Saccharide derivatives especially useful in wound dressings
Sequestrants and inhibitors of protease are applied to the wound site through the use of wound dressing based carrier systems to which they may be optionally ionically or covalently bound for the purpose of the initiation or enhancement of healing associated with chronic non-healing wounds.
1. A saccharide derivative wherein:
a saccharide having anhydroglucose units is linked to “A” at the 2,3 or 6 position of the anhydroglucose units; and
“A” is:
methyl chloroformate,
pentafluoroethylketone,
dihydroxylketone,
levulinate,
alkyl ketone,
2,3 dialdehyde anhydroglucose,
glucose-6-citrate,
2,3 dialdehydo-glucose-6-citrate,
Leu,
Ile,
Val,
Me,
Val-Pro,
Pro-Val,
Ala-Pro-Val,
Val-Pro-Ala,
a tetrapeptide sequence wherein any of the following amino acids are the amino terminal residue of Ala-Pro-Val or Val-Pro-Ala; Lys, Arg, Trp, Phe, Gln, His, Tyr, and are linked through the amino- or COOH- termini of the peptide to the saccharide;
with the proviso that when A is an amino acid or peptide A may also be derivatized at its unbound amino- or COOH-terminus as an acid, carboxamide, alcohol, ester, ketone, aldehyde, ketomethylester, methyl chioroformate, pentafluoroethylketone or p-nitroanilide.
2. A saccharide derivative, wherein:
a saccharide is linked to a di-, tri-, or tetrapeptide “B”; and,
“B” is:
Leu,
Ile,
Val,
Nle;
Val-Pro,
Pro-Val,
Ala-Pro-Val
Val-Pro-Ala, or
a tetrapeptide sequence having an amino terminal residue selected from the group consisting of Ala-Pro-Val or Val-Pro-Ala; Lys, Arg, Trp, Phe, Gln, His, Tyr.
3. The saccharide derivative of claim 2 , wherein “B” is a peptide linked through an amino- or COOH- termini of the peptide to the saccharide through a salt bridge or embedded in saccharide formulation.
4. The saccharide derivative of claim 1 , wherein “A” is glucose-6-citrate.
5. The saccharide derivative of claim 1 , wherein “A” is levulinate.
6. The saccharide derivative of claim 1 , wherein the saccharide comprises a C 1 -C 8 alkyl ether, carboxylate, citrate, alkoxysuccinate, phosphate, sulfonate, alkyl amine, or thioalkyl.