Granted Patent
B2
US 12,285,430 · App. 18/140,942 · Granted Apr 29, 2025
Methods of treating disorders using CSF1R inhibitors
Inventors:
Daniel L. Flynn (Waltham, MA); Bryan D. Smith (Waltham, MA); Rodrigo Ruiz Soto (Waltham, MA); Keisuke Kuida (Waltham, MA)
Assignee:
Deciphera Pharmaceuticals, LLC
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Abstract
Described herein are methods of treating cancers and other tumors related to the decreased proliferation, the depletion, or the repolarization of tumor-associated macrophages (TAMs) and treatment of associated disorders, including tenosynovial giant cell tumor (TGCT) and diffuse-type tenosynovial giant cell tumor (DTGCT).
Claims (20)
1. A method of treating a tenosynovial giant cell tumor in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound represented by:
wherein after 1 month or more of administration, the patient has: (i) an improved tumor response as measured by CT, MRI and/or RECIST; and/or (ii) an improved range of motion; and/or (iii) reduced macrophage infiltration in the affected joint and/or circulating chemokine/cytokines associated with inflammation as compared to the amounts before administration.
2. The method of claim 1 , wherein the tumor is benign.
3. The method of claim 1 , wherein the tenosynovial giant cell tumor is a diffuse-type tenosynovial giant cell tumor.
4. The method of claim 1 , wherein the therapeutically effective amount is about 2 mg to about 60 mg of the compound twice weekly.
5. The method of claim 1 , wherein the therapeutically effective amount is about 5 mg to about 30 mg of the compound twice weekly.
6. The method of claim 1 , comprising administering to the patient the compound twice weekly for about 3 months.
7. The method of claim 1 , comprising administering to the patient the compound twice weekly for about 6 months.
8. The method of claim 1 , comprising administering to the patient the compound twice weekly for about 1 year.
9. The method of claim 1 , comprising administering to the patient the compound twice weekly for about 2 years.
10. A method of treating a tenosynovial giant cell tumor in a patient in need thereof, comprising administering to the patient 30 mg of a compound represented by:
twice weekly, wherein after 1 month or more of administration, the patient has: (i) an improved tumor response as measured by CT, MRI and/or RECIST; and/or (ii) an improved range of motion; and/or (iii) reduced macrophage infiltration in the affected joint and/or circulating chemokine/cytokines associated with inflammation as compared to the amounts before administration.
11. The method of claim 10 , wherein the tumor is benign.
12. The method of claim 10 , wherein the tenosynovial giant cell tumor is a diffuse-type tenosynovial giant cell tumor.
13. The method of claim 10 , comprising administering to the patient the compound twice weekly for about 3 months.
14. The method of claim 10 , comprising administering to the patient the compound twice weekly for about 6 months.
15. The method of claim 10 , comprising administering to the patient the compound twice weekly for about 1 year.
16. The method of claim 10 , comprising administering to the patient the compound twice weekly for about 2 years.
17. A method of treating a tenosynovial giant cell tumor in a patient in need thereof, comprising administering to the patient 30 mg of a compound represented by:
18. A method of treating a tenosynovial giant cell tumor in a patient in need thereof, comprising daily administering to the patient 50 mg of a compound represented by:
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 16, 2024
From: FLYNN, DANIEL L.; SMITH, BRYAN D.; KUIDA, KEISUKE; SOTO, RODRIGO RUIZ
To: DECIPHERA PHARMACEUTICALS, LLC
Reel/Frame 067114/0566 →
Continuity (6)
Provisional Application
62933830
· Nov 11, 2019
Provisional Application
62926341
· Oct 25, 2019
Provisional Application
62786105
· Dec 28, 2018
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