Granted Patent
B2
US 12,617,775 · App. 19/299,605 · Granted May 5, 2026
Processes of making CSF-1R inhibitors and methods of use thereof
Inventors:
Elena Kostik (Waltham, MA); Ann Gelormini (Waltham, MA); Michael D. Kaufman (Waltham, MA)
Assignee:
Deciphera Pharmaceuticals, LLC
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Abstract
The present disclosure relates to processes of making a compound represented by Formula (I) and methods of use thereof.
Claims (17)
1 . A dihydrate form of the compound of Formula (II):
prepared by a process comprising:
reacting a compound of Formula (IX):
with a compound of Formula (XII):
in the presence of a first catalyst to produce a compound of Formula (IV):
reacting the compound of Formula (IV) with a compound represented by:
in the presence of a second catalyst, to produce a compound of Formula (III):
and
reacting the compound of Formula (III) with isopropylamine,
thereby preparing the compound of Formula (II).
2 . A pharmaceutical composition, comprising the dihydrate form of claim 1 and a pharmaceutically acceptable excipient.
3 . The dihydrate form of claim 1 , wherein the first catalyst is a palladium catalyst.
4 . The dihydrate form of claim 1 , wherein the first catalyst is selected from the group consisting of Pd(PPh 3 ) 4 , Pd(OAc) 2 /SPhos, Pd(dppf)Cl 2 , Pd(dppf)Cl 2 ·DCM, XPhos Pd G2, and Pd 2 (dba) 3 .
5 . The dihydrate form of claim 1 , wherein the first catalyst is Pd(PPh 3 ) 4 .
6 . The dihydrate form of claim 1 , wherein the second catalyst is a palladium catalyst.
7 . The dihydrate form of claim 1 , wherein the second catalyst is selected from the group consisting of Pd(PPh 3 ) 4 , Pd(OAc) 2 /SPhos, Pd(dppf)Cl 2 , Pd(dppf)Cl 2 ·DCM, XPhos Pd G2, and Pd 2 (dba) 3 .
8 . The dihydrate form of claim 1 , wherein the second catalyst is Pd(PPh 3 ) 4 .
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 3, 2025
From: KOSTIK, ELENA; GELORMINI, ANN; KAUFMAN, MICHAEL D.
To: DECIPHERA PHARMACEUTICALS, LLC
Reel/Frame 072462/0060 →
Continuity (3)
Continuation
PCTUS2025027041
· Apr 30, 2025
Provisional Application
63641022
· May 1, 2024
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