Molecular database for antibody characterization
The invention relates to a cumulative, evolving molecular database of monospecific probes and their characteristics. In particular, the invention relates to a computer repository of histograms based upon quantitative flow cytometry. The invention further relates to a system containing a database of monospecific probe properties, the database connected to users through a network to allow users to enter selection criteria and retrieve monospecific probe properties. The invention further relates to a data set useful to refine existing analytic algorithms. The refinement of these algorithms enables computer searches for relationships between known and unknown monospecific probes. Thus, the invention also provides for searching in the database to identify relationships between monospecific probes, groups of probes, and their targets.
1. A system allowing users to obtain information on monospecific probes in an online directory comprising:
a web site containing a database of monospecific probe properties, wherein said database comprises monospecific probe properties identified by flow cytometry, and wherein the information in the database comprises monospecific probe histograms, and connected to users through a computer network to allow users to enter selection criteria for retrieving monospecific probe properties;
wherein the web site produces a list of matching information on monospecific probes matching the selection criteria and displays the matching information on monospecific probes on the list in an order determined by each matching probe's similarity to the selection criteria.
2. The system of claim 1 wherein the histograms have been subjected to kernel smoothing or kernel density estimation.
3. The system of claim 1 wherein the order is determined by a technique selected from the group consisting of a feature space model, relevance feedback, set training, and performance measurement.
4. A method of providing information concerning monospecific probes to users through a web site, comprising the steps of:
receiving information relating a monospecific probe from a user;
comparing the information to a monospecific probe information database, wherein said database comprises monospecific probe properties identified by flow cytometry, and wherein the information in the database comprises monospecific probe histograms;
compiling a list of matching monospecific probe information matching the information relating to a monospecific probe received from a user; and
displaying the matching monospecific probe information in an order determined by similarity of the information relating to a monospecific probe from a user to the monospecific probe information in the database.
5. The method of claim 4 further including the steps of receiving a monospecific probe from a user; and generating a histogram for the received monospecific probe by the same flow cytometer as the histograms generated for the monospecific probe whose information is contained in the information database.
6. The method of claim 5 wherein the histogram of the monospecific probe received from a user and the histograms of the monospecific probes contained in the database are subjected to kernel smoothing or kernel density estimation before comparison.
7. A directory computer containing a database, wherein said database comprises monospecific probe properties identified by flow cytometry, and wherein the information in the database comprises monospecific probe histograms, that permits users to obtain a list of monospecific probes matching selection criteria provided by the users through a web site hosted on the directory computer, wherein said directory computer displays matching monospecific probes matching the selection criteria in an order determined by each matching monospecific probe's similarity to the selection criteria.
8. The directory of claim 7 wherein the selection criteria is similarity of histograms.
9. The directory of claim 7 wherein the histograms have been subjected to kernel smoothing or kernel density estimation.
10. The directory of claim 7 wherein the order is determined by a technique selected from the group consisting of a feature space model, relevance feedback, set training, and performance measurement.
11. A computer readable medium having stored thereon computer-executable instructions for:
receiving selection criteria relating to information on a monospecific probe from a user;
compiling a list of matching monospecific probes matching the selection criteria from a database of monospecific probe information, wherein said database comprises monospecific probe properties identified by flow cytometry, and wherein the information in the database comprises monospecific probe histograms; and
displaying the matching monospecific probe information in an order determined by each matching mono specific probe's similarity to the selection criteria.
12. The computer readable medium of claim 11 wherein the histograms have been subjected to kernel smoothing or kernel density estimation.
13. The computer readable medium of claim 11 wherein the order is determined by a technique selected from the group consisting of a vector space model, relevance feedback, training set, and performance measurement.