Granted Patent
B2
US 6,855,830 · App. 10/197,227 · Granted Feb 15, 2005
Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
Assignee:
Genzyme Corporation
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Abstract
Disclosed is a novel enantiomeric synthesis cermamide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
Claims (8)
1. A compound represented by the following structural formula:
the enantiomer of the compound, a salt of the compound, or
a salt of the enantiomer, wherein:
R 4 is H 2 or O; and
R 6 is represented by the following structural formula:
wherein phenyl ring A is substituted or unsubstituted; or
when R 4 is H 2 , R 6 can further be —H.
2. The compound of claim 1 wherein phenyl ring A is unsubstituted.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 20, 2012
From: HIRTH, BRADFORD H.; SIEGEL, CRAIG
To: GENZYME CORPORATION
Reel/Frame 028813/0756 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 22, 2002
From: HIRTH, BRADFORD H.; SIEGEL, CRAIG
To: GENZYME CORPORATION
Reel/Frame 013405/0918 →
Continuity (2)
Provisional Application
6030581400
· Jul 16, 2001