IP Library Granted Patent US 6,885,960
Granted Patent B2
US 6,885,960 · App. 10/375,510 · Granted Apr 26, 2005

Methods and devices for performing impedance spectroscopy

Assignee: Zyomyx, Inc.
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Quick Facts
Patent No.
US 6,885,960
App. No.
10/375,510
Granted
Apr 26, 2005
Kind
B2
Abstract

A highly time resolved impedance spectroscopy that enhances the measurement of the dynamics of non-stationary systems with enhanced time resolution. The highly time resolved impedance spectroscopy includes an optimized, frequency rich a.c., or transient, voltage signal is used as the perturbation signal, non-stationary time to frequency transformation algorithms are used when processing the measured time signals of the voltage and current to determine impedance spectra which are localized in time; and the system-characterizing quantities are determined from the impedance spectra using equivalent circuit fitting in a time-resolution-optimized form. Methods and apparatus for processing impedance spectra data are also provided.

Claims (50)

1. A method of data processing, comprising:

receiving impedance spectra data from a plurality of measurement electrodes within a test matrix; and

displaying the impedance spectra data in a two-dimensional array of a display, wherein an element of the two-dimensional array relates to a relative position of a corresponding measurement electrode within the test matrix, and wherein the impedance spectra data is displayed using a color that indicates a value of the impedance spectra data of the corresponding measurement electrode within the test matrix.

2. The method as defined in claim 1 , wherein the impedance spectra data is a conductance.

3. A method as defined in claim 1 , wherein the impedance spectra data is a capacitance.

4. A method as defined in claim 1 , wherein different colors are used to indicate a data type.

5. A method as defined in claim 4 , wherein the data type is a conductance.

6. A method as defined in claim 4 , wherein the data type is a capacitance.

7. A method as defined in claim 1 , wherein the elements of the two-dimensional array comprise sub-elements.

8. A method as defined in claim 7 , wherein each sub-element indicates a different data type at a corresponding measurement electrode within the test matrix.

9. A method as defined in claim 8 , wherein the data type is a conductance.

10. A method as defined in claim 8 , wherein the data type is a capacitance.

11. A method as defined in claim 7 , wherein there are two sub-elements in an element of the two-dimensional array.

12. An apparatus that measures highly time resolved impedance spectra, comprising:

a processor that receives impedance spectra data from a plurality of measurement electrodes within a test matrix and produces output data for display; and

a display that shows the output data as a two-dimensional array representing a measured impedance spectra from the measuring electrodes in the test matrix, wherein an element of the two-dimensional array relates to a relative position of a corresponding measurement electrode within the test matrix, and wherein the impedance spectra data is displayed using a color that indicates a value of the impedance spectra data of the corresponding measurement electrode within the test matrix.

13. An apparatus as defined in claim 12 , wherein the impedance spectra data is a conductance.

14. An apparatus as defined in claim 12 , wherein the impedance spectra data is a capacitance.

15. An apparatus as defined in claim 12 , wherein different colors are used to indicate a data type.

16. An apparatus as defined in claim 15 , wherein the data type is a conductance.

17. An apparatus as defined in claim 16 , wherein the data type is a capacitance.

18. An apparatus as defined in claim 12 , wherein the elements of the two-dimensional array comprises sub-elements.

19. An apparatus as defined in claim 18 , wherein each sub-element indicates a data type at a corresponding measurement electrode within the test matrix.

20. An apparatus as defined in claim 19 , wherein the data type is a conductance.

21. An apparatus as defined in claim 19 , wherein the data type is a capacitance.

22. An apparatus as defined in claim 18 , wherein the display element includes two sub-elements.

23. A method of data processing, comprising:

receiving impedance spectra data from a plurality of measurement electrodes within a test matrix, wherein the test matrix comprises six channels with six measurement electrodes within each channel; and

displaying the impedance spectra data in a two-dimensional array of a display, wherein an element of the two-dimensional array relates to a relative position of a corresponding measurement electrode within the test matrix, and wherein the impedance spectra data is displayed using a color that indicates a value of the impedance spectra data of the corresponding measurement electrode within the test matrix.

24. The method as defined in claim 23 , wherein displaying the impedance spectra data in a two dimensional array comprises displaying the impedance data in a six by six array.

25. The method as defined in claim 23 , wherein the impedance spectra data is obtained from measurements on ion channels in supported lipid membranes.

26. A method of data processing, comprising:

receiving impedance spectra data from a plurality of measurement electrodes within a test matrix, wherein the impedance spectra data is obtained from measurements on ion channels in supported lipid membranes; and

displaying the impedance spectra data in a two-dimensional array of a display, wherein an element of the two-dimensional array relates to a relative position of a corresponding measurement electrode within the test matrix, and wherein the impedance spectra data is displayed using a color that indicates a value of the impedance spectra data of the corresponding measurement electrode within the test matrix.

27. A method of data processing, comprising:

receiving impedance spectra data from a plurality of measurement electrodes within a test matrix; and

displaying the impedance spectra data in a two-dimensional array of a display, wherein an element of the two-dimensional array relates to a relative position of a corresponding measurement electrode within the test matrix, wherein the elements of the two-dimensional array each comprise two sub-elements that are triangles that together form a square, and wherein the impedance spectra data is displayed using a color that indicates a value of the impedance spectra data of the corresponding measurement electrode within the test matrix.

28. The method as defined in claim 27 , wherein each sub-element indicates a different data type at a corresponding measurement electrode within the test matrix.

29. An apparatus that measures highly time resolved impedance spectra, comprising:

a processor that receives impedance spectra data from a plurality of measurement electrodes within a test matrix and produces output data for display, wherein the test matrix comprises six channels with six measurement electrodes within each channel; and

a display that shows the output data as a two-dimensional array representing a measured impedance spectra from the measuring electrodes in the test matrix, wherein an element of the two-dimensional array relates to a relative position of a corresponding measurement electrode within the test matrix, and wherein the impedance spectra data is displayed using a color that indicates a value of the impedance spectra data of the corresponding measurement electrode within the test matrix.

30. An apparatus as defined in claim 29 , wherein displaying the impedance spectra data in a two dimensional array comprises displaying the impedance data in a six by six array.

31. An apparatus that measures highly time resolved impedance spectra, comprising:

a processor that receives impedance spectra data from a plurality of measurement electrodes within a test matrix and produces output data for display, wherein the impedance spectra data is obtained from measurements on ion channels in supported lipid membranes; and

a display that shows the output data as a two-dimensional array representing a measured impedance spectra from the measuring electrodes in the test matrix, wherein an element of the two-dimensional array relates to a relative position of a corresponding measurement electrode within the test matrix, and wherein the impedance spectra data is displayed using a color that indicates a value of the impedance spectra data of the corresponding measurement electrode within the test matrix.

32. An apparatus that measures highly time resolved impedance spectra, comprising:

a processor that receives impedance spectra data from a plurality of measurement electrodes within a test matrix and produces output data for display; and

a display that shows the output data as a two-dimensional array representing a measured impedance spectra from the measuring electrodes in the test matrix, wherein an element of the two-dimensional array relates to a relative position of a corresponding measurement electrode within the test matrix, wherein the elements of the two-dimensional array each comprise two sub-elements that are triangles that together form a square, and wherein the impedance spectra data is displayed using a color that indicates a value of the impedance spectra data of the corresponding measurement electrode within the test matrix.

33. The apparatus as defined in claim 32 , wherein each sub-element indicates a data type at a corresponding measurement electrode within the test matrix.

34. The apparatus as defined in claim 32 , wherein the impedance spectra data is obtained from measurements on ion channels in supported lipid membranes.

Assignments (2)
SECURITY AGREEMENT Recorded May 6, 2011
From: ZYOMYX, INC.
To: BILL & MELINDA GATES FOUNDATION
Reel/Frame 026240/0824 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 5, 2003
From: WAGNER, PETER; WIEGAND, GERALD
To: ZYOMYX, INC.
Reel/Frame 014656/0740 →
Continuity (2)
Provisional Application 6035989300 · Feb 25, 2002
Related Publication 20040073390A1 · Apr 15, 2004