Granted Patent B2

US 12,496,408 · App. 19/028,127 · Granted Dec 16, 2025

Inventors: Carsten Mosebach (Frankfurt am Main, DE); Thomas Mark Kemp (Ashwell, GB)

Assignee: Sanofi-Aventis Deutschland GMBH

A61M5/3157A61M5/2033A61M5/31578A61M5/3158A61M5/3204A61M2205/581A61M2205/582

Abstract

Claims (14)

1 . A method of using an autoinjector, the method comprising:

axially moving a release member of the autoinjector relative to a case of the autoinjector along a longitudinal axis from (i) a first position in which a needle coupled to a syringe in the case is in a retracted position to (ii) a second position in which the needle is in an extended position;

moving a plunger of the autoinjector relative to a sleeve of the autoinjector between an initial position and a drug delivery position for delivering a medicament from the syringe, the sleeve comprising a body and a flexible arm movable relative to the body, the flexible arm comprising a proximal end coupled to the body and a distal end spaced from the body, wherein the distal end of the flexible arm is movable between a deflected position and a less-deflected position;

moving a first spring of the autoinjector to move the plunger in a distal direction relative to the sleeve, wherein the first spring has (a) a distal end in direct engagement with the plunger for biasing the plunger in the distal direction relative to the sleeve and (b) a proximal end in direct engagement with an interior surface of a proximal end of the sleeve, wherein a proximal end of the first spring is held in a fixed axial location as the plunger moves from the initial position to the drug delivery position;

moving a second spring of the autoinjector relative to the case between (I) a compressed state when the needle is in the extended position in which a distal tip of the needle is distal to a distal end of the autoinjector, and (II) an expanded state when the needle is in the retracted position in which the distal tip of the needle is proximal to the distal end of the autoinjector;

after the plunger moves into the drug delivery position, moving the flexible arm from the deflected position to the less-deflected position; and

generating an audible signal or a tactile signal to indicate completion of dispensing of the medicament when the flexible arm moves from the deflected position to the less-deflected position,

wherein the flexible arm extends at an angle with respect to a connection point of the body of the sleeve when the flexible arm is in the less-deflected position.

2 . The method of claim 1 , wherein the medicament comprises a glucagon-like peptide-1 (GLP-1) or an analogue or derivative thereof.

3 . The method of claim 1 , comprising generating the audible signal or the tactile signal when the sleeve impacts a proximal end of a cylindrical component of the autoinjector.

4 . The method of claim 1 , wherein axially moving the release member comprises depressing the release member.

5 . The method of claim 1 , wherein the sleeve is disposed around a proximal end of the plunger when the plunger is in the initial position.

6 . The method of claim 1 , wherein the release member moves telescopically relative to an axial end of the autoinjector.

7 . The method of claim 1 , wherein the flexible arm moves radially relative to a longitudinal axis of the autoinjector between the deflected position and the less-deflected position.

Assignments (1)

Priority Claims (1)

Continuity (4)

References Cited (205)

Cited By (1)

US 12,649,033