Granted Patent B2

US 12,426,948 · App. 19/019,159 · Granted Sep 30, 2025

Inventors: Christopher V. Desimone (Rochester, MN); Barham K. Abu Dayyeh (Rochester, MN); Samuel J. Asirvatham (Rochester, MN)

Assignee: Mayo Foundation for Medical Education and Research

A61B18/1492A61B1/00082A61B1/00151A61B90/361A61N1/327A61N1/36007A61B2018/00065A61B2018/00083A61B2018/0016A61B2018/0022A61B2018/00238A61B2018/00261A61B2018/00285A61B2018/00494A61B2018/00577A61B2018/00613A61B2018/00839A61B2018/00982A61B2018/126A61B2018/1467A61B2018/1472A61B2090/3966A61B2218/002A61M2025/1004A61M25/1011A61M2025/1015A61M25/10181A61M2025/105A61M2025/1052A61M2025/1079

Abstract

Claims (33)

1. A method of treating diabetes in a patient, comprising:

advancing an electroporation device comprising one or more electrodes into a duodenum of the patient; and

delivering electroporation energy to mucosa of the duodenum using the one or more electrodes to treat diabetes, wherein the electroporation energy reshapes the mucosa of the duodenum.

2. The method of claim 1 , wherein the electroporation energy increases a level of a gut hormone important in appetite regulation.

3. The method of claim 1 , wherein the electroporation energy increases a level of a gut hormone important in insulin secretion.

4. The method of claim 1 , wherein the electroporation device comprises an inflatable member comprising the one or more electrodes.

5. The method of claim 4 , wherein the inflatable member is a balloon.

6. The method of claim 1 , wherein the electroporation device comprises a rolled-up member comprising the one or more electrodes.

7. The method of claim 1 , wherein the one or more electrodes comprise a plurality of spaced-apart electrodes.

8. The method of claim 1 , wherein the electroporation energy comprises pulse currents.

9. The method of claim 1 , wherein the one or more electrodes comprise bipolar electrodes.

10. The method of claim 1 , wherein delivering the electroporation energy comprises delivering irreversible electroporation energy.

11. The method of claim 1 further comprising transitioning the electroporation device from a first configuration to a second configuration, wherein transitioning the electroporation device to the second configuration stretches at least a portion of the duodenum.

12. The method of claim 11 , wherein the first configuration is a radially contracted configuration and the second configuration is a radially expanded configuration.

13. The method of claim 1 , wherein the electroporation device comprises a lumen configured to receive a guidewire therein.

14. A method of treating diabetes in a patient, comprising:

advancing an electroporation device comprising one or more electrodes into a duodenum of the patient; and

delivering electroporation energy to mucosa of the duodenum using the one or more electrodes to treat diabetes, wherein the electroporation energy resets diseased mucosa of the duodenum.

15. The method of claim 14 , wherein the electroporation device comprises an inflatable member comprising the one or more electrodes.

16. The method of claim 15 , wherein the inflatable member is a balloon.

17. The method of claim 14 , wherein the electroporation device comprises a rolled-up member comprising the one or more electrodes.

18. The method of claim 14 , wherein the one or more electrodes comprise a plurality of spaced-apart electrodes.

19. The method of claim 14 further comprising transitioning the electroporation device from a first configuration to a second configuration, wherein transitioning the electroporation device to the second configuration stretches at least a portion of the duodenum.

20. The method of claim 19 , wherein the first configuration is a radially contracted configuration and the second configuration is a radially expanded configuration.

21. The method of claim 14 , wherein delivering the electroporation energy comprises delivering irreversible electroporation energy.

22. A method of treating diabetes in a patient, comprising:

advancing an electroporation device comprising one or more electrodes into a duodenum of the patient;

transitioning the electroporation device from a first configuration to a second configuration, wherein transitioning the electroporation device to the second configuration stretches at least a portion of the duodenum; and

delivering electroporation energy to mucosa of the duodenum using the one or more electrodes to treat diabetes.

23. The method of claim 22 , wherein the electroporation device comprises an inflatable member comprising the one or more electrodes.

24. The method of claim 22 , wherein the electroporation device comprises a rolled-up member comprising the one or more electrodes.

25. The method of claim 22 , wherein the first configuration is a radially contracted configuration and the second configuration is a radially expanded configuration.

26. The method of claim 22 , wherein delivering the electroporation energy comprises delivering irreversible electroporation energy.

Continuity (4)

References Cited (400)