Granted Patent B2

US 12,419,932 · App. 18/821,027 · Granted Sep 23, 2025

Inventors: Edward J. Delaney (Princeton, NJ); Carolyn Durham (Chapel Hill, NC); Daniel W. Copeland (Chapel Hill, NC)

Assignee: Renovion, Inc.

A61K38/063A61K9/08A61K31/375

Abstract

Claims (12)

1. A method of making a preparation comprising an aqueous solution in a closed container with a headspace, wherein:

(i) the aqueous solution comprises a salt having Formula I:

(ii) the atmosphere of the headspace comprises 90% or more carbon dioxide by volume; and

(iii) M + is Na + ,

the method comprising:

(i) dissolving L-glutathione, ascorbic acid, and sodium bicarbonate in water for injection under carbon dioxide to give an aqueous solution;

(ii) transferring a portion of the aqueous solution to a container;

(iii) overlaying the aqueous solution with carbon dioxide; and

(iv) sealing the container with a stopper,

wherein about 8 wt % to about 18 wt % of L-glutathione, about 3 wt % to about 13 wt % of ascorbic acid, and about 3 wt % to about 13 wt % of sodium bicarbonate is dissolved in about 62 wt % to about 82 wt % water for injection to give the aqueous solution.

2. The method of making the preparation of claim 1 , wherein about 11 wt % to about 15 wt % of L-glutathione, about 5 wt % to about 9 wt % of ascorbic acid, and about 5 wt % to about 9 wt % of sodium bicarbonate is dissolved in about 68 wt % to about 76 wt % water to give the aqueous solution.

3. The method of making the preparation of claim 2 , wherein about 13.0 wt % of L-glutathione, about 7.6 wt % of ascorbic acid, and about 7.3 wt % of sodium bicarbonate is dissolved in about 72.0 wt % water to give the aqueous solution.

Assignments (1)

Continuity (4)

References Cited (296)