IP Library › Granted Patent US 6,953,861
Granted Patent B2
US 6,953,861 · App. 10/805,624 · Granted Oct 11, 2005

Method of re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide

Assignees: The Trustees of Columbia University in the City of New York; The Rockefeller University
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Quick Facts
Patent No.
US 6,953,861
App. No.
10/805,624
Granted
Oct 11, 2005
Kind
B2
Abstract

The present invention relates to pyrrolidine compounds of the general structure: where n is an integer 1-6 and R is hydrogen or a C 1 to C 6 straight chain or branched alkyl group, and wherein when n=1, R=CH 3 or H, useful for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond on the cell wall peptide precursors of the bacteria.

Claims (8)

1. A compound having the structure:

wherein n is an integer from 1 to 6 inclusive and R is hydrogen or a C 1 to C 6 straight chain or branched alkyl group, and wherein when n=1, R=CH 3 or H.

2. The compound of claim 1 , wherein n=1 and R=CH 3 .

3. The compound of claim 1 , wherein n=1 and R=H.

4. The compound of claim 1 , wherein n=2 and R=H.

5. The compound of claim 1 wherein n=3 and R=H.

6. The compound of claim 1 , wherein n=5 and R=H.

7. The compound of claim 1 , wherein n=6 and R=H.

Assignments (1)
EXECUTIVE ORDER 9424, CONFIRMATORY LICENSE Recorded Dec 18, 2008
From: COLUMBIA UNIVERSITY NEW YORK MORNINGSIDE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 022003/0546 →
Continuity (2)
Continuation 0993874600 · Aug 23, 2001
Related Publication 20040180814A1 · Sep 16, 2004