Methods and devices for providing prolonged drug therapy
Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.
1. A method for treating Attention-Deficit Disorder or Attention-Deficit Hyperactivity Disorder in a patient, wherein the method comprises administering a pharmaceutically acceptable composition comprising methylphenidate and a pharmaceutically acceptable carrier to said patient in a manner that achieves a substantially ascending methylphenidate plasma drug concentration over a time period of about 8 hours following said administration.
2. A method for treating Attention-Deficit Disorder or Attention-Deficit Hyperactivity Disorder in a patient, wherein the method comprises administering a pharmaceutically acceptable composition comprising methylphenidate and a pharmaceutically acceptable carrier to said patient in a manner that achieves a substantially ascending methylphenidate plasma drug concentration over a time period of about 9.5 hours following said administration.
3. A method of claim 1 wherein said composition comprises about 14 mg of methylphenidate.
4. A method of claim 1 wherein said composition comprises about 18 mg of methylphenidate.
5. A method of claim 1 wherein said composition comprises about 36 mg of methylphenidate.
6. A method of claim 1 wherein said composition comprises about 54 mg of methylphenidate.
7. A method of claim 2 wherein said composition comprises about 14 mg of methylphenidate.
8. A method of claim 2 wherein said composition comprises about 18 mg of methylphenidate.
9. A method of claim 2 wherein said composition comprises about 36 mg of methylphenidate.
10. A method of claim 2 wherein said composition comprises about 54 mg of methylphenidate.