Water-soluble, chlorhexidine-containing compositions and use thereof
The invention relates to water-soluble, chlorhexidine-containing compositions having a long shelf life. The compositions are in the form of powder, granules or tablets and consist substantially of (i) a salt of chlorhexidine with 2 moles of a sugar acid and a microbicidally active quaternary ammonium bromide, or of (ii) chlorhexidine, a sugar acid or sugar lactone, with at least 2 moles of sugar acid or sugar lactone being present per mole of chlorhexidine, and a microbicidally active quaternary ammonium bromide. Peferred compositions consist substantially of chlorhexidine digluconate and N-cetyl-N,N,N-trimethylammonium bromide (cetrimide) in a weight ratio of 1:1 to 1:10. The solid compositions are stable, with little or no p-chloroaniline splitting off during storage.
1. A chlorhexidine composition comprising:
chlorhexidine and Δ-gluconolactone, wherein the chlorhexidine and Δ-gluconolactone are present in a molar ratio of 1:2 to 1:2.2, and
a microbicidally active quaternary ammonium bromide comprising cetramide;
wherein said chlorhexidine composition is water soluble and in the form of a powder, granule or tablet.
2. The chlorhexidine composition of claim 1 in the form of a powder.
3. The chlorhexidine composition of claim 1 in granular form.
4. The chlorhexidine composition of claim 1 in the form of a tablet.
5. The chlorhexidine composition of claim 1 , wherein the microbicidally active quaternary ammonium bromide consists of cetramide.
6. The chlorhexidine composition of claim 1 , wherein the chlorhexidine and the cetrimide are in a weight ratio ranging from 1:2 to 1:20.
7. The chlorhexidine composition of claim 1 , wherein the chlorhexidine and the cetrimide are in a weight ratio ranging from 1:5 to 1:20.
8. A method for forming an aqueous or aqueous-organic solution comprising:
mixing the chlorhexidine composition of claim 1 with a liquid containing water to form an aqueous or an aqueous-organic solution.
9. The method of claim 8 , wherein the liquid further comprises up to 2% of an alcohol selected from the group consisting of n-propanol, isopropanol, and ethanol.
10. An aqueous or aqueous-organic solution produced by the method of claim 8 .
11. A method for disinfecting a surface comprising:
applying the solution of claim 10 to a surface.
12. A method for making a chlorhexidine composition comprising:
mixing chlorhexidine and Δ-gluconolactone, wherein the chlorhexidine and Δ-gluconolactone are present in a molar ratio of 1:2 to 1:2.2, and a microbicidally active quaternary ammonium bromide which comprises cetramide to form a mixture, and
optionally pistillating, granulating, or tableting said mixture to form a powder, granule or tablet.