Systems, devices, and methods for electrophysiological recording from the eye
Systems, devices, and methods for electrophysiological recording from the eye are disclosed herein. An electroretinography device can detect a biopotential signal from an eye of a subject and transmit the same to a processor. Embodiments of the present technology include one or more features directed to improving the use and operability of an electroretinography device. For example, the device can include features for (i) improving the quality of light stimulus delivered to the eye or (ii) providing a better fit around the eye or a contact lens worn on the eye. These features can account for anatomical differences between different subjects by either masking or accommodating such differences.
1 . An electroretinography device configured to detect a biopotential signal from an eye of a subject, comprising:
an ocular member including:
a proximal portion comprising a proximal outer surface extending radially inward along a distal direction and a proximal inner surface opposite the outer surface, wherein, when the ocular member is disposed over the eye, the proximal inner surface is disposed over an anterior surface of the eye and the proximal outer surface is positioned adjacent an eyelid of the subject; and
a distal portion coupled to the proximal portion, wherein the distal portion comprises a distal outer surface extending radially outward in the distal direction, and a distal inner surface opposite the distal outer surface and defining at least in part a distal recess, wherein at least a portion the distal inner surface is roughened or non-smooth, and is configured to provide a light scattering effect upon a light stimulus being delivered to the device;
a conductive element in an annular channel of the proximal portion; and
a signal relay operatively connected to the conductive element and configured to transmit the biopotential signal from the conductive element to a signal processor.
2 . The device of claim 1 , wherein an entirety of the distal inner surface is roughened or non-smooth.
3 . The device of claim 1 , wherein only a portion of the distal inner surface is roughened or non-smooth.
4 . The device of claim 1 , wherein:
the proximal inner surface includes (i) a cornea portion and (ii) a sclera portion extending radially around the cornea portion,
the sclera portion has a first cross-sectional dimension and the cornea portion has a second cross-sectional dimension smaller than the first cross-sectional dimension,
the sclera portion is roughened or non-smooth, and
the cornea portion comprises a smooth texture.
5 . The device of claim 1 , wherein the portion of the distal inner surface that is roughened or non-smooth is (i) an uneven surface and comprises a plurality of protrusions from a base surface.
6 . The device of claim 1 , further comprising a film positioned at the distal recess, wherein the film has a concave shape configured to conform to at least a portion of a cornea of the eye, wherein an intermediate portion of the film has a first transparency, and wherein a peripheral portion of the film has a second transparency less transparent than the first transparency.
7 . An electroretinography device configured to detect a biopotential signal from an eye of a subject, comprising:
an ocular member including:
a proximal portion comprising a proximal outer surface extending radially inward along a distal direction and a proximal inner surface opposite the outer surface, wherein, when the ocular member is disposed over the eye, the proximal inner surface is disposed over an anterior surface of the eye and the proximal outer surface is positioned adjacent an eyelid of the subject; and
a distal portion coupled to the proximal portion, wherein the distal portion comprises a distal outer surface extending radially outward in the distal direction, and a distal inner surface opposite the distal outer surface and defining at least in part a distal recess, wherein at least a portion the distal inner surface is roughened or non-smooth;
a film positioned at the distal recess, wherein the film has a concave shape configured to conform to at least a portion of a cornea of the eye, wherein an intermediate portion of the film has a first transparency, and wherein a peripheral portion of the film has a second transparency less transparent than the first transparency;
a conductive element in an annular channel of the proximal portion; and
a signal relay operatively connected to the conductive element and configured to transmit the biopotential signal from the conductive element to a signal processor.
8 . The device of claim 7 , wherein an entirety of the distal inner surface is roughened or non-smooth.
9 . The device of claim 7 , wherein only a portion of the distal inner surface is roughened or non-smooth.
10 . The device of claim 7 , wherein the portion of the distal inner surface that is roughened or non-smooth is an uneven surface and comprises a plurality of protrusions from a base surface.