Nasal spray for treating streptococcal infections
View Patent ↗A nasal spray for treating a streptococcal infection is disclosed. The spray comprises an effective amount of a lysin enzyme genetically coded for by a C 1 bacteriophage capable of infecting a group C Streptococcal bacteria, and a nasal spray carrier for delivering said lysin enzyme to a mouth, throat, or nasal passage.
1. A nasal spray for treating a streptococcal infection, comprising:
(i) an effective amount of a lysin enzyme genetically coded for by a C1 bacteriophage capable of infecting a group C Streptococcus bacteria, said lysin enzyme characterized by the ability to specifically destroy the cell wall of a Group A Streptococcili;
ii) a nasal spray for delivering said lysing enzyme to a or nasal passage; and
iii) a nasal sprayer for delivering said nasal spray.
2. The nasal spray according to claim 1 , further comprising a buffer that maintains pH of the nasal spray at a range between about 4.0 and 9.0.
3. The nasal spray according to claim 2 , wherein said buffer maintains the pH of the nasal spray at range between 5.5 and 7.5.
4. The nasal spray according to claim 2 , wherein said buffer comprises a reducing agent.
5. The nasal spray according to claim 4 , wherein said reducing agent is dithiothreitol.
6. The nasal spray according to claim 2 , wherein said buffer comprises a metal chelating agent.
7. The nasal spray according to 6 , wherein said metal chelating agent is ethyldiaminetetraacetic disodium salt.
8. The nasal spray according to claim 2 , wherein said buffer is a citrate-phosphate buffer.
9. The nasal spray according to claim 1 , wherein further comprising a bactericidal or bacteriostatic agent as a preservative.
10. The nasal spray according to claim 1 , wherein said lysin enzyme is lyophilized.
11. The nasal spray according to claim 1 , wherein said carrier further comprises a sweetener.
12. The nasal spray according to claim 1 , wherein said carrier is suitable for delivering said lysin enzyme to the nasal passage.