IP Library Granted Patent US 7,070,786
Granted Patent B2
US 7,070,786 · App. 10/456,092 · Granted Jul 4, 2006

RSV proteins, antibodies, compositions, methods and uses

Assignee: Centocor, Inc.
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Quick Facts
Patent No.
US 7,070,786
App. No.
10/456,092
Granted
Jul 4, 2006
Kind
B2
Abstract

The present invention relates to at least one novel RSV proteins, antibodies, including isolated nucleic acids that encode at least one RSV protein or antibody, RSV vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

Claims (6)

1. At least one isolated mammalian RSV antibody, comprising at least one heavy chain variable region of SEQ. ID. No. 7 and at least one light chain variable region of SEQ. ID. No. 10.

2. An RSV antibody according to claim 1 wherein said antibody binds RSV with an affinity of at least one selected from at least 10 −9 M, at least 10 −10 M, at least 10 −11 M, or at least 10 −12 M.

3. An RSV antibody according to claim 1 , wherein said antibody substantially modulates at least one activity of at least one RSV polypeptide.

4. A composition comprising at least one isolated mammalian RSV antibody according to claim 1 having at least one human CDR, wherein said antibody specifically binds at least one epitope comprising at least 1–3, to the entire amino acid sequence of SEQ ID NO: 9, and at least one pharmaceutically acceptable carrier or diluent.

5. A composition according to claim 4 , further comprising at least one at least one compound or polypeptide selected from at least one of a detectable label or reporter, a TNF antagonist, an anti-infective drug, a cardiovascular (CV) system drug, a central nervous system (CNS) drug, an autonomic nervous system (ANS) drug, a respiratory tract drug, a gastrointestinal (GI) tract drug, a hormonal drug, a drug for fluid or electrolyte balance, a hematologic drug, an antineoplastic, an immunomodulation drug, an opthalmic, otic or nasal drug, a topical drug, a nutritional drug, a cytokine, or a cytokine antagonist.

6. A method for producing an isolated mammalian RSV antibody of claim 1 , comprising providing a host cell or transgenic animal or transgenic plant or plant cell capable of expressing in recoverable amounts said antibody.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 6, 2003
From: SCALLON, BERNARD
To: CENTOCOR, INC.
Reel/Frame 014160/0298 →
Continuity (1)
Related Publication 20040248082A1 · Dec 9, 2004