Granted Patent
B2
US 12,478,504 · App. 18/980,392 · Granted Nov 25, 2025
Drug eluting ocular implants
Inventors:
David S. Haffner (Mission Viejo, CA); Kenneth M. Curry (Oceanside, CA); Harold A. Heitzmann (Irvine, CA); David Applegate (Laguna Hills, CA)
Assignee:
Glaukos Corporation
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Abstract
Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allows for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
Claims (33)
1 . An ocular implant configured to deliver a drug within an eye of a subject, the ocular implant comprising:
an outer shell shaped to define an interior space, the outer shell comprising an opening;
a cap positioned at a proximal end of the outer shell;
a drug disposed within the interior space of the outer shell;
a permeable or semi-permeable material positioned at or near the opening of the outer shell, the permeable or semi-permeable material being permeable or semi-permeable to the drug so as to facilitate controlled elution of the drug within an anterior chamber of the eye; and
an anchor configured to affix a distal tip of the ocular implant into scleral tissue of the eye, wherein at least a portion of the anchor is configured to extend into the scleral tissue,
wherein the drug is travoprost.
2 . The ocular implant of claim 1 , further comprising a flange extending radially from a sidewall of the outer shell.
3 . The ocular implant of claim 1 , wherein the drug is configured to elute from the interior space for at least 6 months.
4 . The ocular implant of claim 1 , wherein the drug is configured to elute from the interior space for at least 12 months.
5 . The ocular implant of claim 1 , wherein the drug is configured to elute from the interior space for at least 24 months.
6 . The ocular implant of claim 1 , wherein the ocular implant is configured to be preloaded in a delivery instrument with the drug inside the interior space.
7 . The ocular implant of claim 1 , wherein at least a portion of ocular implant comprises titanium.
8 . The ocular implant of claim 1 , wherein the outer shell comprises titanium.
9 . The ocular implant of claim 1 , wherein the ocular implant comprises a diameter of between 100 and 600 microns.
10 . An ocular implant configured to deliver a drug within an eye of a subject, the ocular implant comprising:
an outer shell shaped to define an interior space, the outer shell comprising an opening;
a permeable or semi-permeable membrane positioned at or near the opening of the outer shell, the permeable or semi-permeable membrane configured to facilitate controlled elution of the drug within an anterior chamber of the eye; and
an anchor configured to affix a distal tip of the ocular implant into an ocular tissue, wherein at least a portion of the anchor is configured to extend into the ocular tissue,
wherein at least a portion of the permeable or semi-permeable membrane is positioned within the interior space of the outer shell.
11 . The ocular implant of claim 10 , wherein the ocular tissue is a portion of a sclera.
12 . The ocular implant of claim 10 , further comprising travoprost disposed within the interior space of the outer shell.
13 . The ocular implant of claim 10 , further comprising an anti-glaucoma medication disposed within the interior space of the outer shell.
14 . The ocular implant of claim 10 , further comprising a flange extending radially from a sidewall of the outer shell.
15 . The ocular implant of claim 10 , wherein at least a portion of the permeable or semi-permeable membrane is positioned outside of the interior space of the outer shell.
16 . The ocular implant of claim 10 , wherein the outer shell comprises titanium.
17 . The ocular implant of claim 10 , wherein the ocular implant comprises a diameter of between 100 and 600 microns.
18 . An ocular implant configured to deliver a drug within an eye of a subject, the ocular implant comprising:
an outer shell shaped to define an interior space, the outer shell comprising an opening;
a cap positioned at a proximal end of the outer shell;
a permeable or semi-permeable membrane positioned at or near the opening of the outer shell, the permeable or semi-permeable membrane configured to facilitate controlled elution of the drug within an anterior chamber of the eye; and
an anchor configured to affix a distal tip of the ocular implant into an ocular tissue, wherein at least a portion of the anchor is configured to extend into the ocular tissue.
19 . The ocular implant of claim 18 , wherein the cap is a crimp cap.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 30, 2025
From: DOSE MEDICAL CORPORATION
To: GLAUKOS CORPORATION
Reel/Frame 070066/0322 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 29, 2025
From: HAFFNER, DAVID; CURRY, KEN; HEITZMANN, HAROLD; APPLEGATE, DAVID
To: DOSE MEDICAL CORPORATION
Reel/Frame 070047/0105 →
Continuity (9)
Continuation
13321144
Provisional Application
61264615
· Nov 25, 2009
Provisional Application
61264604
· Nov 25, 2009
Provisional Application
61264594
· Nov 25, 2009
Provisional Application
61220527
· Jun 25, 2009
Provisional Application
61179332
· May 18, 2009
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