Fused imidazole derivative, preparation method therefor, and medical use thereof
Disclosed are fused imidazole derivatives, preparation methods therefor and medical uses thereof. Specifically, the present disclosure relates to a fused imidazole derivative as shown in general formula (IM), a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of same as a therapeutic agent, in particular the use thereof as a GLP-1 receptor agonist, and the use thereof in the preparation of drugs for the treatment and/or prevention of diabetes.
1 . A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2 . The compound of claim 1 , wherein the compound is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
3 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
4 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
5 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
6 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
7 . A compound, which is:
or a pharmaceutically acceptable salt thereof.
8 . The compound of claim 7 , which is:
9 . A compound, which is:
or a pharmaceutically acceptable salt thereof.
10 . The compound of claim 9 , which is:
11 . A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, diluents or excipients.
12 . A pharmaceutical composition comprising the compound of claim 2 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, diluents or excipients.
13 . A pharmaceutical composition comprising the compound of claim 3 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, diluents or excipients.
14 . A pharmaceutical composition comprising the compound of claim 4 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, diluents or excipients.
15 . A pharmaceutical composition comprising the compound of claim 5 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, diluents or excipients.
16 . A pharmaceutical composition comprising the compound of claim 6 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, diluents or excipients.
17 . A pharmaceutical composition comprising the compound of claim 7 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, diluents or excipients.
18 . A pharmaceutical composition comprising the compound of claim 8 , and one or more pharmaceutically acceptable carriers, diluents or excipients.
19 . A pharmaceutical composition comprising the compound of claim 9 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, diluents or excipients.
20 . A pharmaceutical composition comprising the compound of claim 10 , and one or more pharmaceutically acceptable carriers, diluents or excipients.