Granted Patent
B2
US 12,234,505 · App. 18/793,359 · Granted Feb 25, 2025
Spatially encoded biological assays
Assignee:
Prognosys Biosciences, Inc.
C12Q1/6837B01L3/502715C12Q1/68C12Q1/6804C12Q1/6809C12Q1/6834C12Q1/6841C12Q1/6869C12Q1/6874C12Q1/6876C40B30/04C40B60/04G01N33/5308G01N33/543G01N33/54366G01N33/6845G01N33/6848C12Q1/6858C12Q2600/156C12Q2600/158G01N2458/10G01N2458/40
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Abstract
The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.
Claims (32)
1. A method of determining spatial distribution of target biological molecules in a tissue sample, comprising:
(a) providing the tissue sample comprising the target biological molecules;
(b) allowing the target biological molecules to interact with nucleic acid probes;
(c) coupling encoded oligonucleotides to the nucleic acid probes, wherein the encoded oligonucleotides are arranged according to a known spatial pattern;
(d) determining sequences of the encoded oligonucleotides coupled to the nucleic acid probes; and
(e) mapping the target biological molecules to locations in the tissue sample using the sequences of the encoded oligonucleotides.
2. The method of claim 1 , wherein the coupling comprises ligation.
3. The method of claim 2 , wherein the ligation is enzymatic or chemical ligation.
4. The method of claim 1 , wherein the coupling is performed by extension followed by ligation.
5. The method of claim 1 , wherein the tissue sample is a fresh frozen or FFPE tissue sample.
6. The method of claim 5 , wherein the tissue sample is a tissue section.
7. The method of claim 1 , wherein the target biological molecules comprise nucleic acids.
8. The method of claim 7 , wherein the nucleic acids are RNA molecules.
9. The method of claim 8 , wherein the RNA molecules are mRNA molecules.
10. The method of claim 7 , wherein the nucleic acids are DNA molecules.
11. The method of claim 1 , wherein (b) comprises hybridizing the target biological molecules to the nucleic acid probes.
12. The method of claim 11 , wherein the method further comprises extending the nucleic acid probes using the hybridized target biological molecules as a template.
13. The method of claim 12 , wherein the extending is performed by a polymerase.
14. The method of claim 1 , wherein the determining in step (d) comprises next-generation sequencing.
15. The method of claim 1 , wherein the encoded oligonucleotides are immobilized directly or indirectly on a substrate.
16. The method of claim 15 , wherein the substrate is a flow-cell or a slide.
17. The method of claim 1 , wherein the encoded oligonucleotides are immobilized in wells or channels.
18. The method of claim 1 , wherein the nucleic acid probes further comprise a universal priming site.
19. The method of claim 1 , wherein the encoded oligonucleotides further comprise a universal priming site.
20. The method of claim 1 , further comprising staining the tissue sample.
21. The method of claim 20 , wherein the staining is selected from immunohistochemistry, hematoxylin, or eosin staining.
22. The method of claim 1 , further comprising separating the nucleic acid probes that do not interact with the target biological molecules from the tissue sample.
23. The method of claim 22 , wherein the separating comprises washing the tissue sample.
24. The method of claim 23 , wherein an amplification step occurs between washing the tissue sample and the determining of step (d).
25. The method of claim 1 , wherein the determining comprises sequencing at least 50,000 encoded oligonucleotides.
26. The method of claim 1 , further comprising determining abundance of the target biological molecules in the tissue sample.
27. The method of claim 26 , wherein the abundance of the target biological molecules is a measure of gene expression in the tissue sample.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 14, 2024
From: CHEE, MARK S.
To: PROGNOSYS BIOSCIENCES, INC.
Reel/Frame 068883/0755 →
Continuity (13)
Provisional Application
61321124
· Apr 5, 2010
References Cited (400)
US 4514388A
· Psaledakis
· 1985
[cited by applicant]
US 4557903A
· McCormick
· 1985
[cited by applicant]
US 4574729A
· Wells
· 1986
[cited by applicant]
US 4683195A
· Mullis
· 1987
[cited by applicant]
US 4683202A
· Mullis
· 1987
[cited by applicant]
US 4731335A
· Brigati
· 1988
[cited by applicant]
US 4800159A
· Mullis
· 1989
[cited by applicant]
US 4883867A
· Lee
· 1989
[cited by applicant]
US 4965188A
· Mullis
· 1990
[cited by applicant]
US 4968601A
· Jacobson et al.
· 1990
[cited by applicant]
US 4988617A
· Landegren et al.
· 1991
[cited by applicant]
US 5002882A
· Lunnen
· 1991
[cited by applicant]
US 5061049A
· Hornbeck
· 1991
[cited by applicant]
US 5130238A
· Malek
· 1992
[cited by applicant]
US 5183053A
· Yeh et al.
· 1993
[cited by applicant]
US 5308751A
· Ohkawa
· 1994
[cited by applicant]
US 5321130A
· Yue
· 1994
[cited by applicant]
US 5410030A
· Yue
· 1995
[cited by applicant]
US 5436129A
· Stapleton
· 1995
[cited by applicant]
US 5436134A
· Haugland
· 1995
[cited by applicant]
US 5455166A
· Walker
· 1995
[cited by applicant]
US 5472881A
· Beebe et al.
· 1995
[cited by applicant]
US 5487972A
· Gelfand et al.
· 1996
[cited by applicant]
US 5494810A
· Barany et al.
· 1996
[cited by applicant]
US 5496518A
· Arai et al.
· 1996
[cited by applicant]
US 5503980A
· Cantor
· 1996
[cited by applicant]
US 5512439A
· Hornes
· 1996
[cited by applicant]
US 5512462A
· Cheng
· 1996
[cited by applicant]
US 5559032A
· Porneroy
· 1996
[cited by applicant]
US 5582977A
· Yue
· 1996
[cited by applicant]
US 5589173A
· O'Brien
· 1996
[cited by applicant]
US 5599675A
· Brenner
· 1997
[cited by applicant]
US 5610287A
· Nikiforov et al.
· 1997
[cited by applicant]
US 5641658A
· Adams
· 1997
[cited by applicant]
US 5648245A
· Fire et al.
· 1997
[cited by applicant]
US 5658751A
· Yue
· 1997
[cited by applicant]
US 5672344A
· Kelley et al.
· 1997
[cited by applicant]
US 5695940A
· Drmanac et al.
· 1997
[cited by applicant]
US 5716825A
· Hancock et al.
· 1998
[cited by applicant]
US 5750341A
· Macevicz
· 1998
[cited by applicant]
US 5752982A
· Lang et al.
· 1998
[cited by applicant]
US 5763175A
· Brenner
· 1998
[cited by applicant]
US 5807522A
· Brown et al.
· 1998
[cited by applicant]
US 5817783A
· Calabretta et al.
· 1998
[cited by applicant]
US 5830711A
· Barany et al.
· 1998
[cited by applicant]
US 5837832A
· Chee et al.
· 1998
[cited by applicant]
US 5837860A
· Anderson et al.
· 1998
[cited by applicant]
US 5854033A
· Lizardi
· 1998
[cited by applicant]
US 5863753A
· Haugland
· 1999
[cited by applicant]
US 5866377A
· Kim et al.
· 1999
[cited by applicant]
US 5871921A
· Landegren et al.
· 1999
[cited by applicant]
US 5875258A
· Ortyn et al.
· 1999
[cited by applicant]
US 5912148A
· Eggerding
· 1999
[cited by applicant]
US 5919626A
· Shi et al.
· 1999
[cited by applicant]
US 5925545A
· Reznikoff et al.
· 1999
[cited by applicant]
US 5928906A
· Koester et al.
· 1999
[cited by applicant]
US 5958775A
· Wickstrom et al.
· 1999
[cited by applicant]
US 5962271A
· Chenchik et al.
· 1999
[cited by applicant]
US 5962272A
· Chenchik et al.
· 1999
[cited by applicant]
US 5965443A
· Reznikoff et al.
· 1999
[cited by applicant]
US 5994136A
· Naldini et al.
· 1999
[cited by applicant]
US 6013440A
· Lipshutz
· 2000
[cited by applicant]
US 6013516A
· Verma et al.
· 2000
[cited by applicant]
US 6027889A
· Barany et al.
· 2000
[cited by applicant]
US 6054274A
· Sampson et al.
· 2000
[cited by applicant]
US 6060240A
· Kamb et al.
· 2000
[cited by applicant]
US 6083761A
· Kedar et al.
· 2000
[cited by applicant]
US 6130073A
· Eggerding
· 2000
[cited by applicant]
US 6133436A
· Koester et al.
· 2000
[cited by applicant]
US 6136592A
· Leighton
· 2000
[cited by applicant]
US 6143496A
· Brown
· 2000
[cited by applicant]
US 6153389A
· Haarer
· 2000
[cited by applicant]
US 6153408A
· Abastado et al.
· 2000
[cited by applicant]
US 6157432A
· Helbing
· 2000
[cited by applicant]
US 6159736A
· Reznikoff et al.
· 2000
[cited by applicant]
US 6165714A
· Lane et al.
· 2000
[cited by applicant]
US 6172218B1
· Brenner
· 2001
[cited by applicant]
US 6210891B1
· Nyren
· 2001
[cited by applicant]
US 6210894B1
· Brennan
· 2001
[cited by applicant]
US 6214587B1
· Dattagupta
· 2001
[cited by applicant]
US 6221591B1
· Aerts
· 2001
[cited by applicant]
US 6221654B1
· Quake
· 2001
[cited by applicant]
US 6251639B1
· Kurn
· 2001
[cited by applicant]
US 6258558B1
· Szostak
· 2001
[cited by applicant]
US 6258568B1
· Nyren
· 2001
[cited by applicant]
US 6261804B1
· Szostak
· 2001
[cited by applicant]
US 6265552B1
· Schatz
· 2001
[cited by applicant]
US 6266459B1
· Walt
· 2001
[cited by applicant]
US 6268148B1
· Barany et al.
· 2001
[cited by applicant]
US 6274320B1
· Rothberg
· 2001
[cited by applicant]
US 6281804B1
· Haller
· 2001
[cited by applicant]
US 6291180B1
· Chu
· 2001
[cited by applicant]
US 6291187B1
· Kingsmore et al.
· 2001
[cited by applicant]
US 6300063B1
· Lipshutz et al.
· 2001
[cited by applicant]
US 6300093B1
· Kindsvogel et al.
· 2001
[cited by applicant]
US 6306597B1
· Macevicz
· 2001
[cited by applicant]
US 6309824B1
· Drmanac
· 2001
[cited by applicant]
US 6323009B1
· Lasken et al.
· 2001
[cited by applicant]
US 6337472B1
· Garner et al.
· 2002
[cited by applicant]
US 6344316B1
· Lockhart
· 2002
[cited by applicant]
US 6344329B1
· Lizardi et al.
· 2002
[cited by applicant]
US 6348990B1
· Igasaki et al.
· 2002
[cited by applicant]
US 6355431B1
· Chee
· 2002
[cited by applicant]
US 6368801B1
· Faruqi
· 2002
[cited by applicant]
US 6391937B1
· Beuhler et al.
· 2002
[cited by applicant]
US 6401267B1
· Drmanac
· 2002
[cited by applicant]
US 6404907B1
· Gilchrist
· 2002
[cited by applicant]
US 6416950B1
· Lohse
· 2002
[cited by applicant]
US 6426215B1
· Sandell
· 2002
[cited by applicant]
US 6432360B1
· Church et al.
· 2002
[cited by applicant]
US 6444661B1
· Barton et al.
· 2002
[cited by applicant]
US 6485982B1
· Charlton
· 2002
[cited by applicant]
US 6503713B1
· Rana
· 2003
[cited by applicant]
US 6506561B1
· Cheval et al.
· 2003
[cited by applicant]
US 6518018B1
· Szostak
· 2003
[cited by applicant]
US 6534266B1
· Singer
· 2003
[cited by applicant]
US 6544732B1
· Chee
· 2003
[cited by applicant]
US 6544790B1
· Sabatini
· 2003
[cited by applicant]
US 6565727B1
· Shenderov
· 2003
[cited by applicant]
US 6573043B1
· Cohen et al.
· 2003
[cited by applicant]
US 6579695B1
· Lambalot
· 2003
[cited by applicant]
US 6620584B1
· Chee
· 2003
[cited by applicant]
US 6632641B1
· Brennan
· 2003
[cited by applicant]
US 6673620B1
· Loeffler
· 2004
[cited by applicant]
US 6677160B1
· Stockman et al.
· 2004
[cited by applicant]
US 6699710B1
· Kononen
· 2004
[cited by applicant]
US 6737236B1
· Pieken et al.
· 2004
[cited by applicant]
US 6770441B2
· Dickinson
· 2004
[cited by applicant]
US 6773566B2
· Shenderov
· 2004
[cited by applicant]
US 6773886B2
· Kaufman
· 2004
[cited by applicant]
US 6787308B2
· Balasubramanian
· 2004
[cited by applicant]
US 6797470B2
· Barany et al.
· 2004
[cited by applicant]
US 6800453B2
· Labaer
· 2004
[cited by applicant]
US 6812005B2
· Fan et al.
· 2004
[cited by applicant]
US 6828100B1
· Ronaghi
· 2004
[cited by applicant]
US 6833246B2
· Balasubramanian
· 2004
[cited by applicant]
US 6852487B1
· Barany et al.
· 2005
[cited by applicant]
US 6859570B2
· Walt
· 2005
[cited by applicant]
US 6864052B1
· Drmanac
· 2005
[cited by applicant]
US 6867028B2
· Janulaitis
· 2005
[cited by applicant]
US 6872816B1
· Hall et al.
· 2005
[cited by applicant]
US 6875572B2
· Prudent et al.
· 2005
[cited by applicant]
US 6878515B1
· Landegren
· 2005
[cited by applicant]
US 6890741B2
· Fan et al.
· 2005
[cited by applicant]
US 6897023B2
· Fu
· 2005
[cited by applicant]
US 6911132B2
· Pamula
· 2005
[cited by applicant]
US 6911345B2
· Quake
· 2005
[cited by applicant]
US 6913881B1
· Aizenstein et al.
· 2005
[cited by applicant]
US 6913921B2
· Fischer
· 2005
[cited by applicant]
US 6942968B1
· Dickinson et al.
· 2005
[cited by applicant]
US 6969488B2
· Bridgham
· 2005
[cited by applicant]
US 6969589B2
· Patil
· 2005
[cited by applicant]
US 6977033B2
· Becker
· 2005
[cited by applicant]
US 7001792B2
· Sauer et al.
· 2006
[cited by applicant]
US 7011944B2
· Prudent et al.
· 2006
[cited by applicant]
US 7052244B2
· Fouillet
· 2006
[cited by applicant]
US 7057026B2
· Barnes
· 2006
[cited by applicant]
US 7060431B2
· Chee et al.
· 2006
[cited by applicant]
US 7083980B2
· Reznikoff et al.
· 2006
[cited by applicant]
US 7098041B2
· Kaylor et al.
· 2006
[cited by applicant]
US 7115400B1
· Adessi
· 2006
[cited by applicant]
US 7118883B2
· Inoue
· 2006
[cited by applicant]
US 7128893B2
· Leamon et al.
· 2006
[cited by applicant]
US 7163612B2
· Sterling
· 2007
[cited by applicant]
US 7166431B2
· Chee et al.
· 2007
[cited by applicant]
US 7192735B2
· Lambalot
· 2007
[cited by applicant]
US 7211414B2
· Hardin
· 2007
[cited by applicant]
US 7223371B2
· Hayenga et al.
· 2007
[cited by applicant]
US 7229769B2
· Kozlov
· 2007
[cited by applicant]
US 7244559B2
· Rothberg
· 2007
[cited by applicant]
US 7255994B2
· Lao
· 2007
[cited by applicant]
US 7258976B2
· Mitsuhashi
· 2007
[cited by applicant]
US 7259258B2
· Kozlov et al.
· 2007
[cited by applicant]
US 7264929B2
· Rothberg
· 2007
[cited by applicant]
US 7270950B2
· Szostak
· 2007
[cited by applicant]
US 7282328B2
· Kong et al.
· 2007
[cited by applicant]
US 7297518B2
· Quake
· 2007
[cited by applicant]
US 7315019B2
· Turner
· 2008
[cited by applicant]
US 7328979B2
· Decre
· 2008
[cited by applicant]
US 7329492B2
· Hardin
· 2008
[cited by applicant]
US 7358047B2
· Hafner et al.
· 2008
[cited by applicant]
US 7361488B2
· Fan et al.
· 2008
[cited by applicant]
US 7375234B2
· Sharpless et al.
· 2008
[cited by applicant]
US 7378242B2
· Hurt
· 2008
[cited by applicant]
US 7393665B2
· Brenner
· 2008
[cited by applicant]
US 7405281B2
· Xu
· 2008
[cited by applicant]
US 7407757B2
· Brenner
· 2008
[cited by applicant]
US 7427678B2
· Pieken et al.
· 2008
[cited by applicant]
US 7456012B2
· Ryttsen et al.
· 2008
[cited by applicant]
US 7462449B2
· Quake
· 2008
[cited by applicant]
US 7473767B2
· Dimitrov
· 2009
[cited by applicant]
US 7499806B2
· Kermani et al.
· 2009
[cited by applicant]
US 7501245B2
· Quake
· 2009
[cited by applicant]
US 7534991B2
· Miller et al.
· 2009
[cited by applicant]
US 7537897B2
· Brenner
· 2009
[cited by applicant]
US 7544473B2
· Brennan
· 2009
[cited by applicant]
US 7547380B2
· Velev
· 2009
[cited by applicant]
US 7555155B2
· Levenson et al.
· 2009
[cited by applicant]
US 7561336B2
· Osaka et al.
· 2009
[cited by applicant]
US 7563576B2
· Chee
· 2009
[cited by applicant]
US 7579153B2
· Brenner
· 2009
[cited by applicant]
US 7582420B2
· Oliphant et al.
· 2009
[cited by applicant]
US 7595883B1
· El Gamal
· 2009
[cited by applicant]
US 7601492B2
· Fu et al.
· 2009
[cited by applicant]
US 7601498B2
· Mao
· 2009
[cited by applicant]
US 7608434B2
· Reznikoff et al.
· 2009
[cited by applicant]
US 7611869B2
· Fan
· 2009
[cited by applicant]
US 7635566B2
· Brenner
· 2009
[cited by applicant]
US 7641779B2
· Becker
· 2010
[cited by applicant]
US 7655898B2
· Miller
· 2010
[cited by applicant]
US 7666612B2
· Johnsson
· 2010
[cited by applicant]
US 7674589B2
· Cohen et al.
· 2010
[cited by applicant]
US 7674752B2
· He
· 2010
[cited by applicant]
US 7700286B2
· Stroun et al.
· 2010
[cited by applicant]
US 7709198B2
· Luo et al.
· 2010
[cited by applicant]
US 7754429B2
· Rigatti
· 2010
[cited by applicant]
US 7776547B2
· Roth
· 2010
[cited by applicant]
US 7776567B2
· Mao
· 2010
[cited by applicant]
US 7785869B2
· Belgrader et al.
· 2010
[cited by applicant]
US 7803943B2
· Mao
· 2010
[cited by applicant]
US 7844940B2
· Shin et al.
· 2010
[cited by applicant]
US 7848553B2
· Hertel et al.
· 2010
[cited by applicant]
US 7858321B2
· Glezer
· 2010
[cited by applicant]
US 7888009B2
· Barany et al.
· 2011
[cited by applicant]
US 7892747B2
· Barany et al.
· 2011
[cited by applicant]
US 7910304B2
· Drmanac
· 2011
[cited by applicant]
US 7914981B2
· Barany et al.
· 2011
[cited by applicant]
US 7941279B2
· Hwang et al.
· 2011
[cited by applicant]
US 7955794B2
· Shen et al.
· 2011
[cited by applicant]
US 7960119B2
· Chee
· 2011
[cited by applicant]
US 7960120B2
· Rigatti
· 2011
[cited by applicant]
US 7985565B2
· Mayer et al.
· 2011
[cited by applicant]
US 8003354B2
· Shen et al.
· 2011
[cited by applicant]
US 8030477B2
· Cerrina et al.
· 2011
[cited by applicant]
US 8046043B2
· Asano et al.
· 2011
[cited by applicant]
US 8076063B2
· Fan
· 2011
[cited by applicant]
US 8092784B2
· Mao
· 2012
[cited by applicant]
US 8124751B2
· Pierce et al.
· 2012
[cited by applicant]
US 8131476B2
· Cline et al.
· 2012
[cited by applicant]
US 8148068B2
· Brenner
· 2012
[cited by applicant]
US 8148518B2
· Buchanan
· 2012
[cited by applicant]
US 8198028B2
· Rigatti et al.
· 2012
[cited by applicant]
US 8199999B2
· Hoyt et al.
· 2012
[cited by applicant]
US 8206917B2
· Chee
· 2012
[cited by applicant]
US 8207093B2
· Szostak
· 2012
[cited by applicant]
US 8268554B2
· Schallmeiner
· 2012
[cited by applicant]
US 8278034B2
· Muraca
· 2012
[cited by applicant]
US 8288103B2
· Oliphant
· 2012
[cited by applicant]
US 8288122B2
· O'Leary et al.
· 2012
[cited by applicant]
US 8330087B2
· Domenicali
· 2012
[cited by applicant]
US 8337851B2
· Aukerman
· 2012
[cited by applicant]
US 8343500B2
· Wraith
· 2013
[cited by applicant]
US 8383338B2
· Kitzman
· 2013
[cited by applicant]
US 8415102B2
· Geiss et al.
· 2013
[cited by applicant]
US 8431691B2
· McKernan et al.
· 2013
[cited by applicant]
US 8460865B2
· Chee
· 2013
[cited by applicant]
US 8462981B2
· Determan et al.
· 2013
[cited by applicant]
US 8481257B2
· Van Eijk
· 2013
[cited by applicant]
US 8481258B2
· Church et al.
· 2013
[cited by applicant]
US 8481292B2
· Casbon
· 2013
[cited by applicant]
US 8481698B2
· Lieberman et al.
· 2013
[cited by applicant]
US 8486625B2
· Gunderson
· 2013
[cited by applicant]
US 8507204B2
· Pierce et al.
· 2013
[cited by applicant]
US 8519115B2
· Webster et al.
· 2013
[cited by applicant]
US 8551710B2
· Bernitz et al.
· 2013
[cited by applicant]
US 8568979B2
· Stuelpnagel et al.
· 2013
[cited by applicant]
US RE44596E
· Stroun et al.
· 2013
[cited by applicant]
US 8586310B2
· Mitra
· 2013
[cited by applicant]
US 8597891B2
· Barany et al.
· 2013
[cited by applicant]
US 8603743B2
· Liu et al.
· 2013
[cited by applicant]
US 8604182B2
· Luo et al.
· 2013
[cited by applicant]
US 8614073B2
· Van Eijk
· 2013
[cited by applicant]
US 8624016B2
· Barany et al.
· 2014
[cited by applicant]
US 8637242B2
· Shen
· 2014
[cited by applicant]
US 8658361B2
· Wu et al.
· 2014
[cited by applicant]
US 8685889B2
· Van Eijk
· 2014
[cited by applicant]
US 8741564B2
· Seligmann
· 2014
[cited by applicant]
US 8741606B2
· Casbon
· 2014
[cited by applicant]
US 8748103B2
· Faham et al.
· 2014
[cited by applicant]
US 8771950B2
· Church et al.
· 2014
[cited by applicant]
US 8778849B2
· Bowen
· 2014
[cited by applicant]
US 8785353B2
· Van Eijk
· 2014
[cited by applicant]
US 8790873B2
· Namsaraev et al.
· 2014
[cited by applicant]
US 8809238B2
· Livak et al.
· 2014
[cited by applicant]
US 8815512B2
· Van Eijk
· 2014
[cited by applicant]
US 8835358B2
· Fodor
· 2014
[cited by applicant]
US 8865410B2
· Shendure
· 2014
[cited by applicant]
US 8906626B2
· Oliphant et al.
· 2014
[cited by applicant]
US 8911945B2
· Van Eijk
· 2014
[cited by applicant]
US 8936912B2
· Mitra
· 2015
[cited by applicant]
US 8951726B2
· Luo et al.
· 2015
[cited by applicant]
US 8951728B2
· Rasmussen
· 2015
[cited by applicant]
US 8951781B2
· Reed
· 2015
[cited by applicant]
US 8986926B2
· Ferree et al.
· 2015
[cited by applicant]
US 9005891B2
· Sinicropi et al.
· 2015
[cited by applicant]
US 9005935B2
· Belyaev
· 2015
[cited by applicant]
US 9023768B2
· Van Eijk
· 2015
[cited by applicant]
US 9062348B1
· Van Eijk
· 2015
[cited by applicant]
US 9080210B2
· Van Eijk
· 2015
[cited by applicant]
US 9085798B2
· Chee
· 2015
[cited by applicant]
US 9121069B2
· Lo
· 2015
[cited by applicant]
US 9163283B2
· Chee et al.
· 2015
[cited by applicant]
US 9194001B2
· Brenner
· 2015
[cited by applicant]
US 9201063B2
· Sood et al.
· 2015
[cited by applicant]
US 9217176B2
· Faham et al.
· 2015
[cited by applicant]
US 9290808B2
· Fodor
· 2016
[cited by applicant]
US 9290809B2
· Fodor
· 2016
[cited by applicant]
US 9309556B2
· Myllykangas et al.
· 2016
[cited by applicant]
US 9328383B2
· Van Eijk
· 2016
[cited by applicant]
US 9334536B2
· Van Eijk
· 2016
[cited by applicant]
US 9340830B2
· Lipson
· 2016
[cited by applicant]
US 9371563B2
· Geiss et al.
· 2016
[cited by applicant]
US 9371598B2
· Chee
· 2016
[cited by applicant]
US 9376716B2
· Van Eijk
· 2016
[cited by applicant]
US 9376717B2
· Gao et al.
· 2016
[cited by applicant]
US 9376719B2
· Van Eijk
· 2016
[cited by applicant]
US 9404156B2
· Hicks
· 2016
[cited by applicant]
US 9416409B2
· Hayden
· 2016
[cited by applicant]
US 9447459B2
· Van Eijk
· 2016
[cited by applicant]
US 9453256B2
· Van Eijk
· 2016
[cited by applicant]
US 9493820B2
· Van Eijk
· 2016
[cited by applicant]
US 9494588B2
· Springer
· 2016
[cited by applicant]
US 9506061B2
· Brown
· 2016
[cited by applicant]
US 9512487B2
· Faham et al.
· 2016
[cited by applicant]
US 9541504B2
· Hoyt
· 2017
[cited by applicant]
US 9557330B2
· Siciliano et al.
· 2017
[cited by applicant]
US 9574230B2
· Van Eijk
· 2017
[cited by applicant]
US 9593365B2
· Frisen et al.
· 2017
[cited by applicant]
US 9598728B2
· Barany et al.
· 2017
[cited by applicant]
US 9624538B2
· Church et al.
· 2017
[cited by applicant]
US 9657335B2
· Van Eijk
· 2017
[cited by applicant]
US 9670542B2
· Van Eijk
· 2017
[cited by applicant]
US 9671344B2
· Staker
· 2017
[cited by applicant]
US 9694361B2
· Bharadwaj
· 2017
[cited by applicant]
US 9702004B2
· Van Eijk
· 2017
[cited by applicant]
US 9714446B2
· Webster et al.
· 2017
[cited by applicant]
US 9714937B2
· Dunaway
· 2017
[cited by applicant]
US 9745627B2
· Van Eijk
· 2017
[cited by applicant]
US 9777324B2
· Van Eijk
· 2017
[cited by applicant]
US 9816134B2
· Namsaraev
· 2017
[cited by applicant]
US 9850536B2
· Oliphant et al.
· 2017
[cited by applicant]
US 9868979B2
· Chee et al.
· 2018
[cited by applicant]
US 9879313B2
· Chee et al.
· 2018
[cited by applicant]
US 9889422B2
· Smith et al.
· 2018
[cited by applicant]
US 9896721B2
· Van Eijk
· 2018
[cited by applicant]
US 9898576B2
· Van Eijk
· 2018
[cited by applicant]
US 9898577B2
· Van Eijk
· 2018
[cited by applicant]
US 9902950B2
· Church et al.
· 2018
[cited by applicant]
US 9902991B2
· Sinicropi et al.
· 2018
[cited by applicant]
US 9958454B2
· Kozlov et al.
· 2018
[cited by applicant]
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