Receptor specific transepithelial transport of therapeutics
View Patent ↗The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
1. A pharmaceutical preparation for suppressing an immune response comprising:
(i) a conjugate of an antigen and an FcRn binding partner other than whole IgG, wherein the antigen is selected from the group consisting of:
an antigen that is characteristic of an autoimmune disease, and
an antigen that is characteristic of an allergen; and
(ii) a pharmaceutically acceptable carrier, wherein the preparation is formulated as a unit dosage containing an effective amount of the conjugate for suppressing the immune response of a mammal when administered to an apical surface of an epithelial barrier of the mammal, wherein the unit dosage is an oral formulation.
2. The pharmaceutical preparation of claim 1 , wherein the oral formulation is a solid oral formulation, an elixir or a syrup.
3. The pharmaceutical preparation of claim 1 , wherein the FcRn binding partner is an Fc fragment of IgG.
4. The pharmaceutical preparation of claim 1 , wherein the antigen is covalently coupled to the FcRn binding partner.
5. A pharmaceutical preparation for suppressing an immune response comprising:
an aerosol formulation of
(i) a conjugate of an antigen and an FcRn binding partner other than whole IgG, wherein the antigen is selected from the group consisting of:
an antigen that is characteristic of an autoimmune disease, and
an antigen that is characteristic of an allergen; and
(ii) a pharmaceutically acceptable carrier, wherein the preparation is formulated as a unit dosage containing an effective amount of the conjugate for suppressing the immune response of a mammal when administered to an apical surface of an epithelial barrier of the mammal.
6. The pharmaceutical preparation of claim 5 , wherein the aerosol formulation comprises a propellant.
7. The pharmaceutical preparation of claim 5 , wherein the FcRn binding partner is an Fc fragment of IgG.
8. The pharmaceutical preparation of claim 5 , wherein the antigen is covalently coupled to the FcRn binding partner.
9. The pharmaceutical preparation of claim 5 , wherein the preparation is contained in an inhaler or insufflator comprising a powder mix comprising the conjugate and a powder base.
10. The pharmaceutical preparation of claim 9 , wherein the powder mix is contained in a capsule or cartridge.
11. The pharmaceutical preparation of claim 9 , wherein the powder base is lactose.
12. The pharmaceutical preparation of claim 9 , wherein the powder base is starch.