applicant]
US 20140274740A1 · Srinivasan et al. · 2014 [cited by applicant]
US 20140302503A1 · Lowe et al. · 2014 [cited by applicant]
US 20140338753A1 · Sperling et al. · 2014 [cited by applicant]
US 20140378345A1 · Hindson et al. · 2014 [cited by applicant]
US 20150005188A1 · Levner et al. · 2015 [cited by applicant]
US 20150267191A1 · Steelman et al. · 2015 [cited by applicant]
US 20150361418A1 · Reed · 2015 [cited by applicant]
US 20150376605A1 · Jarosz et al. · 2015 [cited by applicant]
US 20150376609A1 · Hindson et al. · 2015 [cited by applicant]
US 20150376700A1 · Schnall-Levin et al. · 2015 [cited by applicant]
US 20150379196A1 · Schnall-Levin et al. · 2015 [cited by applicant]
US 20160008778A1 · Weitz et al. · 2016 [cited by applicant]
US 20160024558A1 · Hardenbol et al. · 2016 [cited by applicant]
US 20160024572A1 · Shishkin et al. · 2016 [cited by applicant]
US 20160053253A1 · Salathia et al. · 2016 [cited by applicant]
US 20160059204A1 · Hindson et al. · 2016 [cited by applicant]
US 20160060621A1 · Agresti et al. · 2016 [cited by applicant]
US 20160122753A1 · Mikkelsen et al. · 2016 [cited by applicant]
US 20160122817A1 · Jarosz et al. · 2016 [cited by applicant]
US 20160153005A1 · Zhang et al. · 2016 [cited by applicant]
US 20160201125A1 · Samuels et al. · 2016 [cited by applicant]
US 20160203196A1 · Schnall-Levin et al. · 2016 [cited by applicant]
US 20160232291A1 · Kyriazopoulou-Panagiotopoulou et al. · 2016 [cited by applicant]
US 20160244809A1 · Belgrader et al. · 2016 [cited by applicant]
US 20160244828A1 · Mason · 2016 [cited by applicant]
US 20160281160A1 · Jarosz et al. · 2016 [cited by applicant]
US 20160289669A1 · Fan et al. · 2016 [cited by applicant]
US 20160289769A1 · Schwartz et al. · 2016 [cited by applicant]
US 20160314242A1 · Schnall-Levin et al. · 2016 [cited by applicant]
US 20160348093A1 · Price et al. · 2016 [cited by applicant]
US 20170009274A1 · Abate et al. · 2017 [cited by applicant]
US 20170016041A1 · Greenfield et al. · 2017 [cited by applicant]
US 20170128937A1 · Hung et al. · 2017 [cited by applicant]
US 20170144161A1 · Hindson et al. · 2017 [cited by applicant]
US 20170145476A1 · Ryvkin et al. · 2017 [cited by applicant]
US 20170159109A1 · Zheng et al. · 2017 [cited by applicant]
US 20170235876A1 · Jaffe et al. · 2017 [cited by applicant]
US 20170260584A1 · Zheng et al. · 2017 [cited by applicant]
US 20180030515A1 · Regev et al. · 2018 [cited by applicant]
US 20180071695A1 · Weitz et al. · 2018 [cited by applicant]
US 20180080021A1 · Reuter et al. · 2018 [cited by applicant]
US 20180080075A1 · Brenner et al. · 2018 [cited by applicant]
US 20180105808A1 · Mikkelsen et al. · 2018 [cited by applicant]
US 20180112212A1 · Nicol et al. · 2018 [cited by applicant]
US 20180208975A1 · Peterson et al. · 2018 [cited by applicant]
US 20180251825A1 · Stoeckius et al. · 2018 [cited by applicant]
US 20180273933A1 · Gunderson et al. · 2018 [cited by applicant]
US 20180312822A1 · Lee et al. · 2018 [cited by applicant]
US 20180312873A1 · Zheng · 2018 [cited by applicant]
US 20180320224A1 · Gaublomme et al. · 2018 [cited by applicant]
US 20180340169A1 · Belhocine et al. · 2018 [cited by applicant]
US 20180371538A1 · Blauwkamp et al. · 2018 [cited by applicant]
US 20180371545A1 · Wong et al. · 2018 [cited by applicant]
US 20190040382A1 · Steemers et al. · 2019 [cited by applicant]
US 20190060890A1 · Bharadwaj et al. · 2019 [cited by applicant]
US 20190060905A1 · Bharadwaj et al. · 2019 [cited by applicant]
US 20190064173A1 · Bharadwaj et al. · 2019 [cited by applicant]
US 20190071656A1 · Chang et al. · 2019 [cited by applicant]
US 20190100632A1 · Delaney et al. · 2019 [cited by applicant]
US 20190127731A1 · McDermott · 2019 [cited by applicant]
US 20190134633A1 · Bharadwaj et al. · 2019 [cited by applicant]
US 20190136316A1 · Hindson et al. · 2019 [cited by applicant]
US 20190153532A1 · Bharadwaj et al. · 2019 [cited by applicant]
US 20190176152A1 · Bharadwaj et al. · 2019 [cited by applicant]
US 20190177800A1 · Boutet et al. · 2019 [cited by applicant]
US 20190249248A1 · Beechem · 2019 [cited by examiner]
US 20190276818A1 · Gehring et al. · 2019 [cited by applicant]
US 20190323088A1 · Boutet et al. · 2019 [cited by applicant]
US 20190345636A1 · McDermott et al. · 2019 [cited by applicant]
US 20190352717A1 · Schnall-Levin · 2019 [cited by applicant]
US 20190367997A1 · Bent et al. · 2019 [cited by applicant]
US 20190376118A1 · Belhocine et al. · 2019 [cited by applicant]
US 20200002763A1 · Belgrader et al. · 2020 [cited by applicant]
US 20200005902A1 · Mellen et al. · 2020 [cited by applicant]
US 20200032335A1 · Alvarado Martinez · 2020 [cited by applicant]
US 20200033237A1 · Hindson et al. · 2020 [cited by applicant]
US 20200033366A1 · Alvarado Martinez · 2020 [cited by applicant]
US 20200056223A1 · Bell · 2020 [cited by applicant]
US 20200105373A1 · Zheng · 2020 [cited by applicant]
US 20200263232A1 · Bell et al. · 2020 [cited by applicant]
US 20210190770A1 · Delaney et al. · 2021 [cited by applicant]
US 20210270703A1 · Abousoud · 2021 [cited by applicant]
US 20220403375A1 · Alvarado Martinez · 2022 [cited by applicant]
US 20230167496A1 · Bava · 2023 [cited by applicant]
US 20240002914A1 · Pfeiffer et al. · 2024 [cited by applicant]
EP 1019496B1 · 2004 [cited by applicant]
EP 1841879A2 · 2007 [cited by applicant]
EP 1967592B1 · 2010 [cited by applicant]
EP 2540389A1 · 2013 [cited by applicant]
EP 2635679B1 · 2017 [cited by applicant]
GB 2097692A · 1982 [cited by applicant]
GB 2097692B · 1985 [cited by applicant]
WO WO8402000 · 1984 [cited by applicant]
WO WO9530782 · 1995 [cited by applicant]
WO WO9952708 · 1999 [cited by applicant]
WO WO2000008212A1 · 2000 [cited by applicant]
WO WO2001002850A1 · 2001 [cited by applicant]
WO WO0114589A2 · 2001 [cited by applicant]
WO WO0189787A2 · 2001 [cited by applicant]
WO WO0190418A1 · 2001 [cited by applicant]
WO WO2004002627A2 · 2004 [cited by applicant]
WO WO2004065617A2 · 2004 [cited by applicant]
WO WO2004069849A2 · 2004 [cited by applicant]
WO WO2004091763A2 · 2004 [cited by applicant]
WO WO2005021151A1 · 2005 [cited by applicant]
WO WO2005040406A1 · 2005 [cited by applicant]
WO WO2005049787A9 · 2005 [cited by applicant]
WO WO2005082098A2 · 2005 [cited by applicant]
WO WO2006040551A2 · 2006 [cited by applicant]
WO WO2006078841A1 · 2006 [cited by applicant]
WO WO2006096571A2 · 2006 [cited by applicant]
WO WO2007081385A2 · 2007 [cited by applicant]
WO WO2007081387A1 · 2007 [cited by applicant]
WO WO2007089541A2 · 2007 [cited by applicant]
WO WO2007133710A2 · 2007 [cited by applicant]
WO WO2007140015A2 · 2007 [cited by applicant]
WO WO2007147079A2 · 2007 [cited by applicant]
WO WO2008021123A1 · 2008 [cited by applicant]
WO WO2008109176A2 · 2008 [cited by applicant]
WO WO2008121342A2 · 2008 [cited by applicant]
WO WO2008134153A1 · 2008 [cited by applicant]
WO WO2008150432A1 · 2008 [cited by applicant]
WO WO2009011808A1 · 2009 [cited by applicant]
WO WO2009015296A1 · 2009 [cited by applicant]
WO WO2009085215A1 · 2009 [cited by applicant]
WO WO2009152928A2 · 2009 [cited by applicant]
WO WO2010033200A2 · 2010 [cited by applicant]
WO WO2010104604A1 · 2010 [cited by applicant]
WO WO2010117620A2 · 2010 [cited by applicant]
WO WO2010148039A2 · 2010 [cited by applicant]
WO WO2011028539A1 · 2011 [cited by applicant]
WO WO2011047870A1 · 2011 [cited by applicant]
WO WO2011056546A1 · 2011 [cited by applicant]
WO WO2011066476A1 · 2011 [cited by applicant]
WO WO2012048341A1 · 2012 [cited by applicant]
WO WO2012061832A1 · 2012 [cited by applicant]
WO WO2012083225A2 · 2012 [cited by applicant]
WO WO2012106546A2 · 2012 [cited by applicant]
WO WO2012112804A1 · 2012 [cited by applicant]
WO WO2012112970A2 · 2012 [cited by applicant]
WO WO2012116331A2 · 2012 [cited by applicant]
WO WO2012142531A2 · 2012 [cited by applicant]
WO WO2012142611A2 · 2012 [cited by applicant]
WO WO2012149042A2 · 2012 [cited by applicant]
WO WO2012166425A2 · 2012 [cited by applicant]
WO WO2012167142A2 · 2012 [cited by applicant]
WO WO2013019751A1 · 2013 [cited by applicant]
WO WO2013036929A1 · 2013 [cited by applicant]
WO WO2013055955A1 · 2013 [cited by applicant]
WO WO2013096643A1 · 2013 [cited by applicant]
WO WO2013126741A1 · 2013 [cited by applicant]
WO WO2013134261A1 · 2013 [cited by applicant]
WO WO2014028378A2 · 2014 [cited by applicant]
WO WO2014108810A2 · 2014 [cited by applicant]
WO WO2014165559A2 · 2014 [cited by applicant]
WO WO2014182835A1 · 2014 [cited by applicant]
WO WO2014200767A1 · 2014 [cited by applicant]
WO WO2015015199A2 · 2015 [cited by applicant]
WO WO2015044428A1 · 2015 [cited by applicant]
WO WO2015164212A1 · 2015 [cited by applicant]
WO WO2016040476A1 · 2016 [cited by applicant]
WO WO2016061517A2 · 2016 [cited by applicant]
WO WO2016126871A2 · 2016 [cited by applicant]
WO WO2016168584A1 · 2016 [cited by applicant]
WO WO2016174229A1 · 2016 [cited by applicant]
WO WO2017015075A1 · 2017 [cited by applicant]
WO WO2017066231A1 · 2017 [cited by applicant]
WO WO2017075265A1 · 2017 [cited by applicant]
WO WO2017075294A1 · 2017 [cited by applicant]
WO WO2017117358A1 · 2017 [cited by applicant]
WO WO2017180949A1 · 2017 [cited by applicant]
WO WO2017184707A1 · 2017 [cited by applicant]
WO WO2017197343A2 · 2017 [cited by applicant]
WO WO2018039338A1 · 2018 [cited by applicant]
WO WO2018058073A2 · 2018 [cited by applicant]
WO WO2018091676A1 · 2018 [cited by applicant]
WO WO2018119301A1 · 2018 [cited by applicant]
WO WO2018119447A2 · 2018 [cited by applicant]
WO WO2018125982A1 · 2018 [cited by applicant]
WO WO2018172726A1 · 2018 [cited by applicant]
WO WO2018174827A1 · 2018 [cited by applicant]
WO WO2018191701A1 · 2018 [cited by applicant]
WO WO2018213643A1 · 2018 [cited by applicant]
WO WO2018226546A1 · 2018 [cited by applicant]
WO WO2018236615A1 · 2018 [cited by applicant]
WO WO2019028166A1 · 2019 [cited by applicant]
WO WO2019040637A1 · 2019 [cited by applicant]
WO WO2019083852A1 · 2019 [cited by applicant]
WO WO2019084043A1 · 2019 [cited by applicant]
WO WO2019084165A1 · 2019 [cited by applicant]
WO WO2019108851A1 · 2019 [cited by applicant]
WO WO2019113235A1 · 2019 [cited by applicant]
WO WO2019118355A1 · 2019 [cited by applicant]
Cited By (16)
US 12,312,640 US 12,365,893 US 12,391,976 US 12,398,262 US 12,416,102 US 12,467,088 US 12,534,760 US 12,553,074 US 12,600,961 US 12,606,860 US 12,612,714 US 12,655,450 US 12,686,949 US 12,692,536 US 12,729,402 US 12,735,810